Activation of GABA Correct Answers Receptor activation
increases chloride conductance through an ion channel
Adipose tissue r/t distrbution Correct Answers adipose tissue
poorly perfused so distribution is slow
Administering Propofol consideration Correct Answers Pain on
injection d/t the free aqueous concentration
administration of Barbiturates Correct Answers pain on
injection common, expecially with methohexital
All NMDA tetramer subunits contain what Correct Answers an
NRI subunit and at least 4 types of NR2 subunits (A-D)
Arrangment of tetramer subunits Correct Answers arranged
circumferentially around a central ion channel pore
Barbiturates action Correct Answers blocks the action of the
excitatory neurotransmitter glutamate at AMPA and kainate
receptor subtypes, but not at NMDA recepors
Barbiturates associated with what response Correct Answers
histamine release
Barbiturates bioavailability Correct Answers highly protein
bound (75-90%)
increased free drug on low albumin
, Barbiturates elimination Correct Answers deactivation and
excretion in the liver
Barbiturates give to acidic patient Correct Answers decreased
dose requirement
Barbiturates in solution Correct Answers weak acids
Barbiturates inhibit what Correct Answers neuronal nicotinic
acetylcholine receptors
Barbiturates inhibits? Correct Answers inhibits neuronal
nicotinic acetylcholine receptors
Barbiturates MOA (thiopental, methohexital, pentobarbital)
Correct Answers enhances GABAa receptor function and
decreases the rate of disassociation of GABA
Barbiturates modulation Correct Answers modulates a variety
of ligand gated ion channels
Barbiturates produces what? Correct Answers dose depedent
CNS depression
Barbiturates terminatation process Correct Answers
redistribution
Benzodiazepines are thought to interact Correct Answers
between the α and γ subunits