NUR 521 ADVANCED PHARMACOLOGY EXAM 4 | Complete Questions And Correct Answers (Verified) | LATEST UPDATE | Graded A+ |Brand New!!

NUR 521 ADVANCED PHARMACOLOGY EXAM 4 | Complete Questions And Correct Answers (Verified) | LATEST UPDATE | Graded A+ |Brand New!! Enbrel Indications: - ANSWER-* Rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis; * Plaque psoriasis * Polyarticular juvenile idiopathic arthritis in children Enbrel CI: - ANSWER-* Hypersensitivity to drug or ingredient, granulomatosis w/polyangiitis Enbrel Precautions: - ANSWER-* Chronic or recurrent infection, 65 yo, uncontrolloed diabetes mellitus, TB, HBV, malignancy Tofacitinib (Xeljanz) MOA: - ANSWER-* Inhibits janus-associated kinases (JAK) 1, 2, and 3, leading to disruption of cytokine and growth factor signaling pathways * DMARD Xeljanz BBW: - ANSWER-* Risk of infection, malignancies, cardiovascular events, thrombosis; * Weigh risk/benefit during pregnancy and female pts of reproductive potential; avoid breastfeeding Xeljanz Pharmacokinetics: - ANSWER-* Metabolized in the liver, excreted in the urine Xeljanz Indications: - ANSWER-* Rheumatoid arthritis 2 | P a g e Xeljanz CI: - ANSWER-* Hypersensitivity to drug or ingredient * Baseline Hgb 9 * Lymphocytes 500 * Baseline ANC 1000 * Active infection * Hepatic impairment Enbrel Patient Education: - ANSWER-* Delivery: Etanercept is injected under the skin * Monitoring: Hepatitis B serology incl. HBsAg at baseline; TB at baseline, then periodically Enbrel Evaluation: - ANSWER-* Side Effects: * Monitor for fever, chills, flu symptoms, pale skin, easy bruising or bleeding; pain, redness or swelling at injection site; signs of lymphoma including fever, night sweats, weight loss, swollen glands; signs of TB Xeljanz Precaution: - ANSWER-* Renal, hepatic impairment * Chronic or recurrent infection * Active or latent TB * Chronic lung dz * HBV * HCV * Smokers Xeljanz Patient Education: - ANSWER-Monitoring: hepatitis panel, CBC w/diff, TB test, LFT's Xeljanz Evaluation: - ANSWER-* Side Effects: -- SOB -- Nausea -- Vomiting 3 | P a g e -- Cold sweat -- Weakness on one side of body -- Slurred speech -- Skin rash -- Shingles -- Increased BP -- Fever -- Headache -- N/V/D Zyloprim Indications: - ANSWER-* Gout * Recurrent kidney stones Zyloprim CI: - ANSWER-* Hypersensitivity to drug or ingredient * Avoid breastfeeding Zyloprim Precautions: - ANSWER-* Use caution among African American pts, Han Chinese, Korean, Thai, and Pacific Islander, renal or hepatic impairment Zyloprim Patient Education: - ANSWER-* Symptoms may not improve for up to 2 to 6 weeks * Take with a full glass of water and with food to decrease risk of kidney stones Allopurinol (Zyloprim) MOA: - ANSWER-* Inhibits xanthine oxidase, interfering w/ conversion of hypoxanthine and xanthine to uric acid * Xanthine Oxidase Inhibitor Zyloprim Safety: - ANSWER-* BUN/Cr at baseline then periodically * LFT's during early tx if hepatic disease 4 | P a g e Zyloprim Pharmacokinetics: - ANSWER-* Metabolized in the liver, excreted in the urine primarily * Drug Interactions: Delays the metabolism of warfarin, azathioprine, theophylline Zyloprim Monitoring: - ANSWER-* Kidney and liver function * Can cause bone marrow suppression, hepatotoxicity and hypersensitivity Benuryl Safety: - ANSWER-* Do not use if allergic, a gout attack that has already started, uric acid kidney stones anemia or low white blood cells. Benuryl Pharmacokinetics: - ANSWER-* Metabolized in the liver, excreted in the urine Benuryl Indications: - ANSWER-* Gout; sometimes given together with penicillin antibiotics to make them more effective. Benuryl CI: - ANSWER-* Hypersensitivity * CrCL 30 * Uric Acid stones * Blood dyscrasia * Gout attack * Ketorolac is contraindicated. Benuryl Precautions: - ANSWER-* Hypersensitivity to sulfa * Renal impairment * PUD * ASA, indomethacin, sulfonamides 5 | P a g e Benuryl Patient Education: - ANSWER-* Monitoring: -- Cr at baseline -- CBC Zyloprim Evaluation: - ANSWER-* Side Effects: -- Skin rxn -- Exfoliative dermatitis -- Rash -- Nausea -- Diarrhea -- Injection site reaction Probenecid (Benuryl) MOA: - ANSWER-* Inhibits renal tubular urate resorption; prolong the effects of penicillin and cephalosporin by delaying their excretion by the kidneys. * Uricosuric Agent Benuryl Evaluation: - ANSWER-* Side Effects: