GMS6121– Complete exam material with
correct precise answers 2025/2026
Updated Version
Introduction:
This document contains complete exam material for GMS6121
Exam 2, including detailed questions and precise answers
covering major virology topics. It reviews HIV, HPV,
herpesviruses, mononegavirales, reoviruses, retroviruses,
poxviruses, and rotaviruses, including genome organization,
replication strategies, pathogenesis, immune evasion, and viral
protein functions. The material is structured in a Q&A format,
making it ideal for active recall and exam preparation. It
appears to comprehensively cover all key lecture concepts
relevant to the second exam.
Exam Questions and Answers:
origins of HIV? ---Correct Precise Answer---likely chimp got
infected with 2 SIV's from 2 sep monkeys that resulted in
rearrangement in africa
HIV transmission ---Correct Precise Answer---unprotected sex
sharing needles
,mother-fetus
infected blood prods
what cells do HIV infect? ---Correct Precise Answer---
macrophages and DC's (innate immune system)
CD4 T cells
3 stages of HIV infection ---Correct Precise Answer---acute
infection, clinical latency, AIDS
Why is HIV difficult to treat? ---Correct Precise Answer---1.
high rate of viral replication
2. low fidelity of RT (error-prone)
3. ability to recombine
papilloma genome organization? ---Correct Precise Answer---
dsDNA circular
naked (not enveloped)
icosahedral capsid
8-10 genes
, how many HPV strains are "high-risk" and which two cause
majority of cervical cancer ---Correct Precise Answer---15.
HPV-16 and 18
where do HPV strains show tissue specificity? ---Correct
Precise Answer---skin or mucosa
what two HPV strains are associated with genital warts? ---
Correct Precise Answer---HPV-6 and 11
papillo life cycle ---Correct Precise Answer---bottom layer-
basal cells: early gene expression and plasmid DNA rep (50
copies/cell)
keratinocytes- vegetative replication (1000 copies/cell) & late
gene expression
papilloma function of E7? ---Correct Precise Answer---
activates cell cycle progression by binding to Rb. (Rb originally
binds to E2F which causes cell cycle arrest)
papilloma function of E6? ---Correct Precise Answer---blocks
apoptosis by inducing p53 degradation. (E7 causes activation
of p53)
correct precise answers 2025/2026
Updated Version
Introduction:
This document contains complete exam material for GMS6121
Exam 2, including detailed questions and precise answers
covering major virology topics. It reviews HIV, HPV,
herpesviruses, mononegavirales, reoviruses, retroviruses,
poxviruses, and rotaviruses, including genome organization,
replication strategies, pathogenesis, immune evasion, and viral
protein functions. The material is structured in a Q&A format,
making it ideal for active recall and exam preparation. It
appears to comprehensively cover all key lecture concepts
relevant to the second exam.
Exam Questions and Answers:
origins of HIV? ---Correct Precise Answer---likely chimp got
infected with 2 SIV's from 2 sep monkeys that resulted in
rearrangement in africa
HIV transmission ---Correct Precise Answer---unprotected sex
sharing needles
,mother-fetus
infected blood prods
what cells do HIV infect? ---Correct Precise Answer---
macrophages and DC's (innate immune system)
CD4 T cells
3 stages of HIV infection ---Correct Precise Answer---acute
infection, clinical latency, AIDS
Why is HIV difficult to treat? ---Correct Precise Answer---1.
high rate of viral replication
2. low fidelity of RT (error-prone)
3. ability to recombine
papilloma genome organization? ---Correct Precise Answer---
dsDNA circular
naked (not enveloped)
icosahedral capsid
8-10 genes
, how many HPV strains are "high-risk" and which two cause
majority of cervical cancer ---Correct Precise Answer---15.
HPV-16 and 18
where do HPV strains show tissue specificity? ---Correct
Precise Answer---skin or mucosa
what two HPV strains are associated with genital warts? ---
Correct Precise Answer---HPV-6 and 11
papillo life cycle ---Correct Precise Answer---bottom layer-
basal cells: early gene expression and plasmid DNA rep (50
copies/cell)
keratinocytes- vegetative replication (1000 copies/cell) & late
gene expression
papilloma function of E7? ---Correct Precise Answer---
activates cell cycle progression by binding to Rb. (Rb originally
binds to E2F which causes cell cycle arrest)
papilloma function of E6? ---Correct Precise Answer---blocks
apoptosis by inducing p53 degradation. (E7 causes activation
of p53)
