ASCP(MB) (by smockus), MB
(ASCP) Practice Exam Questions
and Answers 100% PASS
Genes involved in cancer caused by t(9;22)—ANSWER-BCR-ABL
Cancer caused by t(9:22)—ANSWER-CML
Genes involved in cancer caused by t(11;22)—ANSWER-EWS-FLI1
Cancer caused by translocations involving 22q12—ANSWER-Ewing sarcoma
Receptor tyrosine kinase commonly overexpressed in breast cancer—ANSWER-HER2(ERBB2)
- 17q21.1
Methods used to assess overexpression of common oncogenes—ANSWER-IHC, rtPCR, FISH
Most common oncogene in human cancer, which activates MAPK pathway—ANSWER-KRAS
Most common translocation in 85% of Ewing's sarcoma—ANSWER-t(11,22)(q24,q12)
80% of this type of cancer is caused by t(X;18)—ANSWER-Synovial sarcoma
Inherited mutations in this gene cause Li-Fraumeni syndrome—ANSWER-TP53
, Mutations in this gene increase lifetime risk of developing breast or ovarian cancer to 60-
80%—ANSWER-BRCA1
Point mutations in this gene cause multiple endocrine neoplasia—ANSWER-RET
Translocations involving this gene commonly cause papillary carcinoma—ANSWER-RET
Alterations in this gene lead to a syndrome, which predisposes to renal cell carcinoma—
ANSWER-VHL
This type of cancer is associated with a defective mismatch repair system (MMR)—ANSWER-
Colon cancer
MSI is often associated (90%) with this type of inherited cancer—ANSWER-Hereditary
nonpolyposis colorectal cancer (HNPCC) aka Lynch syndrome
How many repeat loci are analyzed to determine MSI?—ANSWER-Five
In MSI testing 2 of 5 loci must show instability to classify it to this degree (MSH-H or MSH-
L)—ANSWER-High
Two gene associated with the cancer, HNPCC—ANSWER-MSH2 and MLH1
A ratio of less than ____ and greater than ____ indicates of loss of heterozygosity (LOH)—
ANSWER-0.5 and 2
Common translocation in follicular lymphoma—ANSWER-t(14;18)
This gene is often involved in translocations in follicular lymphoma—ANSWER-BCL2
This translocation is also known as the Philadelphia chromosome—ANSWER-t(9;22)
Two genes commonly translocated in acute promyelocytic leukemia—ANSWER-PML/RARA
© 2026 Copyright. All Rights Reserved. This document is
protected by copyright law, Copyrighted By Brittie Donald
(ASCP) Practice Exam Questions
and Answers 100% PASS
Genes involved in cancer caused by t(9;22)—ANSWER-BCR-ABL
Cancer caused by t(9:22)—ANSWER-CML
Genes involved in cancer caused by t(11;22)—ANSWER-EWS-FLI1
Cancer caused by translocations involving 22q12—ANSWER-Ewing sarcoma
Receptor tyrosine kinase commonly overexpressed in breast cancer—ANSWER-HER2(ERBB2)
- 17q21.1
Methods used to assess overexpression of common oncogenes—ANSWER-IHC, rtPCR, FISH
Most common oncogene in human cancer, which activates MAPK pathway—ANSWER-KRAS
Most common translocation in 85% of Ewing's sarcoma—ANSWER-t(11,22)(q24,q12)
80% of this type of cancer is caused by t(X;18)—ANSWER-Synovial sarcoma
Inherited mutations in this gene cause Li-Fraumeni syndrome—ANSWER-TP53
, Mutations in this gene increase lifetime risk of developing breast or ovarian cancer to 60-
80%—ANSWER-BRCA1
Point mutations in this gene cause multiple endocrine neoplasia—ANSWER-RET
Translocations involving this gene commonly cause papillary carcinoma—ANSWER-RET
Alterations in this gene lead to a syndrome, which predisposes to renal cell carcinoma—
ANSWER-VHL
This type of cancer is associated with a defective mismatch repair system (MMR)—ANSWER-
Colon cancer
MSI is often associated (90%) with this type of inherited cancer—ANSWER-Hereditary
nonpolyposis colorectal cancer (HNPCC) aka Lynch syndrome
How many repeat loci are analyzed to determine MSI?—ANSWER-Five
In MSI testing 2 of 5 loci must show instability to classify it to this degree (MSH-H or MSH-
L)—ANSWER-High
Two gene associated with the cancer, HNPCC—ANSWER-MSH2 and MLH1
A ratio of less than ____ and greater than ____ indicates of loss of heterozygosity (LOH)—
ANSWER-0.5 and 2
Common translocation in follicular lymphoma—ANSWER-t(14;18)
This gene is often involved in translocations in follicular lymphoma—ANSWER-BCL2
This translocation is also known as the Philadelphia chromosome—ANSWER-t(9;22)
Two genes commonly translocated in acute promyelocytic leukemia—ANSWER-PML/RARA
© 2026 Copyright. All Rights Reserved. This document is
protected by copyright law, Copyrighted By Brittie Donald
