PMHNP CERTIFICATION LATEST 2026 ACTUAL EXAM 300
QUESTIONS AND CORRECT DETAILED ANSWERS WITH
RATIONALES (VERIFIED ANSWERS) |ALREADY GRADED
A+
What were the 8 high yield side effects of Lithium? - ANSWER--hypothyroidism,
maculopapular rash, fine hand tremors, GI upset (diarrhea, vomiting, cramps,
anorexia), T-wave inversions, and Leukocytosis (increased WBC), Diabetes
insipidus (polyuria, polydipsia)
What mood stabilizer is used to tx seizure disorders, manic phase of bipolar and
prevent migraine headaches? - ANSWER--Valproate Acid (Depakote)
Spinal bifida and neural tube defects can be caused by which mood stabilizer? -
ANSWER--Valproate Acid (Depakote)
Most common MAOI's ? - ANSWER--selegiline, Marplan (isocarboxazid),
phenelzine, and tranylcypromine.
Monoamine oxidase inhibitors inhibit the activity of one or both monoamine
oxidase enzymes: monoamine oxidase A and monoamine oxidase B. They are best
known as effective antidepressants in the tx for? - ANSWER--Treatment-resistant
depression and atypical depression.
HTN Crisis occurs when MAOIs are taken in conjunction with? - ANSWER--
Tyramine (a dietary precursor to norepinephrine, Meperidine (Demerol contains
Meperidine), Simulants (Methylphenidate) and other sympathomimetics,
decongestants
,PMHNP CERTIFICATION LATEST 2026 ACTUAL EXAM
300 QUESTIONS AND CORRECT DETAILED ANSWERS
WITH RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED
A+
Symptoms of HTN crisis? - ANSWER--elevated BP, Sudden explosive-like headache
(usually in occipital region (back of head). Facial flushing, palpitations, pupils
dilate, diaphoresis, fever. TX dc offending agent (MAOI)
Lamotrigine (Lamictal) (anticonvulsant) has a black box warning for? symptoms? -
ANSWER--Stevens Johnson Syndrome (severe rash). Symptoms fever, prodromal
HA, arthralgia (joint stiffness)
Carbamazepine (Tegretol) high yield three black box warnings? Particularly in
what race? - ANSWER--Agranulocytosis (decreased WBC), aplastic anemia
(symptoms:pallor, fatigue, headache, fever, nosebleeds, bleeding gums, skin rash,
SOB). Three A's - Agranuloctosis/aplastic anemia/Asians
In addition, Steven-Johnson syndrome, particularly in Asians (screen for HLAB-
1602 allele before initiating therapy). HLA-B 1502 allele is highly associated with
carbamaepine-induced Stevens Johnson Syndrome.
Check pregnancy status (HCG) before starting a female patient on psychotropic
medication of what childbearing age range? - ANSWER--12-51 years of age
What dose of folic acid is recommended when planning or capable of becoming
pregnant? - ANSWER--0.4mg-0.8mg of folic acid daily is recommended
DC Tx of Carbamazepine (Tegretol) when absolute neutrophil count (ANC) is? -
ANSWER--<1000, because of neutropenia (increases risk of infection)
,PMHNP CERTIFICATION LATEST 2026 ACTUAL EXAM 300
QUESTIONS AND CORRECT DETAILED ANSWERS WITH
RATIONALES (VERIFIED ANSWERS) |ALREADY GRADED
A+
Clozapine (Clozaril) atypical anti-psychotic, risk of agranulocytosis. DC Clozaril
when WBC is between? - ANSWER--2000-3000 Risk of agranulocytosis (4500-
11000 normal WBC)
Neutropenia is monitored by ANC only, and not in conjunction with? - ANSWER--
WBC
How often should you monitor absolute neutrophil count (ANC) during Clozapine
(Clozaril) therapy? - ANSWER--During the first 6 months test weekly
Second 6 months every two weeks, then monthly if ANC is WNL thereafter.
Clozapine (Clozaril) can decrease risk of suicide in pts with? - ANSWER--
Schizophrenia
Norepinephrine-dopamine reuptake inhibitors (NDRI) target? Common NDRI -
ANSWER--norepinephrie and dopamine. Wellbutrin
Inducers define? - ANSWER--inducing CYP450 enzyme to metabolize drugs quicker
which decreases serum level of drugs which cause lower subtherapeutic drug
levels
Clozapine (Clozaril) is metabolized by - ANSWER--CYP1A2
CYP450 Inducers are? - ANSWER--BullShit CRAP GPS induces rage - Mnemonic
, PMHNP CERTIFICATION LATEST 2024 ACTUAL EXAM 300
QUESTIONS AND CORRECT DETAILED ANSWERS WITH
RATIONALES (VERIFIED ANSWERS) |ALREADY GRADED
A+
Increase CYP450 Activity - Drug Clearance Faster + Drugs have LESSER effect.
