Page 1 of 91
COMSAE Phase 1 Form C115 – Exam ACTUAL EXAM
COMPLETE 200 QUESTIONS AND VERIFIED
SOLUTIONS LATEST UPDATE THIS YEAR
COMSAE Phase 1 Form C115 –
Exam Coverage Areas
• Anatomy & Embryology (including neuroanatomy)
• Physiology (cardiovascular, respiratory, renal, endocrine, GI, neurophysiology)
• Biochemistry & Molecular Biology
• Microbiology & Immunology
• Pharmacology (mechanism, indications, adverse effects)
• Pathology (cell injury, inflammation, neoplasia)
• Behavioral Sciences, Genetics, Ethics
• Clinical Correlations / Organ System Integration
1. A 23-year-old woman develops right lower quadrant pain, fever, and leukocytosis.
Tenderness is noted at McBurney’s point. Which structure is most likely inflamed?
,Page 2 of 91
A. Cecum
B. Appendix
C. Ileum
D. Sigmoid colon
Answer: B
Rationale: McBurney’s point corresponds to the base of the appendix; RLQ pain and
leukocytosis suggest acute appendicitis.
2. A 58-year-old man with long-standing hypertension develops left ventricular hypertrophy.
Which cellular adaptation occurred?
A. Hyperplasia
B. Hypertrophy
C. Atrophy
D. Metaplasia
Answer: B
Rationale: Chronic pressure overload induces hypertrophy (increase in cell size) in cardiac
myocytes.
3. Which cranial nerve is responsible for the corneal reflex?
,Page 3 of 91
A. CN II
B. CN V and CN VII
C. CN IX
D. CN X
Answer: B
Rationale: Afferent (sensory) limb is CN V1 (ophthalmic branch of trigeminal); efferent (motor)
limb is CN VII (facial nerve).
4. Which electrolyte abnormality is most likely in Addison’s disease?
A. Hypernatremia
B. Hyperkalemia
C. Hypokalemia
D. Hypercalcemia
Answer: B
Rationale: Mineralocorticoid deficiency causes sodium loss and potassium retention, leading to
hyperkalemia.
5. Which bacterium is a Gram-positive cocci in chains that causes rheumatic fever?
A. Staphylococcus aureus
B. Streptococcus pyogenes
, Page 4 of 91
C. Enterococcus faecalis
D. Streptococcus pneumoniae
Answer: B
Rationale: Streptococcus pyogenes (Group A strep) can trigger autoimmune complications like
rheumatic fever.
6. A patient taking a statin develops muscle pain and elevated CK. Which enzyme deficiency
or interaction could worsen this effect?
A. CYP3A4 inhibition
B. CYP2D6 induction
C. Acetylcholinesterase inhibition
D. Monoamine oxidase deficiency
Answer: A
Rationale: CYP3A4 metabolizes many statins; inhibition increases serum levels, risking
myopathy.
7. Which cell type is primarily responsible for humoral immunity?
A. T helper cells
B. B lymphocytes
C. Natural killer cells
COMSAE Phase 1 Form C115 – Exam ACTUAL EXAM
COMPLETE 200 QUESTIONS AND VERIFIED
SOLUTIONS LATEST UPDATE THIS YEAR
COMSAE Phase 1 Form C115 –
Exam Coverage Areas
• Anatomy & Embryology (including neuroanatomy)
• Physiology (cardiovascular, respiratory, renal, endocrine, GI, neurophysiology)
• Biochemistry & Molecular Biology
• Microbiology & Immunology
• Pharmacology (mechanism, indications, adverse effects)
• Pathology (cell injury, inflammation, neoplasia)
• Behavioral Sciences, Genetics, Ethics
• Clinical Correlations / Organ System Integration
1. A 23-year-old woman develops right lower quadrant pain, fever, and leukocytosis.
Tenderness is noted at McBurney’s point. Which structure is most likely inflamed?
,Page 2 of 91
A. Cecum
B. Appendix
C. Ileum
D. Sigmoid colon
Answer: B
Rationale: McBurney’s point corresponds to the base of the appendix; RLQ pain and
leukocytosis suggest acute appendicitis.
2. A 58-year-old man with long-standing hypertension develops left ventricular hypertrophy.
Which cellular adaptation occurred?
A. Hyperplasia
B. Hypertrophy
C. Atrophy
D. Metaplasia
Answer: B
Rationale: Chronic pressure overload induces hypertrophy (increase in cell size) in cardiac
myocytes.
3. Which cranial nerve is responsible for the corneal reflex?
,Page 3 of 91
A. CN II
B. CN V and CN VII
C. CN IX
D. CN X
Answer: B
Rationale: Afferent (sensory) limb is CN V1 (ophthalmic branch of trigeminal); efferent (motor)
limb is CN VII (facial nerve).
4. Which electrolyte abnormality is most likely in Addison’s disease?
A. Hypernatremia
B. Hyperkalemia
C. Hypokalemia
D. Hypercalcemia
Answer: B
Rationale: Mineralocorticoid deficiency causes sodium loss and potassium retention, leading to
hyperkalemia.
5. Which bacterium is a Gram-positive cocci in chains that causes rheumatic fever?
A. Staphylococcus aureus
B. Streptococcus pyogenes
, Page 4 of 91
C. Enterococcus faecalis
D. Streptococcus pneumoniae
Answer: B
Rationale: Streptococcus pyogenes (Group A strep) can trigger autoimmune complications like
rheumatic fever.
6. A patient taking a statin develops muscle pain and elevated CK. Which enzyme deficiency
or interaction could worsen this effect?
A. CYP3A4 inhibition
B. CYP2D6 induction
C. Acetylcholinesterase inhibition
D. Monoamine oxidase deficiency
Answer: A
Rationale: CYP3A4 metabolizes many statins; inhibition increases serum levels, risking
myopathy.
7. Which cell type is primarily responsible for humoral immunity?
A. T helper cells
B. B lymphocytes
C. Natural killer cells
