Hematology USMLE step 1 Exam Questions with
Answers
1. What transporter is found on Erythrocytes and what is the function?
correct answer HCO3-/Cl- antiporter
HCO3- leaves the RBC and Cl- moves into RBC (chloride shift)
2. Source of energy for RBC and how is it used? correct answer GLUCOSE
-90% in glycolysis
-10% in HMP shunt
3. Platelets
a. Life span
b. Function
c. Where are they stored? correct answer a. 8-10 days
b. Primary hemostasis (forms platelet plug by aggregating and sticking to fibrinogen)
c. Spleen (1/3 of them are there)
4. Granules of Platelets contain correct answer Dense granules correct answer ADP,
Ca+2. TXA2
alpha granules correct answer vWF, Fibrinogen
5. Thrombopoietin
a. Made where?
b. Function correct answer a. Liver and kidney
b. Causes megakaryocytes to proliferate/ditterentiate and make platelets
6. vWF receptor on platelet correct answer Gp Ib
7. Fibrinogen receptor on platelet correct answer Gp IIb/IIIa
8. Thrombocytopenia results in . correct
answer Petechiae
9. Neutrophilic specific granules contain what? correct answer ALP
(alkaline phosphatase) Lysozyme
Collagenase
,Lactoferrin
10. Neutrophilic Lysosomes contain what?
correct answer Myeloperoxidase Beta-glucuronidase
Acid phosphatase
Proteinases
,11. Neutrophilic chemotactic
agents correct answer C5a LTB4
(leukotriene)
IL-8
Platelet-activating Factor (PAF)
Kalikrein
12. Band Cells have decreased receptors.
correct answer Fc receptors (CD16)
13. Hyper segmented PMNs are
seen in . correct answer B12/Folate deficiency
14. Increased band cells are seen in
. correct answer Myeloid proliferation
15. Causes of neutrophilia correct answer - Leukocyte adhesion deficiency
-Corticosteroid use
-Acute bacterial infections
-Tissue necrosis
16. Agranulocytosis
a. What is it?
b. Etiology
c. S/S correct answer a. Extremely low neutrophil count (near absent) w/ normal Hb and platelet count
b. (Agranulocytosis Certainly Causes Pretty Major Collapse To Defense Cells)
-Clozapine
-Colchicine
-Propythiouracil
-Methimazole
-Chloramphenicol
-Ticlopidine
-Dapsone
-Carbamazepine
c.
, -Necrotizing ulcers in mouth and throat
-Increased risk of life-threatening infections
Answers
1. What transporter is found on Erythrocytes and what is the function?
correct answer HCO3-/Cl- antiporter
HCO3- leaves the RBC and Cl- moves into RBC (chloride shift)
2. Source of energy for RBC and how is it used? correct answer GLUCOSE
-90% in glycolysis
-10% in HMP shunt
3. Platelets
a. Life span
b. Function
c. Where are they stored? correct answer a. 8-10 days
b. Primary hemostasis (forms platelet plug by aggregating and sticking to fibrinogen)
c. Spleen (1/3 of them are there)
4. Granules of Platelets contain correct answer Dense granules correct answer ADP,
Ca+2. TXA2
alpha granules correct answer vWF, Fibrinogen
5. Thrombopoietin
a. Made where?
b. Function correct answer a. Liver and kidney
b. Causes megakaryocytes to proliferate/ditterentiate and make platelets
6. vWF receptor on platelet correct answer Gp Ib
7. Fibrinogen receptor on platelet correct answer Gp IIb/IIIa
8. Thrombocytopenia results in . correct
answer Petechiae
9. Neutrophilic specific granules contain what? correct answer ALP
(alkaline phosphatase) Lysozyme
Collagenase
,Lactoferrin
10. Neutrophilic Lysosomes contain what?
correct answer Myeloperoxidase Beta-glucuronidase
Acid phosphatase
Proteinases
,11. Neutrophilic chemotactic
agents correct answer C5a LTB4
(leukotriene)
IL-8
Platelet-activating Factor (PAF)
Kalikrein
12. Band Cells have decreased receptors.
correct answer Fc receptors (CD16)
13. Hyper segmented PMNs are
seen in . correct answer B12/Folate deficiency
14. Increased band cells are seen in
. correct answer Myeloid proliferation
15. Causes of neutrophilia correct answer - Leukocyte adhesion deficiency
-Corticosteroid use
-Acute bacterial infections
-Tissue necrosis
16. Agranulocytosis
a. What is it?
b. Etiology
c. S/S correct answer a. Extremely low neutrophil count (near absent) w/ normal Hb and platelet count
b. (Agranulocytosis Certainly Causes Pretty Major Collapse To Defense Cells)
-Clozapine
-Colchicine
-Propythiouracil
-Methimazole
-Chloramphenicol
-Ticlopidine
-Dapsone
-Carbamazepine
c.
, -Necrotizing ulcers in mouth and throat
-Increased risk of life-threatening infections
