QUESTIONS WITH VERIFIED ANSWERS
1. What labs would you complete to Rule Out Alzheimer's Disease? (5) -
ANSWER 1. CBC
Metabolic Panel
Vitamins B12 and Folate
RPR Test
TSH
2. Why would an RPR Test be completed to rule out Alzheimer's? - ANSWER
RPR Test is to help rule of Syphilis
3. Brain imagining like a CT or MRI should be done in someone who is
suspected of having Alzheimer's, True or False. - ANSWER True
these imaging studies are essential in order to rule out brain, pathology, or
identify structural abnormalities
4. Rapid progression or onset of Alzheimer's before age 80 is a red flag and the
patient should be referred to Neurology, True or False? - ANSWER False
5. Rapid progression or onset of Alzheimer's before age 60 is a red flag
6. What is the First-Line medication used for Alzheimer's disease? -
ANSWER Cholinesterase Inhibitors
,7. What's the MOA of the Cholinesterase Inhibitors? - ANSWER Prevent the
breakdown of acetylcholine, improving neurotransmissions.
8. What is the initial dose of Donepezil used for Alzheimer's? (What time of
day) - ANSWER Initial dose is 5mg at Bedtime
9. What is the Titration of Donepezil? - ANSWER Increased to 10mg after 4-6
weeks
10.What is the max dose of Donepezil? - ANSWER 23mg/day
11.What is the initial dose of Galantamine? - ANSWER 4mg twice daily
12.What is the titration of Galantamine? - ANSWER Extended release 8mg
once daily
13.What is the initial dose of Rivastigmine? - ANSWER The initial dose is
1.5mg
14.What is the dose is the dose of the transdermal patch of Rivastigmine? How
often does it need to be changed? - ANSWER 4.6mg changed every 24
hours
15.What are some side effects of Rivastigmine? - ANSWER Anorexia
Weight loss
Nausea and vomiting
Loss of appetite
Dehydration
,Headaches
AV Block
16.What medication is Second Line for Adjunct Therapy for Alzheimer's
disease? - ANSWER Memantine
17.What's the initial dosing of Memantine? - ANSWER Initial dose 5mg daily
18.What is the titration for Memantine? - ANSWER Titrate 10mg daily, then
10mg twice daily over 4 weeks
19.What imaging is used to visualized the infarcts cause by Vascular Dementia?
- ANSWER CT or MRI of the brain
20.What's the etiology of Lewy Body Dementia? - ANSWER Lewy bodies are
abnormal clumps of a protein called Alpha synuclein that build up in the
neurons. The proteins damage the neurons and interfere with the availability
of acetylcholine.
21.How do cholinesterase inhibitors help the symptoms of Lewy Body
Dementia? - ANSWER Cholinesterase inhibitors help by increasing the
availability of acetylcholine
22.Charles is a 75-year-old man. He has been diagnosed with Alzheimer's
disease. He is currently presenting some new symptoms such as muscle
stiffness and pill rolling tremor. What if the following medications would be
best to cater to his symptoms?
A. Donepezil
, B. Rivastigmine
C. Galantamine
D. Levadopa
E. Memantine - ANSWER D. Levadopa
23.This medication is best used to cater to patients presenting with Parkinson-
like symptoms of Lewy body Dementia
24.When a patient has Memory loss that improves with cues, they are more
likely to have Dementia or Pseudodementia? - ANSWER Pseudodementia
25.When a patient is completing a Cognitive Test and they try hard but still
perform poorly, they are more likely to have Dementia or Pseudodementia? -
ANSWER Dementia
26.When recalling history a patient with Dementia/Pseudodementia will give a
detailed history and a patient with Dementia/Pseudodementia will give a
vague history with few details. The - ANSWER Pseudodementia
Dementia
27.Pseudodementia (depression) has a gradual progression, True or False? -
ANSWER False, Rapid Onset
Dementia has a gradual progression
28.Which of the following medications can be used for Delirium? SATA
A. Haloperidol
B. Levadopa
C. Diazepam
D. Diphenhydramine
E. Quetiapine - ANSWER A. Haloperidol