NBME CBSE ACTUAL TEST QUESTIONS &
ANSWERS COMPLETE QUIZ
BANK WITH CORRECT ANSWERS 2026/2027
LATEST MEDICAL EXAM UPDATE
VERIFIED & GUARANTEED PASS
4 year old from Brazil - PE shows single 12x10cm lesion in the right side of jaw with diffuse
regular edges. Photomicrographs of an incisional biopsy (looks like Burkitts Lymphoma/
Starry night) - which of the processes most likely to occur in the region indicated by the
arrow? -
Answer- Apoptosis
b. Endemic Burkitt lymphoma can happen in Brazil as well as Africa (jaw lesion, puffy face).
5 1 year old - lump on tongue - 1 pack smoking history for 30 years. 1.5 cm mass on apex of
tongue. It is most appropriate to evaluate which lymph nodes first for evidence of metastasis?
Answer- Submental
1 5 year old boy - ER - 2 hour history of confusion and agitation - fever, headache, stiff neck,
and vomiting - since returned from summer camp - patient is hallucinating - lumbar puncture
- shows cysts and trophozoites- most likely pathogen? -Answer- a. Olfactory Nerve Naegleria
fowleri
1 7 year old - ED - 30 minutes after being found with a blank stare. Physical exam shows
rigidity.
During exam he becomes hostile and assaults physician - Pt ingested which drug? -Answer-
PCP Placebo controlled clinical trial - 5000 pts with essential hypertension. 2500 patients
receive new drug and 2500 patients receive placebo. If alpha is set at 0.01 instead of 0.05,
which of the following is most likely result? -Answer- Significant findings can be reported
with greater confidence
Page 1 of 228
,1 7 year old - gymnast - comes to hospital because of lack of menstrual period for 6 months.
BMI 15 Which is the cause of the amenorrhea? -Answer- Hypogonadotropic Hypogonadism
A male stillborn is delivered at 32 weeks - Oligohydramnios - absence of a urethral opening.
Which is most likely finding? -Answer- Pulmonary Hypoplasia
A 6 day old - breast fed boy in ED - poor weight gain and irritability since delivery - Physical
exam shows jaundice and hepatomegaly. The concentration of which of the following
metabolites is most likely increased? -Answer- a. Galactose - 1 - phosphate b. Congenital
intolerance to breast milk
A 25-year-old man - comes to ED - severe muscle pain, diffuse, painful swelling of his neck,
underarms, and groin after camping in New Mexico Generalized scattered black maculae.
Examination of the right upper extremity shows erythematous, solid, tender mass. Mass is
draining blood and necrotic material. The most effective antibiotic for patient disorder will
interfere with which of the following processes? -Answer- a. Ribosomal Assembly b.
Yersenia Pestis
4 5 year old - progressive weakness - muscle fasciculations of the upper extremities and
weakness of the lower extremity - What additional findings? -Answer- Atrophy b. ALS =
Lou Gherig
A new severe respiratory illness - Why use a killed vaccine vs a live vaccine? -Answer-
Avoids Concerns of reversion to virulence
b. Killed vaccines - avoids reversion to virulence
c. live vaccines - can (but rarely do) cause the disease they're designed to prevent
A 33 year old - keratinizing squamous cell carcinoma of cervix. Which of the following
describes pathogenesis of this patient's disease? -Answer- Inactivation of Cellular P53 b. p53
protein = tumor suppressor (it activates apoptosis) - most human cancer
A 54 year old - 40 year history of T1DM - receiving hemodialysis for end stage renal disease
while awaiting a kidney transplant. Receives a drug that induces reticulocyte release from
bone
marrow and stimulates a cytokine receptor that signals Jak/Stat pathway? -Answer-
Erythropoietin
Page 2 of 228
,Jak Stat - erythropoietin
During a clinical study examining the effects of exercise. The average pulse is 175/min.
Compared with measurement before the session, which is most likely decreased? -
Answer- Total Peripheral Resistance
An 8-year-old boy - 3-day history of fever, sore throat, and itchy eyes. Returned from week
long summer camp that includes hiking trips and swimming - PE shows conjunctival
injection and oropharyngeal edema - Outbreak among other campers.
Which is most likely cause of this patient's symptoms? -Answer- Adenovirus Fever+ Sore
Throat + Itchy Eyes transmitted via swimming pools Conjunctivitis Viral = adenovirus
44 -year-old woman - 10 month history of wide red streaks over her lower trunk (striae) and
weight gain in face (moonface). Which additional findings? -Answer- Hypertension and
muscle weakness
b. Cushing - hypertension and muscle weakness
1 2 year old boy - pain below left knee -unable to play soccer - An x-ray shown - Which
structures attached to the abnormal anterior tibial area? -Answer- patellar ligament b.
