(IGNS) IG CERTIFIED
PHARMACIST (IGCP)
CREDENTIAL EXAM
What are the treatment options for pemphigus/pemphigoid?
1) immunosuppressants
2) cytotoxic drugs
3) IVIG
4) rituxan
5) gold compounds
6) dapsone
Which type of ITP occurs after a viral infection?
Acute ITP
T/F: In ITP, red and white blood cells are normal, but the platelet
count is low.
True
What laboratory test confirms the diagnosis of ITP?
Bone marrrow testing
What is the first line treatment for ITP?
Corticosteroids as they help increase platelet count
List 3 other treatments for ITP
Rituxan®(rituximab)
IVIG
Anti-Rh (D) Ig
,Splenectomy
Promacta®(eltrombopag) or Nplate® (romiplostim)
What is the MOA of chronic lymphocytic leukemia (CLL)?
In CLL, abnormally high numbers of ineffective lymphocytes are
found in the blood and or bone marrow and collect in the lymph
nodes, liver, and spleen. These high numbers of lymphocytes interfere
with the proper production of red blood cells and platelets.
Which of the following is not characteristic of CLL?
a. Anemia and/or low platelets
b. Weakness, night sweats, weight loss, painful lymph node
swelling, fever
c. Auto-immune hemolytic anemia
d. Rapidly enlarging lymph nodes, spleen, or liver
e. Repeated infections
f. none
All are characteristic
What lab testings can confirm the dx of CLL?
Lab testing for proteins such as ZAP-70 and CD38 can confirm the
diagnosis
What is the treatment if a person is dx with asymptomatic with
CLL?
Blood work and physical q 3 months
Advanced or symptomatic CLL is generally treated first with
Chemotherapy that contains one or more agents
For relapsing or refractory disease what are the treatment options
removal of the spleen or a bone marrow transplant may be considered
,autologous bone marrow transplant
the patient receives his own bone marrow cells which have been
harvested, cleansed, treated, and then stored before the remaining
bone marrow is destroyed
allogenic bone marrow transplant
a transplant in which the recipient receives bone marrow from a
compatible donor
Which of the following is NOT associated with chronic GVHD?
1. Dry eyes or vision changes
2. Abdominal pain, N/V/D
3. Dry mouth, white patches inside the mouth, and sensitivity to
spicy foods
4. Fatigue, muscle weakness, and chronic pain
5. Joint pain or stiffness
6. Jaundice
7.Skin rash with raised, discolored areas, as well as skin
tightening or thickening
8. Shortness of breath
9. Vaginal dryness
10. Weight loss
2. & 6 are associated with acute GVHD
What are the three tests performed to evaluate transplant
donors?
blood type, crossmatch, and HLA testing.
Blood from the donor and recipient are mixed to see if transplant
recipient cells and donor cells are considered compatible
crossmatching
, What are some reasons Anti-HLA antibodies can become
sensitized?
Pregnancy (3 or more)
Blood transfusions
Vaccinations
Previous transplant
Previous infections and surgeries
List the 4 steps of Anti-HLA antibodies sensitization
1. Exposure to an antigen (virus, bacteria, transplanted tissue) is
identified as non-self because the protein identifier on the foreign
material does not match the self.
2. B cells are activated, which results in plasma cells.
3. These plasma cells release anti-HLA antibodies that mark and
attack the non-self antigen.
4. Before the antigen is removed, memory B cells develop and can
quickly identify the antigen on subsequent exposure.
This blood test is used to measure the number of anti-HLA
antibodies of the transplant recipient and is expressed as a
percentage, it has a range of 0 - 99.
Panel Reactive Antibody (PRA)
A calculation of the reaction frequency of unacceptable HLA
antigens to which the patient has been sensitized is performed
Calculated PRA
A blood test used to screen for antibodies in the transplant
recipient that are directed against the donor's HLA antigens
Donor Specific Antibody (DSA)
PHARMACIST (IGCP)
CREDENTIAL EXAM
What are the treatment options for pemphigus/pemphigoid?
