Genotype Frequency, Phenotype Frequency,
Homozygous Dominant (p²), Heterozygous (2pq),
Homozygous Recessive (q²), Autosomal Recessive
Disease, Carrier Frequency, p + q = 1, HW
Equilibrium Conditions, Random Mating, No
Mutation, No Selection, Large Population, No
Migration, Genetic Drift, Founder Effect, Bottleneck
Effect, Tay-Sachs, Gaucher Disease, Ellis-Van
Creveld Syndrome, Sickle Cell Anemia, Natural
Selection, Gene Flow/Migration, Consanguinity,
PKU, Cystic Fibrosis Verified Exam Questions
Provided with A+ Graded Rationales Latest
Updated 2026
Allele frequency
Qstn stem may be worded:
"What is the frequency of homozygote wild type (p2)?"
"What is the frequency of disease-causing alleles (2p+q2)"?
% 1 allele occurs in a gene pool
or
Proportion of a particular allele in a population
Phenotype frequency
Qstn stem may be worded:
"What is the frequency of disease (q2)"?
% of one type of individual in the population
or
Proportion of individuals in a population that are of a certain phenotype
Genotype Frequency
Qstn stem may be worded:
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, "What is the carrier frequency (2pq)"
Proportion of individuals in a population that are of a certain phenotype
what is the phenotype frequency for autosomal recessive conditions? (HY/TQ)
the proportion of a particular phenotype in the population (q^2)
*homozygous recessive*
Hardy Weinberg Equation & Terms
2pq
p^2
q^2
p+q=
p^2 + 2pq + q^2 = 1
frequency of heterozygous genotype
frequency of homozygous dominant
frequency of homozygous recessive
w/ phenotype frequency
*Autosomal recessive disease*
p + q= 1
5 conditions for Hardy-Weinberg Equilibrium
1. No mutations
2. Random mating
3. No natural selection
4. Extremely large population size
5. No gene flow/migration
How is genotype frequency calculated?
take the number of individuals with the specified genotype and divide it by the total population
#
EX:
AA = 647
Total = 788
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