Estrogen in COcs stabilizes the endometrium, contributes
to inhibition of ovulation through suppressio nof FSH.
However, mostly potentiates the action of progestin which
has the most contraceptive effect.
People who take ospemifine for tx of dyspareunia related
to vulvovaginal atrophy should be advised that they:
a. Will need to take progesterone in addition to prevent
endometrial hyperplasia
b. May also need vaginal estrogen to enhance the meds
effect
, c. May experience vasosmotor sx as a side effect of this
medication
d. Should take this med 2-3 hr before having sexual
intercourse - ANSWERc. May experience vasosmotor sx
as a side effect of this medication
Ospemifine is a SERM taken to tx severe dyspareunia r/t
to atrophy. Hot flashes are a common side effect. Do not
use in combination w/ estrogen.
Patient's contraceptive patch falls off, but was easily
reapplied. It was fully attached yesterday before having
sex. Appropriate advise includes: