Answers.
IOM - Answer Institute of Medicine
•the standards of guideline development include the involvement of a multidisciplinary panel
and a comprehensive, systematic review of the evidence.
-focused on closing gap between the concept of quality healthcare delivery and actual clinical
care
IMO 6 aims to improve healthcare delivery - Answer 1. Safety
2. Effectiveness
3. Patient-centeredness
4. Timelines
5. Efficiency
6. Equity
Clinical Guidelines - Answer improve health outcomes by promoting clinical practice based
on the best evidence
1.reduce unnecessary practice variations
2. reduce the use of low-quality or minimum-value interventions
3. increase the use of valuable interventions that are underutilized
4. target interventions to populations that would receive the most benefit
what is important to put in clinical guidelines - Answer peer reviewed information
good guideline "based on consistent and systematic judgement of the evidence, clear in its
recommendations and translatable into practice
are not meant to mandate!
best kind of clinical trial - Answer preferably large randomized controlled trials rather than
smaller case studies with limited applicability
study designs - Answer RCT (randomized controlled trials) - highest ranking of evidence
observational studies
ect
Pharmacokinetics (PK) - Answer "what the body does to the drug"