NR507 WEEK 5 EDAPT MOOD DISORDERS ADVANCED
PATHOPHYSIOLOGY
(CHAMBERLAIN UNIVERSITY)
NR507 WEEK 5 EDAPT
MOOD DISORDERS
Introduction to Mood Disorders
Mood disorders are abnormalities in mood occurring across a
spectrum from depression to mania, affecting between 10-20% of the
population (Coleman et al., 2020). Mood disorders include depressive
disorders and bipolar disorders and may be comorbid with other
physical and psychological conditions. Without effective treatment,
mood disorders may impact day-to-day living and the ability to relate
to others.
Associated with Mood
# Client Statement
Disorder?
1 “I often have bouts of extreme sadness and irritability.” ✅ Yes
“I spent last week’s wages on makeup and workout
2 ✅ Yes
clothes.”
“Yesterday, I had difficulty deciding what to cook for
3 ❌ No
supper.”
4 “I often go days without sleeping.” ✅ Yes
“I often have bouts of extreme sadness and racing
5 ✅ Yes
thoughts.”
“I feel so hopeless and often can’t get out of bed to go
6 ✅ Yes
to work.”
“I will never be good enough for my husband’s
7 ✅ Yes
family.”
,NR507 Week 5 Edapt Mood Disorders
Introduction to Mood Disorders
Mood disorders are abnormalities in mood occurring across a spectrum from depression to
mania, affecting between 10-20% of the population (Coleman et al., 2020). Mood disorders
include depressive disorders and bipolar disorders and may be comorbid with other physical
and psychological conditions. Without effective treatment, mood disorders may impact day-
to-day living and the ability to relate to others.
Depressive symptoms in mood disorders may include persistent feelings of hopelessness
and sadness or expressing self-negativity. Individuals with mood disorders often experience
persistent and intense fluctuations in mood, ranging from extreme sadness or despair
alternating with periods of elevated mood or irritability. In bipolar disorder, individuals who
experience episodes of mania or hypomania may be characterized by elevated mood,
increased energy, racing thoughts, impulsivity, inflated self- esteem or grandiosity,
decreased need for sleep, excessive involvement in activities, and risky behaviors such as
reckless spending or substance abuse.
An isolated breach in decision-making (e.g., cooking supper) is not related to a mood disorder.
Clients with unipolar disorder will likely experience high self-esteem during a manic episode.
The same symptoms characterize unipolar depression as major depressive disorder (MDD).
Bipolar, not unipolar, depression is characterized by extreme agitation and hallucinations.
, Dopamine is synthesized from the amino acid tyrosine, and its synthesis plays a role in
neurotransmission. Alterations of dopamine on receptors can affect mood, pleasure, and
motivation.
Glutamate, not dopamine, affects sleep cycles.
Pathophysiology of Mood Disorders
Mood disorders involve disturbances in mood that occur across a spectrum from depression
to mania. Mood disorders cause distressing symptoms for clients, often impacting daily
functioning and disrupting social relationships.
The exact pathophysiology of these disorders remains unclear but likely involves a
combination of genetic, chemical, and environmental factors. Neurotransmitters modulate
communication between neurons in the brain and influence various aspects of mood
regulation. Imbalances or dysregulation in neurotransmitter levels, such as serotonin,
dopamine, and norepinephrine, are commonly implicated in the development and
manifestation of mood disorders. Decreased levels of serotonin have been associated with
symptoms of depression, while abnormalities in dopamine and norepinephrine transmission
are linked to mood disturbances characteristic of conditions like bipolar disorder.
Individuals with family members who have bipolar disorder are also more likely to develop
the condition. The interaction between genetic factors, chemicals, and the environment may
be contributory.
Pathophysiology of Bipolar Disorders
Bipolar disorder is a mental illness that causes extreme shifts in emotions, mood, and
energy levels. Shifts in mood usually occur over several days to weeks. Although bipolar
disorder can be diagnosed at any age, it is most frequently diagnosed in late adolescence
or early 20s and is considered a lifelong condition.
