PHARMACOLOGY modules 6-8 (pain, musculoskeletal,
substance abuse) Questions With Complete Solutions
Opioid antagonists such as naloxone and naltrexone are used to
treat acute drug overdoses, Because these drugs have short half-
lives, it is important to monitor for
a. Aspiration
b. Recurrence of respiratory depression
c. Misuse
d. Tachycardia
b. Recurrence of respiratory depression
Codeine is a prodrug that is metabolized by CYP2D6 into
morphine (active metabolite). Which of the following is TRUE
regarding pharmacogenomic differences between CYP2D6 in
patients who are nonmetabolizers or ultrametabolizers compared
to normal metabolizers?
a. Ultra-rapid metabolizers may develop very high levels of
morphine in the blood, leading to respiratory depression.
b. Those who don't metabolize the drug to its active form won't
get any analgesic benefit from the drug.
c. Infants and children who are rapid metabolizers have an
increased risk of adverse drug reactions to codeine.
d. Lactating women who are ultrametabolizers should avoid
codeine while breastfeeding.
e. All of the above
e. All of the above
,Which of the following best describes acute abstinence
syndrome?
a. Occurs only if the opioid antagonist is titrated slowly.
b. Opioid antagonist use induces opioid withdrawal.
c. Causes central nervous system (CNS) depression.
d. Opioid antagonist use can cause severe pain in postoperative
patients.
e. A and C
f. B and D
f. B and D
Which of the following best describes acute abstinence
syndrome?
a. Occurs only if the opioid antagonist is titrated slowly.
b. Opioid antagonist use induces opioid withdrawal.
c. Causes central nervous system (CNS) depression.
d. Opioid antagonist use can cause severe pain in postoperative
patients.
e. A and C
f. B and D
f. B and D
Transdermal fentanyl is a good option for acute pain due to a
traumatic injury.
True or False
False
, Which of the following attributes makes methadone useful for
treatment of chronic and neuropathic pain?
a. It is a N-methyl-D-aspartate agonist.
b. t is a N-methyl-D-aspartate antagonist.
It does not cause sedation.
d. It is less addictive than other opioid analgesics.
b. t is a N-methyl-D-aspartate antagonist.
You are an NP in the emergency department (ED). You
prescribe oxycodone 5 mg orally every 4 hours as needed for
severe pain to a patient with an acute tibial fracture. What
education would you provide the patient regarding the use of
alcohol or sedatives while taking oxycodone?
Monitor for respiratory depression.
Which of the following is correct regarding infants born to
mothers with chronic opioid use?
a. Respiratory depression
b. Sedation
c. Withdrawal
d. All of these
d. All of these
How do NSAIDs contribute to gastric bleeding?
a. Local COX-1 inhibition decreases gastric acid production.
b. Local COX-1 inhibition prevents the cytoprotective effects of
substance abuse) Questions With Complete Solutions
Opioid antagonists such as naloxone and naltrexone are used to
treat acute drug overdoses, Because these drugs have short half-
lives, it is important to monitor for
a. Aspiration
b. Recurrence of respiratory depression
c. Misuse
d. Tachycardia
b. Recurrence of respiratory depression
Codeine is a prodrug that is metabolized by CYP2D6 into
morphine (active metabolite). Which of the following is TRUE
regarding pharmacogenomic differences between CYP2D6 in
patients who are nonmetabolizers or ultrametabolizers compared
to normal metabolizers?
a. Ultra-rapid metabolizers may develop very high levels of
morphine in the blood, leading to respiratory depression.
b. Those who don't metabolize the drug to its active form won't
get any analgesic benefit from the drug.
c. Infants and children who are rapid metabolizers have an
increased risk of adverse drug reactions to codeine.
d. Lactating women who are ultrametabolizers should avoid
codeine while breastfeeding.
e. All of the above
e. All of the above
,Which of the following best describes acute abstinence
syndrome?
a. Occurs only if the opioid antagonist is titrated slowly.
b. Opioid antagonist use induces opioid withdrawal.
c. Causes central nervous system (CNS) depression.
d. Opioid antagonist use can cause severe pain in postoperative
patients.
e. A and C
f. B and D
f. B and D
Which of the following best describes acute abstinence
syndrome?
a. Occurs only if the opioid antagonist is titrated slowly.
b. Opioid antagonist use induces opioid withdrawal.
c. Causes central nervous system (CNS) depression.
d. Opioid antagonist use can cause severe pain in postoperative
patients.
e. A and C
f. B and D
f. B and D
Transdermal fentanyl is a good option for acute pain due to a
traumatic injury.
True or False
False
, Which of the following attributes makes methadone useful for
treatment of chronic and neuropathic pain?
a. It is a N-methyl-D-aspartate agonist.
b. t is a N-methyl-D-aspartate antagonist.
It does not cause sedation.
d. It is less addictive than other opioid analgesics.
b. t is a N-methyl-D-aspartate antagonist.
You are an NP in the emergency department (ED). You
prescribe oxycodone 5 mg orally every 4 hours as needed for
severe pain to a patient with an acute tibial fracture. What
education would you provide the patient regarding the use of
alcohol or sedatives while taking oxycodone?
Monitor for respiratory depression.
Which of the following is correct regarding infants born to
mothers with chronic opioid use?
a. Respiratory depression
b. Sedation
c. Withdrawal
d. All of these
d. All of these
How do NSAIDs contribute to gastric bleeding?
a. Local COX-1 inhibition decreases gastric acid production.
b. Local COX-1 inhibition prevents the cytoprotective effects of
