TESTBANKFORMODERNBLOODBANKING&
TRANSFUSIONPRACTICES7THEDITIONBY
DENISEMHARMENING
9780803668881CHAPTER1-29COMPLETE
GUIDE
,https://www.stuvia.com/
Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
wq wq wq wq wq wq wq wq wq wq
Multiple Choicewq
Identify the choice that best completes the statement or answers the question.
wq wq wq wq wq wq wq wq wq wq wq
1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
wq wq wq wq wq wq wq wq wq wq wq wq wq
a. Pentose phosphate shunt c. Glycolysis wq wq
b. Luebering-Rapoport shunt d. Methemoglobin reductase wq w q wq
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed. The
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most a ccurate
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
?
a. The unit of blood should be discarded immediately. wq wq wq wq wq wq wq
b. The unit of blood can be returned to inventory. wq wq wq wq wq wq wq wq
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
d. The unit of blood must be transfused with 24 hours.wq wq wq wq wq wq wq wq wq
3. What is the average diameter of a platelet?
wq wq wq wq wq wq wq
a. 5 to 10 µm wq wq wq c. 1 to 2 µm wq wq wq
b. 2 to 4 µm wq wq wq d. 4 to 6 µm wq wq wq
4. In the normal hemoglobin-
wq wq wq
oxygen dissociation curve, what percentage of oxygen is releasedKto the tissuesKwhen PO2 averages 4
wq wq wq wq wq wq wq wq wq wq wq w q wq
0 mm Hg? w q wq wq
a. 75% c. 100%
b. 25% d. 50% w q w q
5. What factors are known to influence platelet metabolism and function?
wq wq wq wq wq wq wq wq wq
a. Storage temperature c. Platelet count wq wq
b. Initial pH d. All of theKabove wq w q wq wq
6. Which of the following red blood cellKmorphologies mayKbeKpresent on the peripheral blood smear as a re su
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
lt of loss of RBC membrane?
wq wq wq wq wq
a. Spherocytes c. Burr cells wq
b. Target cells d. Schistocytes wq w q
7. What does the term autologous transfusionKrefer to?
wq wq wq wq wq wq
a. A parent donating blood for his orKher child
wq wq wq wq wq wq wq
b. An individualKdonating bloodKfor a friend wq wq wq wq
c. An individualKdonating blood forKa relative wq wq wq wq
d. AnKindividual donating bloodKfor his or her own transfusion wq wq wq wq wq wq wq
8. What is theKprimary functionKof hemoglobin?
wq wq wq wq
a. Iron metabolism c. Oxygen transport
wq wq
b. Porphyrin synthesis d. Signal transduction wq w q wq
9. All of the followingKareas of red blood cell biology are crucial for normal erythrocyte survival except:
wq wq wq wq wq wq wq wq wq wq wq wq wq wq w q
a. Cellular metabolism. c. Site of the ABO antigen attachment.
wq wq wq wq wq wq
b. RBC membrane. d. Hemoglobin structure.
wq w q wq
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
wq wq wq wq w q wq w q wq w q w q
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w q w q wq
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wq 10. What is the correct biochemical composition of the RBC membrane?
w q wq wq wq wq wq wq wq wq wq
a. 52% protein, 40% lipid, 8% carbohydrate wq wq wq wq wq
b. 40% protein, 8% lipid, 52% carbohydrate wq wq wq wq wq
c. 8% protein, 52% lipid, 40% carbohydrate wq wq wq wq wq
d. 8% lipid, 40% carbohydrate, 52% protein wq wq wq wq wq
wq 11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
w q wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
except:
a. Decreased pH. c. Increased ATP level. wq wq wq
b. Loss of red blood cell function. d. Decreased glucose consumption.
wq wq wq wq wq w q wq wq
wq 12. Which red blood cell preservative has a storage time of 35 days?
w q wq wq wq wq wq wq wq wq wq wq wq
a. ACD c. AS-1
b. CPDA-1 d. CPD
wq 13. The RBC membrane is relatively permeable to all of the following except:
w q wq wq wq wq wq wq wq wq wq wq wq
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water. w q
14. What percentage of platelets is sequestered in the spleen as functional reserve after being released fromK t
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq w q
he bone marrow? wq wq
a. 30% c. 10%
b. 50% d. 25%
wq 15. What is the major biochemical consideration in plateletKstorage?
w q wq wq wq wq wq wq wq
a. Glucose metabolism c. Production of carbon dioxidewq wq wq wq
b. Oxygen supply d.K Regulation ofKpH wq w q w q
16. What would the hemoglobin-
wq wq wq wq wq
oxygen dissociation curve depict in aKpatient exhibitingKclinical signs of alkalosis?