Osgood-Schlatter
6 2 year old woman - osteoporosis - a bisphosphonate is prescribed. The expected beneficial
effect of the drug is due to which of the following? -Answer- Decreased Osteoclast Activity
Cohot Study of elderly women - relative risk ratio for hip fractures among those who exercise
regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the
conclusion about the effect of exercise on the risk of hip fracture? -Answer-
Statistically Significant Overall Increase Risk
5 2 year old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse
is 80/min and blood pressure is 130/70. The most immediate treatment mechanism of action?
-Answer- Increased nitric oxide concentration
Page 3 of 228
, 2 4 year old woman - spilled hot grease on her left leg while working at a fast-food
restaurant. Exam of leg shows 7cm pink, soft, granular, edematous wound. The formation of
this tissue was most likely caused by increased activity of which? -Answera. Vascular
Endothelial Growth Factor VEGF - stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels - early wound repair
2 7 year old man- MVC - skull x-ray shows a linear, nondepressed basal skull fracture
increased serum osm and decreased urin osm. Following desmopressin urine osm increases.
Desmopressin's effect is due to the activation of which of the following? - Answer- a.
Adenylyl Cyclase
Adenylate Cyclase - ATP - CAMP -- PROTEKINASE A -- Ca v2
A 10 month old boy - 4 day history of fever and cough. He attends day care center. Chest
exam shows intercostal retractions along with bilateral, diffuse wheezes and expiratory
rhonchi. The infectious agent most likely has which of the following properties? -
Answer- Mediation of Cell Entry via a fusion protein
A 17 year old girl in ED - 15 minutes after being stung by a bee. Mild light headedness but
no difficulty swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy
for this patient? -Answer- B2- Agonist
1 4 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1 week
of fatigue. He recentaly had sex with one partner. Physical exam show cervical
lymphadenopathy and pharyngeal erythema with a creamy exudate. DX?
-Answer- Infectious Mononucleosis
5 7 year old man - radiation therapy for squamous cell carcinoma of the lung. Despite
therapy, tumor increases in size and he dies 6 months later. The progressive tumor growth is
due to a defect in cell cycle arrest in which of the following phases of cell cycle? -Answer-
G1
2 8 year old - lived in sub-Saharan Africa - until he came to the US. Temp of 100.4 - imaging
shows bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered
granulomas. DX? -Answer- Schistosomiasis
Page 4 of 228
ANSWERS COMPLETE QUIZ
BANK WITH CORRECT ANSWERS 2026/2027
LATEST MEDICAL EXAM UPDATE
VERIFIED & GUARANTEED PASS
4 year old from Brazil - PE shows single 12x10cm lesion in the right side of jaw with diffuse
regular edges. Photomicrographs of an incisional biopsy (looks like Burkitts Lymphoma/
Starry night) - which of the processes most likely to occur in the region indicated by the
arrow? -
Answer- Apoptosis
b. Endemic Burkitt lymphoma can happen in Brazil as well as Africa (jaw lesion, puffy face).
5 1 year old - lump on tongue - 1 pack smoking history for 30 years. 1.5 cm mass on apex of
tongue. It is most appropriate to evaluate which lymph nodes first for evidence of metastasis?
Answer- Submental
1 5 year old boy - ER - 2 hour history of confusion and agitation - fever, headache, stiff neck,
and vomiting - since returned from summer camp - patient is hallucinating - lumbar puncture
- shows cysts and trophozoites- most likely pathogen? -Answer- a. Olfactory Nerve Naegleria
fowleri
1 7 year old - ED - 30 minutes after being found with a blank stare. Physical exam shows
rigidity.
During exam he becomes hostile and assaults physician - Pt ingested which drug? -Answer-
PCP Placebo controlled clinical trial - 5000 pts with essential hypertension. 2500 patients
receive new drug and 2500 patients receive placebo. If alpha is set at 0.01 instead of 0.05,
which of the following is most likely result? -Answer- Significant findings can be reported
with greater confidence
Page 1 of 228
,1 7 year old - gymnast - comes to hospital because of lack of menstrual period for 6 months.
BMI 15 Which is the cause of the amenorrhea? -Answer- Hypogonadotropic Hypogonadism
A male stillborn is delivered at 32 weeks - Oligohydramnios - absence of a urethral opening.
Which is most likely finding? -Answer- Pulmonary Hypoplasia
A 6 day old - breast fed boy in ED - poor weight gain and irritability since delivery - Physical
exam shows jaundice and hepatomegaly. The concentration of which of the following
metabolites is most likely increased? -Answer- a. Galactose - 1 - phosphate b. Congenital
intolerance to breast milk
A 25-year-old man - comes to ED - severe muscle pain, diffuse, painful swelling of his neck,
underarms, and groin after camping in New Mexico Generalized scattered black maculae.
