PHAR 230 Questions and Correct Answers/
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What is pharmacology?
Ans: the study of medicine/drugs
what is a drug?
Ans: any substance received by a biological system that is not
for nutritional purposes
What is pharmacokinetics?
Ans: what the body does to the drug
What is pharmacodynamics?
Ans: what the drug does to the body
what is pharmacogenomics?
Ans: the study of genetic factors that underlie variations in
drug responses
why do we use drugs?
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Ans: 1. To achieve a beneficial effect on an individual
2. To exert a toxic effect on an invading organism
what is the most common mechanisms of action?
Ans: mediated by receptors
what is a receptor
Ans: a proteins that is the target of drug actions, can be
extracellular or intracellular
what type of drugs attach to extracellular receptors?
Ans: water-soluble drugs
what type of drugs attach to intracellular receptors?
Ans: fat-soluble drugs
what are the forms of drug receptors?
Ans: R-regulatory proteins, E-enzymes, S-structural proteins,
T-transporters
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which site of a receptor can drugs bind to?
Ans: the active site or the allosteric site
what are the drugs that act on the active site called?
Ans: full agonists
partial agonists
antagonists
inverse agonists
drugs are coupled with...
Ans: intracellular receptors
ion channel receptors
g-protein coupled receptors
enzyme-linked receptors
dose
Ans: the measured quantity of a therapeutic agent to be taken
at one time
drug response
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Ans: the response on the body from a drug
dose-response relationship
Ans: the more drug given, the greater the response, to a
certain point
potency
Ans: the dose or concentration of a drug required to produce a
response of a certain magnitude
efficacy
Ans: the maximal response that a drug can produce as we
increase the dose in that system
which is clinically favoured: potency or efficacy?
Ans: efficacy
therapeutic index
Ans: Quantitative measurement of the relative safety of a
drug, compares the amount of drug that causes therapeutic
effect to the amount that causes toxicity
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