SCRIPT 2026 PRACTICE SOLUTIONS
GRADED A+
● What is the typical appearance of melasma lesions? Answer: Irregular
hyperpigmented macules (light brown → dark brown/blue-gray)
● What are common facial distributions of melasma? Answer: Malar,
centrofacial, mandibular
● What is the primary pathophysiologic trigger of melasma? Answer:
UV radiation → melanocyte proliferation & pigment deposition
● Which population is most commonly affected by melasma? Answer:
Reproductive-age women
● Why is melasma common in pregnancy? Answer: Estrogen &
progesterone stimulate melanocytes
● What are other risk factors for melasma? Answer: Darker skin type,
thyroid dysfunction, antiepileptics, cosmetics