wq wq wq wq wq wq wq wq wq
a. Normal c. Shift toKthe right wq wq
b. Shift to the left d.K None of the above
wq wq wq w q wq wq wq
wq 17. Name the main lipid components of a red blood cell membrane.
w q wq wq wq wq wq wq wq wq wq wq
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A w q wq
wq 18. The ABO bloodKgroups were discovered in 1901 by whom?
w q wq wq wq wq wq wq wq wq
a. CharlesKDrew c. Loutit and Mollison wq wq
b. KarlKLandsteiner d. Edward Lindeman w q wq
wq 19. A standing order of plateletsKwas shipped to your facility by your supplier. It was inadvertently left in t
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
h e corner of the departmentKuntil discovered 36 hours later. What would the appropriate action be for the b
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
lood banker? wq
a. If the temperature in the box was 22 +/-
wq wq wq wq wq wq wq wq
2°C and the platelet swirl seemed OK, it would be OK to accept the unit into inventor y
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
.
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be dis
wq wq wq wq wq wq wq wq wq wq wq wq wq
carded because the pH has probably dropped too low and platelet activation has be en c
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
ompromised.
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK to
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
wq wq wq wq w q wq w q wq w q w q
2021 17:54:15 GMT -
w q w q wq
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
accept the unit into inventory. wq wq wq wq
d. If the platelets appeared OK and passed the platelet swirl test after being placed on th
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
e agitator, they could be accepted into the inventory.
wq wq wq wq wq wq wq wq
20. Which metabolic pathway permits the accumulation of 2,3 diphosphoglycerate (2,3-DPG)?
wq w q wq wq wq wq wq wq wq wq wq
a. Glycolysis c. Pentose phosphate shunt wq wq
b. Luebering-Rapoport shunt d. Methemoglobin reductase wq w q wq
21. All of the following are consistent with a "shift to the right" of the hemoglobin-oxygen dissociation curve
wq w q wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
except:
a. Increased 2,3-DPG. wq
b. 50% O2 saturation to tissues. wq w q wq wq
c. Decreased 2,3-DPG. wq
d. Decreased hemoglobin affinity for O2. wq wq wq wq
wq 22. What is the normal platelet count range per cubic millimeter?
w q wq wq wq wq wq wq wq wq wq
a. 100 to 350 wq c. 50,000 to 200,000
wq wq wq
b. 150,000 to 350,000 d. 350,000 to 500,000 wq wq w q wq wq
wq 23. What cryoprotective agent is added to red blood cells upon freezing?
w q wq wq wq wq wq wq wq wq wq wq
a. Dextrose c. Glycerol
b. Adsol d. All of the above w q wq wq wq
24. If platelets are to be stored for 5 days on a rotator, what isKtheKoptimal storageKtemperature?
wq w q wq wq wq wq wq wq wq wq wq wq wq wq wq wq
a. 1°C to 6°C c. 35°CKto 37°C
wq wq wq
b. 20°C to 24°C d. 1°C toK10°C
wq wq w q wq
wq 25. What role do platelets play in hemostasis?
w q wq wq wq wq wq wq
a. Maintenance of vascular integrity wq wq wq
b. Initial arrest of bleeding by platelet plugKformation wq wq wq wq wq wq
c. Stabilization of the hemostatic plug wq wq wq wq
d. All of the above wq wq wq
wq 26. Which of the following best describes "integral"Kmembrane proteins?
w q wq wq wq wq wq wq wq
a. Reside at the cytoplasmicKsurface of membrane wq wq wq wq wq
b. Span the entire membrane surface wq wq wq wq
c. Form the red bloodKcellKcytoskeleton wq wq wq
d. None of the above wq wq wq
wq 27. How is stroma-freeKhemoglobin solution prepared?
w q wq wq wq wq
a. OutdatedKred blood cells are concentrated, and stroma is removed. wq wq wq wq wq wq wq wq
b. Outdated red blood cellsKare diluted with saline, and stroma is removed. wq wq wq wq wq wq wq wq wq wq
c. OutdatedKred blood cellsKare lysed, and stroma is removed. wq wq wq wq wq wq wq
d. None of the above wq wq wq
wq 28. What is the normal lifeKspan of an RBC?
w q wq wq wq wq wq wq wq
a. 100 days wq c. 120 hours wq
b. 120 days wq d. 2 days
w q w q wq
wq 29. Regarding loss of RBC membrane deformability, all of the following are true except:
w q wq wq wq wq wq wq wq wq wq wq wq wq
a. Increase in ATP level. wq wq wq
b. Decrease in ATP level. wq wq wq
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
wq wq wq wq w q wq w q wq w q w q
2021 17:54:15 GMT -
w q w q wq
https://www.coursehero.com/file/25537437/ch01rtf/
TRANSFUSIONPRACTICES7THEDITIONBY
DENISEMHARMENING
9780803668881CHAPTER1-29COMPLETE
GUIDE
,https://www.stuvia.com/
Chapter 1 RBCs and Platelet Preservation: Historical Perspectives and Current Trends
wq wq wq wq wq wq wq wq wq wq
Multiple Choicewq
Identify the choice that best completes the statement or answers the question.
