CMN 552 Exam 1
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What two neurotransmitters are most implicated in the norepinephrine and serotonin
pathophysiology of mood disorders?
How are dopamine levels affected in depression and Dopamine activity may be reduced in depression and increased in mania
mania?
How does depression affect sleep neurophysiology? Loss of deep (slow-wave) sleep
Increase in nocturnal arousal.
The latter is reflected by four types of disturbance: (1) an increase in nocturnal
awakenings, (2) a reduction in total sleep time, (3) increased phasic rapid eye
movement (REM) sleep, and (4) increased core body temperature. T
What is the most common abnormality found in structural Increased frequency of abnormal hyperintensities in subcortical regions, such as
and functional brain imaging in depressive disorders? periventricular regions, the basal ganglia, and the thalamus
What cognitive distortions are commonly seen in (1) views about the self —a negative self-precept, (2) about the environment—a
depressed patients? tendency to experience the world as hostile and demanding, and (3) about the
future—the expectation of suffering and failure
What is learned helplessness? the hopelessness and passive resignation an animal or human learns when unable
to avoid repeated aversive events
What "specifiers" are used to describe patients with Table 8.1-7
various mood disorders?
,What factors are associated with a poor prognosis for MDD: The percentage of patients recovering after repeated hospitalization
patients with mood disorders? decreases with passing time. Generally, as a patient experiences more and more
depressive episodes, the time between the episodes decreases, and the severity
of each episode increases.
Bipolar I: Have a poorer prognosis than do patients with major depressive
disorder. About 40 to 50 percent of patients with bipolar I disorder may have a
second manic episode within 2 years of the first episode. poor occupational
status, alcohol dependence, psychotic features, depressive features, interepisode
depressive features, and male gender were all factors that contributed a poor
prognosis. Short duration of manic episodes, advanced age of onset, few suicidal
thoughts, and few coexisting psychiatric or medical problems predict a better
outcome.
Bipolar II: The course and prognosis of bipolar II disorder indicate that the
diagnosis is stable because there is a high likelihood that patients with bipolar II
disorder will have the same diagnosis up to 5 years later. Bipolar II disorder is a
chronic disease that warrants long-term treatment strategies.
What is endogenous depression? depression with no apparent cause
What characteristics would the clinician see if a patient Catatonic features
presented with atypical features in a depressed patient? Postpartum onset
Rapid cycling
Seasonal features
Significant weight gain
Hypersomnia
Leaden paralysis
, What diagnostic criteria are required for a patient to *Five (or more) of the following symptoms have been present during the same 2-
receive a diagnosis of Major Depressive Disorder? week period and represent a change from previous functioning; at least one of
the symptoms is either (1) depressed mood or (2) loss of interest or pleasure.
Depressed most of the day, nearly every day as indicated by subjective report
(e.g., feels sad, empty, hopeless) or observation made by others (e.g., appears
tearful)
Markedly diminished interest or pleasure in all, or almost all, activities most of the
day, nearly every day (as indicated by subjective account or observation)
Significant weight loss when not dieting or weight gain (e.g., change of more than
5% of body weight in a month), or decrease or increase in appetite nearly every
day
Insomnia or hypersomnia nearly every day
Psychomotor agitation or retardation nearly every day (observable by others, not
merely subjective feelings of restlessness or being slowed down)
Fatigue or loss of energy nearly every day
Feelings of worthlessness or excessive or inappropriate guilt (which may be
delusional) nearly every day (not merely self-reproach or guilt about being sick).
Diminished ability to think or concentrate, or indecisiveness, nearly every day
(either by subjective account or as observed by others)
Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation
without a specific plan, or a suicide attempt or a specific plan for committing
suicide
The symptoms cause clinically significant distress or impairment in social,
occupational, or other important areas of functioning.
The episode is not attributable to the physiological effects of a substance or to
another medical condition.
The occurrence of the major depressive episode is not better explained by
schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional
disorder, or other specified and unspecified schizophrenia spectrum and other
psychotic disorders.
There has never been a manic episode or a hypomanic episode.
What are some common sleep disturbances experienced Insomnia, hypersomnia.
by patients with MDD?