CANC 380 - MODULE 4: TUMOUR INVASION AND
METASTASIS QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS) |ALREADY GRADED
A+||BRAND NEW
What is one of the distinguishing features of cancer? Ans✓✓✓If left
untreated, growing tumours will invade local tissues and may spread to
other sites
What is metastatic cancer? Ans✓✓✓Cancer that has spread from where
it started to another location in the body
TRUE or FALSE: metastasis represents a significant barrier to the cure
of cancer Ans✓✓✓TRUE
What are the primary goals of treatment of metastatic cancer? Ans✓✓✓•
control the growth of cancer
• relieve symptoms caused by it
• extend the life of the patient
Before metastasis can begin, it is hypothesized that primary tumour cells
must meet certain requirements, or prerequisites, including: Ans✓✓✓•
tumour-initiating capacity
• angiogenesis
• resistance to cell death
, For malignant cells to form secondary lesions at a distant site away from
the primary tumour, they must have the ability to do what?
Ans✓✓✓Replicate
Researchers hypothesize that what cells, sometimes referred to as cancer
stem cells, have the ability to form metastatic lesions?
Ans✓✓✓Tumour-initiating cells (TICs)
What are the two supports for tumour-initiating capacity? Ans✓✓✓1.
Only a small population of cells removed from secondary tumours in
breast and brain cancer could give rise to cells with all cellular
phenotypes of the primary tumour
2. Overexpression of transcriptional activators associated with self-
renewal abilities of normal stem cells in primary humour cells result in
aggressive metastatic cancer
In order for cells to travel to different organs, they need to gain access to
what? Ans✓✓✓The vasculature
TRUE or FALSE: it has been theorized that angiogenesis is required for
metastasis Ans✓✓✓TRUE
Most of the research connecting metastasis and angiogenesis has been
conducted on what type of angiogenesis? Ans✓✓✓VEGF-mediated
angiogenesis
METASTASIS QUESTIONS AND CORRECT DETAILED
ANSWERS (VERIFIED ANSWERS) |ALREADY GRADED
A+||BRAND NEW
What is one of the distinguishing features of cancer? Ans✓✓✓If left
untreated, growing tumours will invade local tissues and may spread to
other sites
What is metastatic cancer? Ans✓✓✓Cancer that has spread from where
it started to another location in the body
TRUE or FALSE: metastasis represents a significant barrier to the cure
of cancer Ans✓✓✓TRUE
What are the primary goals of treatment of metastatic cancer? Ans✓✓✓•
control the growth of cancer
• relieve symptoms caused by it
• extend the life of the patient
Before metastasis can begin, it is hypothesized that primary tumour cells
must meet certain requirements, or prerequisites, including: Ans✓✓✓•
tumour-initiating capacity
• angiogenesis
• resistance to cell death
, For malignant cells to form secondary lesions at a distant site away from
the primary tumour, they must have the ability to do what?
Ans✓✓✓Replicate
Researchers hypothesize that what cells, sometimes referred to as cancer
stem cells, have the ability to form metastatic lesions?
Ans✓✓✓Tumour-initiating cells (TICs)
What are the two supports for tumour-initiating capacity? Ans✓✓✓1.
Only a small population of cells removed from secondary tumours in
breast and brain cancer could give rise to cells with all cellular
phenotypes of the primary tumour
2. Overexpression of transcriptional activators associated with self-
renewal abilities of normal stem cells in primary humour cells result in
aggressive metastatic cancer
In order for cells to travel to different organs, they need to gain access to
what? Ans✓✓✓The vasculature
TRUE or FALSE: it has been theorized that angiogenesis is required for
metastasis Ans✓✓✓TRUE
Most of the research connecting metastasis and angiogenesis has been
conducted on what type of angiogenesis? Ans✓✓✓VEGF-mediated
angiogenesis