1) immunosuppressants
2) cytotoxic drugs
3) IVIG
4) rituxan
5) gold compounds
6) dapsone
Which type of ITP occurs after a viral infection?
Acute ITP
T/F: In ITP, red and white blood cells are normal, but the platelet
count is low.
True
What laboratory test confirms the diagnosis of ITP?
Bone marrrow testing
What is the first line treatment for ITP?
Corticosteroids as they help increase platelet count
List 3 other treatments for ITP
Rituxan®(rituximab)
IVIG
Anti-Rh (D) Ig
,Splenectomy
Promacta®(eltrombopag) or Nplate® (romiplostim)
What is the MOA of chronic lymphocytic leukemia (CLL)?
In CLL, abnormally high numbers of ineffective lymphocytes are
found in the blood and or bone marrow and collect in the lymph
nodes, liver, and spleen. These high numbers of lymphocytes interfere
with the proper production of red blood cells and platelets.
Which of the following is not characteristic of CLL?
a. Anemia and/or low platelets
b. Weakness, night sweats, weight loss, painful lymph node
swelling, fever
c. Auto-immune hemolytic anemia
d. Rapidly enlarging lymph nodes, spleen, or liver
e. Repeated infections
f. none
All are characteristic
What lab testings can confirm the dx of CLL?
Lab testing for proteins such as ZAP-70 and CD38 can confirm the
diagnosis
What is the treatment if a person is dx with asymptomatic with
CLL?
Blood work and physical q 3 months
Advanced or symptomatic CLL is generally treated first with
Chemotherapy that contains one or more agents
For relapsing or refractory disease what are the treatment options
removal of the spleen or a bone marrow transplant may be considered
,autologous bone marrow transplant
the patient receives his own bone marrow cells which have been
harvested, cleansed, treated, and then stored before the remaining
bone marrow is destroyed
allogenic bone marrow transplant
a transplant in which the recipient receives bone marrow from a
compatible donor
Which of the following is NOT associated with chronic GVHD?
1. Dry eyes or vision changes
2. Abdominal pain, N/V/D
3. Dry mouth, white patches inside the mouth, and sensitivity to
spicy foods
4. Fatigue, muscle weakness, and chronic pain
5. Joint pain or stiffness
6. Jaundice
7.Skin rash with raised, discolored areas, as well as skin
tightening or thickening
8. Shortness of breath
9. Vaginal dryness
10. Weight loss
2. & 6 are associated with acute GVHD
What are the three tests performed to evaluate transplant
donors?
blood type, crossmatch, and HLA testing.
Blood from the donor and recipient are mixed to see if transplant
recipient cells and donor cells are considered compatible
crossmatching
, What are some reasons Anti-HLA antibodies can become
sensitized?
Pregnancy (3 or more)
Blood transfusions
Vaccinations
Previous transplant
Previous infections and surgeries
List the 4 steps of Anti-HLA antibodies sensitization
1. Exposure to an antigen (virus, bacteria, transplanted tissue) is
identified as non-self because the protein identifier on the foreign
material does not match the self.
2. B cells are activated, which results in plasma cells.
3. These plasma cells release anti-HLA antibodies that mark and
attack the non-self antigen.
4. Before the antigen is removed, memory B cells develop and can
quickly identify the antigen on subsequent exposure.
This blood test is used to measure the number of anti-HLA
antibodies of the transplant recipient and is expressed as a
percentage, it has a range of 0 - 99.
Panel Reactive Antibody (PRA)
A calculation of the reaction frequency of unacceptable HLA
antigens to which the patient has been sensitized is performed
Calculated PRA
A blood test used to screen for antibodies in the transplant
recipient that are directed against the donor's HLA antigens
Donor Specific Antibody (DSA)
