NUR 2407 Exam 1 Practice Questions and Correct Answers with
Explanation | Latest Update | Rasmussen University
1. Which phase of pharmacokinetics is most affected by the ‘first-pass effect’?
A. Distribution
B. Absorption
C. Excretion
D. Metabolism
Answer: D
Explanation: The first-pass effect refers to the metabolism of a drug by the liver before it
reaches the systemic circulation, significantly reducing the concentration of the active drug.
2. A drug has a half-life of 4 hours. If a dose of 400 mg is given at 12:00 PM, how
much drug will remain in the patient’s system at 8:00 PM?
A. 200 mg
B. 50 mg
C. 100 mg
D. 25 mg
Answer: C
Explanation: After one half-life (4 hours), 200 mg remains. After two half-lives (8 hours),
100 mg remains.
,3. Which term describes a drug that binds to a receptor and produces a maximal
response?
A. Antagonist
B. Inverse Agonist
C. Partial Agonist
D. Agonist
Answer: D
Explanation: An agonist is a drug that binds to a receptor and mimics the body’s natural
response to produce a therapeutic effect.
4. During which step of the nursing process does the nurse collect subjective
and objective data regarding a patient’s medication history?
A. Planning
B. Assessment
C. Evaluation
D. Implementation
Answer: B
Explanation: Assessment is the first step of the nursing process, involving the collection of
all relevant data to identify patient needs.
,5. To ensure patient safety, how many patient identifiers should a nurse use
before administering medication?
A. Two
B. One
C. Three
D. Four
Answer: A
Explanation: The Joint Commission requires at least two patient identifiers (e.g., name and
date of birth) to ensure the right patient receives the medication.
6. Which route of administration provides 100% bioavailability?
A. Intravenous (IV)
B. Subcutaneous (SQ)
C. Oral (PO)
D. Intramuscular (IM)
Answer: A
Explanation: Intravenous administration bypasses the GI tract and first-pass metabolism,
allowing the entire dose to enter the bloodstream immediately.
, 7. A patient with low serum albumin levels is at risk for which drug-related
complication?
A. Decreased drug excretion
B. Reduced drug absorption
C. Drug toxicity
D. Increased first-pass effect
Answer: C
Explanation: Albumin is a protein that binds drugs. If albumin is low, there is more free
(active) drug in the blood, which can lead to toxicity.
8. Which organ is primarily responsible for the excretion of medications from
the body?
A. Lungs
B. Skin
C. Liver
D. Kidneys
Answer: D
Explanation: While other organs contribute, the kidneys are the primary site for drug
excretion through urine.
Explanation | Latest Update | Rasmussen University
1. Which phase of pharmacokinetics is most affected by the ‘first-pass effect’?
A. Distribution
B. Absorption
C. Excretion
D. Metabolism
Answer: D
Explanation: The first-pass effect refers to the metabolism of a drug by the liver before it
reaches the systemic circulation, significantly reducing the concentration of the active drug.
2. A drug has a half-life of 4 hours. If a dose of 400 mg is given at 12:00 PM, how
much drug will remain in the patient’s system at 8:00 PM?
A. 200 mg
B. 50 mg
C. 100 mg
D. 25 mg
Answer: C
Explanation: After one half-life (4 hours), 200 mg remains. After two half-lives (8 hours),
100 mg remains.
,3. Which term describes a drug that binds to a receptor and produces a maximal
response?
A. Antagonist
B. Inverse Agonist
C. Partial Agonist
D. Agonist
Answer: D
Explanation: An agonist is a drug that binds to a receptor and mimics the body’s natural
response to produce a therapeutic effect.
4. During which step of the nursing process does the nurse collect subjective
and objective data regarding a patient’s medication history?
A. Planning
B. Assessment
C. Evaluation
D. Implementation
Answer: B
Explanation: Assessment is the first step of the nursing process, involving the collection of
all relevant data to identify patient needs.
,5. To ensure patient safety, how many patient identifiers should a nurse use
before administering medication?
A. Two
B. One
C. Three
D. Four
Answer: A
Explanation: The Joint Commission requires at least two patient identifiers (e.g., name and
date of birth) to ensure the right patient receives the medication.
6. Which route of administration provides 100% bioavailability?
A. Intravenous (IV)
B. Subcutaneous (SQ)
C. Oral (PO)
D. Intramuscular (IM)
Answer: A
Explanation: Intravenous administration bypasses the GI tract and first-pass metabolism,
allowing the entire dose to enter the bloodstream immediately.
, 7. A patient with low serum albumin levels is at risk for which drug-related
complication?
A. Decreased drug excretion
B. Reduced drug absorption
C. Drug toxicity
D. Increased first-pass effect
Answer: C
Explanation: Albumin is a protein that binds drugs. If albumin is low, there is more free
(active) drug in the blood, which can lead to toxicity.
8. Which organ is primarily responsible for the excretion of medications from
the body?
A. Lungs
B. Skin
C. Liver
D. Kidneys
Answer: D
Explanation: While other organs contribute, the kidneys are the primary site for drug
excretion through urine.
