Low-Molecular-Weight Heparin (LMWH),
Enoxaparin (Lovenox), Heparin-Induced
Thrombocytopenia (HIT), Protamine Sulfate
Reversal, Warfarin (Coumadin) Therapy, Vitamin K
Antagonist, INR Monitoring, Major Bleeding Risk,
Clopidogrel (Plavix), Antiplatelet Therapy, CYP450
Genetic Variability, Dual Antiplatelet
Considerations, Alteplase (t-PA), Thrombolytic
Therapy, Ischemic Stroke Management, Myocardial
Infarction Treatment Window, Fibrinolysis
Mechanism, Hemorrhagic Complications, Herbal
Drug Interactions (Ginkgo Garlic Ginger),
Pregnancy Category Risks, Epidural Hematoma
Warning, Medication Safety and Monitoring,
Comprehensive Antithrombotic Management Exam
Questions Verified and Complete with A+ Graded
Rationales Latest Updated 2026
Heparin Class
Anticoagulant (Parenteral)
Heparin Action/Use
- No ability to dissolve clots
- IV is immediate
- Prevent thromembolic events
- Treat conditions that need immediate anticoagulation
Heparin Administration Alert
- Poorly absorbs in GI
- Admin: SubQ or IV
- Heparin nomogram system calculates dose
, - Never draw back the syringe plunger once the needle has entered the skin
- Never massage the site after injection
- Pregnancy Category C
Heparin Adverse Effects
- Bleeding
- Heparin-Induced Thrombocytopenia (HIT)
Heparin BBW
- Epidural or spina hematoma when receiving spinal anesthesia
- Can result in long-term or permanent paralysis
Heparin Contraindications
- Active internal bleeding
- Bleeding disorders
- Severe HTN
- Recent trauma
- Intracranial hemorrhage
- Bacterial endocarditis
Heparin Interactions
- Oral anticoagulants potentiate action
- Ginger
- Garlic
- Green tea
- Feverfew
- Ginkgo
Heparin OD Treatment
- Protamine sulfate
- IV 1 mg for ever 100 units of heparin
LMWH
- Enoxaparin (Lovenox)
- SubQ
- Duration 2-4x longer
- More stable response
Warfarin class