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7B - Substance-related disorders

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with pictures! 7B - Substance-related disorders *Mini-lecture 1 : Psychoactive substances - Liking vs. wanting "Liking" vs. "wanting": example • Motivational value:  Substance use: • The distinction ... o Initial liking may... o Build tolerance and... • Over the course of their addiction, an individual may experience: o o o o *Mini-lecture 2 : Clinical description of substance-related disorders Substance-related disorders • "A problematic pattern of manifested by at least two… symptoms within a 12-month period." o Polysubstance • o Impaired (1) Use ... (2) Unsuccessful... (3) Spend a... (4) Cr... o blank impairment symptoms: (5) Failure to (6) Continue (7) Give o Risky use symptoms: (8) Re o blank symptoms : (10) ; (11) . • o Severity: Mild, Moderate, or severe, based on number of symptoms present *Mini-lecture 3 : Biological factors in substance-related disorders Substance-related disorders: Genetic factors • Evidence suggests that o Heritability ... o Inherited o Susceptibility to s Substance-related disorders: Neurobiology • All abused substances affect o "Liking" = blank in brain • Dissociable to "wanting" pathway o "Wanting" =blank ... system • High density of • Repeated exposure leads to o VTA = *Mini-lecture 4 : Psychological factors in substance-related disorders Psychological factors: Reinforcement • ... influences: o Cultural differences in s... o Expectancy effects ... • Experience will be influenced by ... • Placebo effect • Can also predict ... o Parental monitoring and behavior • Positive reinforcement... o Psychoactive substances create... o ... • ... • Negative reinforcement o Substance use may ... o ... *Mini-lecture 5 : The conditioned compensatory response Drug use: Our body's compensatory response • Our bodies work to ... o To counteract the effects of ... our bodies produce ... ... Recall: Classical conditioning • ... • Our conditioned response (CR) ... US Classical condition and drug use • ... • CS - • CR - • US - Conditioned compensatory response • ... o Contributes to drug tolerance:... o May make it harder ... o Can contribute to ... • New environment - No cues (CS) - no "preparation" via CCR - stronger effect of drug - increased risk of overdose

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7B - Substance-related disorders
Thursday, March 4, 2021
7:43 AM
*Mini-lecture 1 : Psychoactive substances - Liking vs. wanting
"Liking" vs. "wanting": An example
 Consider the distinction between "wanting" and "liking":
o "Liking" food
 Feelings of enjoyment; bliss; pleasure…
 Hedonic value: how much we cognitively "like" something
 Subjective "goodness"
o "Wanting" food
 Excitement; agitation; maybe even aggression
 Motivational value: how much we "want" something
 Incentive salience and reward

Substance use: "Liking" a drug
 The distinction is helpful in understanding the maintenance of substance use disorders:
o Initial liking may help initiate substance use, but over the course of
addiction the person may come to want the drug more than they like it
o Build tolerance and need more to get the same effect / pleasure
 Over the course of their addiction, an individual may experience:
o Narrowing behavioral repertoire
o Craving, preoccupation, reduced control over use
o Increased tolerance and withdrawal
o Low self-esteem, denial, rationalization, conflicts over dependency…




*Mini-lecture 2 : Clinical description of substance-related disorders
Substance-related disorders
 "A problematic pattern of [________ substance} use leading to clinically significant distress
or impairment, as manifested by at least two… symptoms within a 12-month period."
o Polysubstance (many substances at once) use is common!!
 Substance-related Disorder (opioids)

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10 april 2021
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Erin sparks
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