wq wq wq wq wq wq wq wq wq wq wq
1. Which metabolic pathway is responsible for generating 90% of the ATP for the RBC?
wq wq wq wq wq wq wq wq wq wq wq wq wq
a. Pentose phosphate shunt c. Glycolysis wq wq
b. Luebering-Rapoport shunt d. Methemoglobin reductase wq w q wq
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed. The
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most a ccurate
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
?
a. The unit of blood should be discarded immediately. wq wq wq wq wq wq wq
b. The unit of blood can be returned to inventory. wq wq wq wq wq wq wq wq
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
d. The unit of blood must be transfused with 24 hours.wq wq wq wq wq wq wq wq wq
3. What is the average diameter of a platelet?
wq wq wq wq wq wq wq
a. 5 to 10 µm wq wq wq c. 1 to 2 µm wq wq wq
b. 2 to 4 µm wq wq wq d. 4 to 6 µm wq wq wq
4. In the normal hemoglobin-
wq wq wq
oxygen dissociation curve, what percentage of oxygen is releasedKto the tissuesKwhen PO2 averages 4
wq wq wq wq wq wq wq wq wq wq wq w q wq
0 mm Hg? w q wq wq
a. 75% c. 100%
b. 25% d. 50% w q w q
5. What factors are known to influence platelet metabolism and function?
wq wq wq wq wq wq wq wq wq
a. Storage temperature c. Platelet count wq wq
b. Initial pH d. All of theKabove wq w q wq wq
6. Which of the following red blood cellKmorphologies mayKbeKpresent on the peripheral blood smear as a re su
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
lt of loss of RBC membrane?
wq wq wq wq wq
a. Spherocytes c. Burr cells wq
b. Target cells d. Schistocytes wq w q
7. What does the term autologous transfusionKrefer to?
wq wq wq wq wq wq
a. A parent donating blood for his orKher child
wq wq wq wq wq wq wq
b. An individualKdonating bloodKfor a friend wq wq wq wq
c. An individualKdonating blood forKa relative wq wq wq wq
d. AnKindividual donating bloodKfor his or her own transfusion wq wq wq wq wq wq wq
8. What is theKprimary functionKof hemoglobin?
wq wq wq wq
a. Iron metabolism c. Oxygen transport
wq wq
b. Porphyrin synthesis d. Signal transduction wq w q wq
9. All of the followingKareas of red blood cell biology are crucial for normal erythrocyte survival except:
wq wq wq wq wq wq wq wq wq wq wq wq wq wq w q
a. Cellular metabolism. c. Site of the ABO antigen attachment.
wq wq wq wq wq wq
b. RBC membrane. d. Hemoglobin structure.
wq w q wq
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
wq wq wq wq w q wq w q wq w q w q
2021 17:54:15 GMT -
w q w q wq
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
wq 10. What is the correct biochemical composition of the RBC membrane?
w q wq wq wq wq wq wq wq wq wq
a. 52% protein, 40% lipid, 8% carbohydrate wq wq wq wq wq
b. 40% protein, 8% lipid, 52% carbohydrate wq wq wq wq wq
c. 8% protein, 52% lipid, 40% carbohydrate wq wq wq wq wq
d. 8% lipid, 40% carbohydrate, 52% protein wq wq wq wq wq
wq 11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
w q wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
except:
a. Decreased pH. c. Increased ATP level. wq wq wq
b. Loss of red blood cell function. d. Decreased glucose consumption.
wq wq wq wq wq w q wq wq
wq 12. Which red blood cell preservative has a storage time of 35 days?
w q wq wq wq wq wq wq wq wq wq wq wq
a. ACD c. AS-1
b. CPDA-1 d. CPD
wq 13. The RBC membrane is relatively permeable to all of the following except:
w q wq wq wq wq wq wq wq wq wq wq wq
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water. w q
14. What percentage of platelets is sequestered in the spleen as functional reserve after being released fromK t
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq w q
he bone marrow? wq wq
a. 30% c. 10%
b. 50% d. 25%
wq 15. What is the major biochemical consideration in plateletKstorage?
w q wq wq wq wq wq wq wq
a. Glucose metabolism c. Production of carbon dioxidewq wq wq wq
b. Oxygen supply d.K Regulation ofKpH wq w q w q
16. What would the hemoglobin-
wq wq wq wq wq
oxygen dissociation curve depict in aKpatient exhibitingKclinical signs of alkalosis?
