UNE CHEM 1005 UNIT 3 COMPREHENSIVE
REVIEW 2026 QUESTIONS WITH
ANSWERS GRADED A+
>> An 11-year-old female is brought to the emergency department by her parent.
They report she has recently been very thirsty and needs to make frequent trips to
the bathroom. Physical examination revealed a thin girl in the 30th percentile for
height and weight. A rapid dipstick test revealed glucose in her urine. Evaluation
of this girl's blood would reveal decreased levels of which of the following
compounds or hormones?
Fatty acids
Glutamine
Glucose
Ketones
Insulin
Answer: Insulin
>> Which of the following enzymes used for ketone oxidation is not found in
liver cells?
HMG-CoA synthase
Thiophorase (succinyl-CoA:acetoacetate transferase)
Thiolase (acetyl-CoA C-acetyltransferase)
β-hydroxybutyrate dehydrogenase
Answer: Thiophorase (succinyl-CoA:acetoacetate transferase)
>> During the fasted state, lipolysis is facilitated by the action of
hormone-sensitive lipase. This enzyme requires which of the following
modifications for activation?
Allosteric activator
Phosphorylation
Cleavage
Dephosphorylation
, Glycosylation
Answer: Phosphorylation
>> A 3 day-old male is brought to the emergency department by ambulance. He
is unconscious on admission. Laboratory analysis of a blood sample shows
hypoglycemia and no ketones. Blood spot analysis showed elevation of medium
chain acylcarnitines as hexanoyl carnitine (C6), octanoyl carnitine (C8). A urine
sample was positive for dicarboxylic acids. This clinical picture is most
consistent with a defect in the:
ω-oxidation of short chain fatty acids
Carnitine transporter for long chain fatty acids
β-oxidation of medium chain fatty acids
α-oxidation of very long chain fatty acids
Answer: β-oxidation of medium chain fatty acids
>> Short-chain fatty acids and medium-chain fatty acids enter mitochondria by:
The malate-aspartate shuttle
Diffusion
Carnitine acyl-transferase mediated transporter
GLUT
Answer: Diffusion
>> Which of the following statements describes the role of HDL particles?
HDLs carry dietary fats and cholesterol from the intestine to the liver
HDLs transport cholesterol from peripheral tissues back to the liver
HDLs are taken up by peripheral tissues using the LDL receptor
HLDs carry triacylglycerols from the liver to the adipose for storage
Answer: HDLs transport cholesterol from peripheral tissues back to the
liver
>> Under cellular conditions when cholesterol is low, which of the following is a
true statement regarding the sterol response element-binding protein?
It will be bound to a plasma membrane receptor
REVIEW 2026 QUESTIONS WITH
ANSWERS GRADED A+
>> An 11-year-old female is brought to the emergency department by her parent.
They report she has recently been very thirsty and needs to make frequent trips to
the bathroom. Physical examination revealed a thin girl in the 30th percentile for
height and weight. A rapid dipstick test revealed glucose in her urine. Evaluation
of this girl's blood would reveal decreased levels of which of the following
compounds or hormones?
Fatty acids
Glutamine
Glucose
Ketones
Insulin
Answer: Insulin
>> Which of the following enzymes used for ketone oxidation is not found in
liver cells?
HMG-CoA synthase
Thiophorase (succinyl-CoA:acetoacetate transferase)
Thiolase (acetyl-CoA C-acetyltransferase)
β-hydroxybutyrate dehydrogenase
Answer: Thiophorase (succinyl-CoA:acetoacetate transferase)
>> During the fasted state, lipolysis is facilitated by the action of
hormone-sensitive lipase. This enzyme requires which of the following
modifications for activation?
Allosteric activator
Phosphorylation
Cleavage
Dephosphorylation
, Glycosylation
Answer: Phosphorylation
>> A 3 day-old male is brought to the emergency department by ambulance. He
is unconscious on admission. Laboratory analysis of a blood sample shows
hypoglycemia and no ketones. Blood spot analysis showed elevation of medium
chain acylcarnitines as hexanoyl carnitine (C6), octanoyl carnitine (C8). A urine
sample was positive for dicarboxylic acids. This clinical picture is most
consistent with a defect in the:
ω-oxidation of short chain fatty acids
Carnitine transporter for long chain fatty acids
β-oxidation of medium chain fatty acids
α-oxidation of very long chain fatty acids
Answer: β-oxidation of medium chain fatty acids
>> Short-chain fatty acids and medium-chain fatty acids enter mitochondria by:
The malate-aspartate shuttle
Diffusion
Carnitine acyl-transferase mediated transporter
GLUT
Answer: Diffusion
>> Which of the following statements describes the role of HDL particles?
HDLs carry dietary fats and cholesterol from the intestine to the liver
HDLs transport cholesterol from peripheral tissues back to the liver
HDLs are taken up by peripheral tissues using the LDL receptor
HLDs carry triacylglycerols from the liver to the adipose for storage
Answer: HDLs transport cholesterol from peripheral tissues back to the
liver
>> Under cellular conditions when cholesterol is low, which of the following is a
true statement regarding the sterol response element-binding protein?
It will be bound to a plasma membrane receptor