Barbituates
St. Johns Wart
Carbamazepine
Rifampin
Alcohol (Chronic use)
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas CIGARETTE SMOKING
Dopamine is produced where? - ANSWER--Substantia Nigra
Dopamine regulates? - ANSWER--regulates motor movement and is associated
with addition and psychosis
GABA is what type of neurotransmitter? - ANSWER--Calming, most abundant
inhibitory neurotransmitter in the brain
Inhibitors mnemonic? - ANSWER--SICK FACES.COM
Sodium Valproate
Isoniazid
QUESTIONS AND CORRECT DETAILED ANSWERS WITH
RATIONALES (VERIFIED ANSWERS) |ALREADY GRADED
A+
What were the 8 high yield side effects of Lithium? - ANSWER--hypothyroidism,
maculopapular rash, fine hand tremors, GI upset (diarrhea, vomiting, cramps,
anorexia), T-wave inversions, and Leukocytosis (increased WBC), Diabetes
insipidus (polyuria, polydipsia)
What mood stabilizer is used to tx seizure disorders, manic phase of bipolar and
prevent migraine headaches? - ANSWER--Valproate Acid (Depakote)
Spinal bifida and neural tube defects can be caused by which mood stabilizer? -
ANSWER--Valproate Acid (Depakote)
Most common MAOI's ? - ANSWER--selegiline, Marplan (isocarboxazid),
phenelzine, and tranylcypromine.
Monoamine oxidase inhibitors inhibit the activity of one or both monoamine
oxidase enzymes: monoamine oxidase A and monoamine oxidase B. They are best
known as effective antidepressants in the tx for? - ANSWER--Treatment-resistant
depression and atypical depression.
HTN Crisis occurs when MAOIs are taken in conjunction with? - ANSWER--
Tyramine (a dietary precursor to norepinephrine, Meperidine (Demerol contains
Meperidine), Simulants (Methylphenidate) and other sympathomimetics,
decongestants
,PMHNP CERTIFICATION LATEST 2026 ACTUAL EXAM
300 QUESTIONS AND CORRECT DETAILED ANSWERS
WITH RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED
A+
Symptoms of HTN crisis? - ANSWER--elevated BP, Sudden explosive-like headache
(usually in occipital region (back of head). Facial flushing, palpitations, pupils
dilate, diaphoresis, fever. TX dc offending agent (MAOI)
Lamotrigine (Lamictal) (anticonvulsant) has a black box warning for? symptoms? -
ANSWER--Stevens Johnson Syndrome (severe rash). Symptoms fever, prodromal
HA, arthralgia (joint stiffness)
Carbamazepine (Tegretol) high yield three black box warnings? Particularly in
what race? - ANSWER--Agranulocytosis (decreased WBC), aplastic anemia
(symptoms:pallor, fatigue, headache, fever, nosebleeds, bleeding gums, skin rash,
SOB). Three A's - Agranuloctosis/aplastic anemia/Asians
In addition, Steven-Johnson syndrome, particularly in Asians (screen for HLAB-
1602 allele before initiating therapy). HLA-B 1502 allele is highly associated with
carbamaepine-induced Stevens Johnson Syndrome.
Check pregnancy status (HCG) before starting a female patient on psychotropic
medication of what childbearing age range? - ANSWER--12-51 years of age
What dose of folic acid is recommended when planning or capable of becoming
pregnant? - ANSWER--0.4mg-0.8mg of folic acid daily is recommended
DC Tx of Carbamazepine (Tegretol) when absolute neutrophil count (ANC) is? -
ANSWER--<1000, because of neutropenia (increases risk of infection)
,PMHNP CERTIFICATION LATEST 2026 ACTUAL EXAM 300
QUESTIONS AND CORRECT DETAILED ANSWERS WITH
RATIONALES (VERIFIED ANSWERS) |ALREADY GRADED
A+
Clozapine (Clozaril) atypical anti-psychotic, risk of agranulocytosis. DC Clozaril
when WBC is between? - ANSWER--2000-3000 Risk of agranulocytosis (4500-
11000 normal WBC)
Neutropenia is monitored by ANC only, and not in conjunction with? - ANSWER--
WBC
How often should you monitor absolute neutrophil count (ANC) during Clozapine
(Clozaril) therapy? - ANSWER--During the first 6 months test weekly
Second 6 months every two weeks, then monthly if ANC is WNL thereafter.
Clozapine (Clozaril) can decrease risk of suicide in pts with? - ANSWER--
Schizophrenia
Norepinephrine-dopamine reuptake inhibitors (NDRI) target? Common NDRI -
ANSWER--norepinephrie and dopamine. Wellbutrin
Inducers define? - ANSWER--inducing CYP450 enzyme to metabolize drugs quicker
which decreases serum level of drugs which cause lower subtherapeutic drug
levels
Clozapine (Clozaril) is metabolized by - ANSWER--CYP1A2
CYP450 Inducers are? - ANSWER--BullShit CRAP GPS induces rage - Mnemonic
, PMHNP CERTIFICATION LATEST 2024 ACTUAL EXAM 300
QUESTIONS AND CORRECT DETAILED ANSWERS WITH
RATIONALES (VERIFIED ANSWERS) |ALREADY GRADED
A+
Increase CYP450 Activity - Drug Clearance Faster + Drugs have LESSER effect.
Barbituates
St. Johns Wart
Carbamazepine
Rifampin
Alcohol (Chronic use)
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas CIGARETTE SMOKING
Dopamine is produced where? - ANSWER--Substantia Nigra
Dopamine regulates? - ANSWER--regulates motor movement and is associated
with addition and psychosis
GABA is what type of neurotransmitter? - ANSWER--Calming, most abundant
inhibitory neurotransmitter in the brain
Inhibitors mnemonic? - ANSWER--SICK FACES.COM
Sodium Valproate
Isoniazid
