Hemostasis Questions With Complete Solutions

Hemostasis Questions With Complete Solutions


Thrombin will convert
Fibrinogen (I) to Fibrin (IIa)
Fibrin monomers are stabilized into polymers necessary for clot
formation via
-Ca2+ (factor IV)
-fibrin stabilizing factor (factor XIII)
liver synthesizes bile salts which absorb ____ to produce ____
-vitamin K
-prothrombin
only clotting factors not made in liver are
factor VIII + von wildebrand
3 mechanisms for opposing clot formation
-tissue factor pathway inhibitor
-protein C
-antithrombin III
tissue factor pathway inhibitor (TFPI)
-made by liver
-Occurs at start of clotting and uses plasma protein TFPI
-This is the cause for small amount of Thrombin produced by
Extrinsic Pathway
tissue factor pathway inhibitor (TFPI) binds to ____ and inhibits
_____

, -tissue factor-VIIa complex
-generation of Xa
protein C
-made by liver
1. Thrombin binds to Thrombomodulin = deactivates clotting
ability
2. thrombin binds to protein C
3. protein C inactivates Va + VIIIa = prevents platelet activation
Antithrombin III
-Plasma protein
-inactivates Thrombin and IXa, Xa, XIa, XIIa (9-11)
-Enhanced when bound to Heparin
Fibrinolytic System
-removes clots that are already formed.
-tissue plasminogen activator (t-PA) catalyzes activation
1. Plasminogen is activated into Plasmin
2. Plasmin digests Fibrin and dissolves the clot
role of endothelial cells on anticlotting
-barrier to subendothelial tissue
-release prostacyclin + nitric oxide
-secrete TFPI
-bind thrombin via thrombomodulin
-display heparin
-release t-PA
hemostasis