wq wq wq wq wq wq wq wq wq
a. Normal c. Shift toKthe right wq wq
b. Shift to the left d.K None of the above
wq wq wq w q wq wq wq
wq 17. Name the main lipid components of a red blood cell membrane.
w q wq wq wq wq wq wq wq wq wq wq
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A w q wq
wq 18. The ABO bloodKgroups were discovered in 1901 by whom?
w q wq wq wq wq wq wq wq wq
a. CharlesKDrew c. Loutit and Mollison wq wq
b. KarlKLandsteiner d. Edward Lindeman w q wq
wq 19. A standing order of plateletsKwas shipped to your facility by your supplier. It was inadvertently left in t
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
h e corner of the departmentKuntil discovered 36 hours later. What would the appropriate action be for the b
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
lood banker? wq
a. If the temperature in the box was 22 +/-
wq wq wq wq wq wq wq wq
2°C and the platelet swirl seemed OK, it would be OK to accept the unit into inventor y
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
.
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be dis
wq wq wq wq wq wq wq wq wq wq wq wq wq
carded because the pH has probably dropped too low and platelet activation has be en c
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
ompromised.
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK to
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
wq wq wq wq w q wq w q wq w q w q
2021 17:54:15 GMT -
w q w q wq
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
accept the unit into inventory. wq wq wq wq
d. If the platelets appeared OK and passed the platelet swirl test after being placed on th
wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
e agitator, they could be accepted into the inventory.
wq wq wq wq wq wq wq wq
20. Which metabolic pathway permits the accumulation of 2,3 diphosphoglycerate (2,3-DPG)?
wq w q wq wq wq wq wq wq wq wq wq
a. Glycolysis c. Pentose phosphate shunt wq wq
b. Luebering-Rapoport shunt d. Methemoglobin reductase wq w q wq
21. All of the following are consistent with a "shift to the right" of the hemoglobin-oxygen dissociation curve
wq w q wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq wq
except:
a. Increased 2,3-DPG. wq
b. 50% O2 saturation to tissues. wq w q wq wq
c. Decreased 2,3-DPG. wq
d. Decreased hemoglobin affinity for O2. wq wq wq wq
wq 22. What is the normal platelet count range per cubic millimeter?
w q wq wq wq wq wq wq wq wq wq
a. 100 to 350 wq c. 50,000 to 200,000
wq wq wq
b. 150,000 to 350,000 d. 350,000 to 500,000 wq wq w q wq wq
wq 23. What cryoprotective agent is added to red blood cells upon freezing?
w q wq wq wq wq wq wq wq wq wq wq
a. Dextrose c. Glycerol
b. Adsol d. All of the above w q wq wq wq
24. If platelets are to be stored for 5 days on a rotator, what isKtheKoptimal storageKtemperature?
wq w q wq wq wq wq wq wq wq wq wq wq wq wq wq wq
a. 1°C to 6°C c. 35°CKto 37°C
wq wq wq
b. 20°C to 24°C d. 1°C toK10°C
wq wq w q wq
wq 25. What role do platelets play in hemostasis?
w q wq wq wq wq wq wq
a. Maintenance of vascular integrity wq wq wq
b. Initial arrest of bleeding by platelet plugKformation wq wq wq wq wq wq
c. Stabilization of the hemostatic plug wq wq wq wq
d. All of the above wq wq wq
wq 26. Which of the following best describes "integral"Kmembrane proteins?
w q wq wq wq wq wq wq wq
a. Reside at the cytoplasmicKsurface of membrane wq wq wq wq wq
b. Span the entire membrane surface wq wq wq wq
c. Form the red bloodKcellKcytoskeleton wq wq wq
d. None of the above wq wq wq
wq 27. How is stroma-freeKhemoglobin solution prepared?
w q wq wq wq wq
a. OutdatedKred blood cells are concentrated, and stroma is removed. wq wq wq wq wq wq wq wq
b. Outdated red blood cellsKare diluted with saline, and stroma is removed. wq wq wq wq wq wq wq wq wq wq
c. OutdatedKred blood cellsKare lysed, and stroma is removed. wq wq wq wq wq wq wq
d. None of the above wq wq wq
wq 28. What is the normal lifeKspan of an RBC?
w q wq wq wq wq wq wq wq
a. 100 days wq c. 120 hours wq
b. 120 days wq d. 2 days
w q w q wq
wq 29. Regarding loss of RBC membrane deformability, all of the following are true except:
w q wq wq wq wq wq wq wq wq wq wq wq wq
a. Increase in ATP level. wq wq wq
b. Decrease in ATP level. wq wq wq
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-
wq wq wq wq w q wq w q wq w q w q
2021 17:54:15 GMT -
w q w q wq
https://www.coursehero.com/file/25537437/ch01rtf/