Examination of the right upper extremity shows erythematous, solid, tender mass. Mass is
draining blood and necrotic material. The most effective antibiotic for patient disorder will
interfere with which of the following processes? -Answer- a. Ribosomal Assembly b.
Yersenia Pestis
4 5 year old - progressive weakness - muscle fasciculations of the upper extremities and
weakness of the lower extremity - What additional findings? -Answer- Atrophy b. ALS =
Lou Gherig
A new severe respiratory illness - Why use a killed vaccine vs a live vaccine? -Answer-
Avoids Concerns of reversion to virulence
b. Killed vaccines - avoids reversion to virulence
c. live vaccines - can (but rarely do) cause the disease they're designed to prevent
A 33 year old - keratinizing squamous cell carcinoma of cervix. Which of the following
describes pathogenesis of this patient's disease? -Answer- Inactivation of Cellular P53 b. p53
protein = tumor suppressor (it activates apoptosis) - most human cancer
A 54 year old - 40 year history of T1DM - receiving hemodialysis for end stage renal disease
while awaiting a kidney transplant. Receives a drug that induces reticulocyte release from
bone
marrow and stimulates a cytokine receptor that signals Jak/Stat pathway? -Answer-
Erythropoietin
Page 2 of 228
,Jak Stat - erythropoietin
During a clinical study examining the effects of exercise. The average pulse is 175/min.
Compared with measurement before the session, which is most likely decreased? -
Answer- Total Peripheral Resistance
An 8-year-old boy - 3-day history of fever, sore throat, and itchy eyes. Returned from week
long summer camp that includes hiking trips and swimming - PE shows conjunctival
injection and oropharyngeal edema - Outbreak among other campers.
Which is most likely cause of this patient's symptoms? -Answer- Adenovirus Fever+ Sore
Throat + Itchy Eyes transmitted via swimming pools Conjunctivitis Viral = adenovirus
44 -year-old woman - 10 month history of wide red streaks over her lower trunk (striae) and
weight gain in face (moonface). Which additional findings? -Answer- Hypertension and
muscle weakness
b. Cushing - hypertension and muscle weakness
1 2 year old boy - pain below left knee -unable to play soccer - An x-ray shown - Which
structures attached to the abnormal anterior tibial area? -Answer- patellar ligament b.
Osgood-Schlatter
6 2 year old woman - osteoporosis - a bisphosphonate is prescribed. The expected beneficial
effect of the drug is due to which of the following? -Answer- Decreased Osteoclast Activity
Cohot Study of elderly women - relative risk ratio for hip fractures among those who exercise
regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the
conclusion about the effect of exercise on the risk of hip fracture? -Answer-
Statistically Significant Overall Increase Risk
5 2 year old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse
is 80/min and blood pressure is 130/70. The most immediate treatment mechanism of action?
-Answer- Increased nitric oxide concentration
Page 3 of 228
, 2 4 year old woman - spilled hot grease on her left leg while working at a fast-food
restaurant. Exam of leg shows 7cm pink, soft, granular, edematous wound. The formation of
this tissue was most likely caused by increased activity of which? -Answera. Vascular
Endothelial Growth Factor VEGF - stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels - early wound repair
2 7 year old man- MVC - skull x-ray shows a linear, nondepressed basal skull fracture
increased serum osm and decreased urin osm. Following desmopressin urine osm increases.
Desmopressin's effect is due to the activation of which of the following? - Answer- a.
Adenylyl Cyclase
Adenylate Cyclase - ATP - CAMP -- PROTEKINASE A -- Ca v2
A 10 month old boy - 4 day history of fever and cough. He attends day care center. Chest
exam shows intercostal retractions along with bilateral, diffuse wheezes and expiratory
rhonchi. The infectious agent most likely has which of the following properties? -
Answer- Mediation of Cell Entry via a fusion protein
A 17 year old girl in ED - 15 minutes after being stung by a bee. Mild light headedness but
no difficulty swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy
for this patient? -Answer- B2- Agonist
1 4 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1 week
of fatigue. He recentaly had sex with one partner. Physical exam show cervical
lymphadenopathy and pharyngeal erythema with a creamy exudate. DX?
-Answer- Infectious Mononucleosis
5 7 year old man - radiation therapy for squamous cell carcinoma of the lung. Despite
therapy, tumor increases in size and he dies 6 months later. The progressive tumor growth is
due to a defect in cell cycle arrest in which of the following phases of cell cycle? -Answer-
G1
2 8 year old - lived in sub-Saharan Africa - until he came to the US. Temp of 100.4 - imaging
shows bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered
granulomas. DX? -Answer- Schistosomiasis
Page 4 of 228
