Module 2 MSN 672 Test Questions and
All Correct Answers.
A 48-year-old patient with depression was recently started on 20 mg/day fluoxetine to combat
his presenting symptoms of apathy, fatigue, problems concentrating and hypersomnia. The
patient reports that he is feeling much more energized and can see improvements in his
cognition and attention within a day or two of starting fluoxetine. which of the following
properties of fluoxetine is theoretically most likely responsible for this patient's positive
response?
A. 5HT2C antagonism
B. Norepinephrine reuptake inhibition
C. Serotonin reuptake inhibition - Answer A 5HT2C antagonism
A 40-year-old woman presents with a major depressive episode. She has previously been
treated with an SSRI and experienced bothersome sexual dysfunction. Her clinician is
considering prescribing vilazodone, which has what pharmacologic action that may mitigate the
risk of sexual dysfunction.
A. Norepinephrine reuptake inhibition
B. Serotonin 2A antagonism
C. Serotonin 1A partial agonism - Answer C. Serotonin 1A partial agonism
Agents that block reuptake of norepinephrine have what effect on dopamine in the prefrontal
cortex?
A. Increase its synaptic availability
B. Decrease its synaptic availability
C. No notable effect on dopamine - Answer A. Increase its synaptic availability
A 58-year-old patient with a history of depression is currently taking agomelatine, which has
what mechanism of action?
A. Binding to melatonin receptors in the suprachiasmatic nucleus
B. Binding to 5HT2C receptors
C. Both the above
D. Neither of the above.. - Answer C. Both of the above.
Which of the following is the most potent property of trazodone?
A. Serotonin reuptake inhibition
B. Serotonin 2C antagonism
All Correct Answers.
A 48-year-old patient with depression was recently started on 20 mg/day fluoxetine to combat
his presenting symptoms of apathy, fatigue, problems concentrating and hypersomnia. The
patient reports that he is feeling much more energized and can see improvements in his
cognition and attention within a day or two of starting fluoxetine. which of the following
properties of fluoxetine is theoretically most likely responsible for this patient's positive
response?
A. 5HT2C antagonism
B. Norepinephrine reuptake inhibition
C. Serotonin reuptake inhibition - Answer A 5HT2C antagonism
A 40-year-old woman presents with a major depressive episode. She has previously been
treated with an SSRI and experienced bothersome sexual dysfunction. Her clinician is
considering prescribing vilazodone, which has what pharmacologic action that may mitigate the
risk of sexual dysfunction.
A. Norepinephrine reuptake inhibition
B. Serotonin 2A antagonism
C. Serotonin 1A partial agonism - Answer C. Serotonin 1A partial agonism
Agents that block reuptake of norepinephrine have what effect on dopamine in the prefrontal
cortex?
A. Increase its synaptic availability
B. Decrease its synaptic availability
C. No notable effect on dopamine - Answer A. Increase its synaptic availability
A 58-year-old patient with a history of depression is currently taking agomelatine, which has
what mechanism of action?
A. Binding to melatonin receptors in the suprachiasmatic nucleus
B. Binding to 5HT2C receptors
C. Both the above
D. Neither of the above.. - Answer C. Both of the above.
Which of the following is the most potent property of trazodone?
A. Serotonin reuptake inhibition
B. Serotonin 2C antagonism