The exact cause of bipolar disorder is unknown. Individuals with family members who have
bipolar disorder are more likely to develop the condition. The interaction between genetic
factors and the
PATHOPHYSIOLOGY
(CHAMBERLAIN UNIVERSITY)
NR507 WEEK 5 EDAPT
MOOD DISORDERS
Introduction to Mood Disorders
Mood disorders are abnormalities in mood occurring across a
spectrum from depression to mania, affecting between 10-20% of the
population (Coleman et al., 2020). Mood disorders include depressive
disorders and bipolar disorders and may be comorbid with other
physical and psychological conditions. Without effective treatment,
mood disorders may impact day-to-day living and the ability to relate
to others.
Associated with Mood
# Client Statement
Disorder?
1 “I often have bouts of extreme sadness and irritability.” ✅ Yes
“I spent last week’s wages on makeup and workout
2 ✅ Yes
clothes.”
“Yesterday, I had difficulty deciding what to cook for
3 ❌ No
supper.”
4 “I often go days without sleeping.” ✅ Yes
“I often have bouts of extreme sadness and racing
5 ✅ Yes
thoughts.”
“I feel so hopeless and often can’t get out of bed to go
6 ✅ Yes
to work.”
“I will never be good enough for my husband’s
7 ✅ Yes
family.”
,NR507 Week 5 Edapt Mood Disorders
Introduction to Mood Disorders
Mood disorders are abnormalities in mood occurring across a spectrum from depression to
mania, affecting between 10-20% of the population (Coleman et al., 2020). Mood disorders
include depressive disorders and bipolar disorders and may be comorbid with other physical
and psychological conditions. Without effective treatment, mood disorders may impact day-
to-day living and the ability to relate to others.
Depressive symptoms in mood disorders may include persistent feelings of hopelessness
and sadness or expressing self-negativity. Individuals with mood disorders often experience
persistent and intense fluctuations in mood, ranging from extreme sadness or despair
alternating with periods of elevated mood or irritability. In bipolar disorder, individuals who
experience episodes of mania or hypomania may be characterized by elevated mood,
increased energy, racing thoughts, impulsivity, inflated self- esteem or grandiosity,
decreased need for sleep, excessive involvement in activities, and risky behaviors such as
reckless spending or substance abuse.
An isolated breach in decision-making (e.g., cooking supper) is not related to a mood disorder.
Clients with unipolar disorder will likely experience high self-esteem during a manic episode.
The same symptoms characterize unipolar depression as major depressive disorder (MDD).
Bipolar, not unipolar, depression is characterized by extreme agitation and hallucinations.
, Dopamine is synthesized from the amino acid tyrosine, and its synthesis plays a role in
neurotransmission. Alterations of dopamine on receptors can affect mood, pleasure, and
motivation.
Glutamate, not dopamine, affects sleep cycles.
Pathophysiology of Mood Disorders
Mood disorders involve disturbances in mood that occur across a spectrum from depression
to mania. Mood disorders cause distressing symptoms for clients, often impacting daily
functioning and disrupting social relationships.
The exact pathophysiology of these disorders remains unclear but likely involves a
combination of genetic, chemical, and environmental factors. Neurotransmitters modulate
communication between neurons in the brain and influence various aspects of mood
regulation. Imbalances or dysregulation in neurotransmitter levels, such as serotonin,
dopamine, and norepinephrine, are commonly implicated in the development and
manifestation of mood disorders. Decreased levels of serotonin have been associated with
symptoms of depression, while abnormalities in dopamine and norepinephrine transmission
are linked to mood disturbances characteristic of conditions like bipolar disorder.
Individuals with family members who have bipolar disorder are also more likely to develop
the condition. The interaction between genetic factors, chemicals, and the environment may
be contributory.
Pathophysiology of Bipolar Disorders
Bipolar disorder is a mental illness that causes extreme shifts in emotions, mood, and
energy levels. Shifts in mood usually occur over several days to weeks. Although bipolar
disorder can be diagnosed at any age, it is most frequently diagnosed in late adolescence
or early 20s and is considered a lifelong condition.
The exact cause of bipolar disorder is unknown. Individuals with family members who have
bipolar disorder are more likely to develop the condition. The interaction between genetic
factors and the
