TEST BANK
BRENNER AND STEVENS’ PHARMACOLOGY
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TABLE OF CONTENTS
Section I PRINCIPLES OF PHARMACOLOGY
1. Introduction to Pharmacology and Drug Names
2. Pharmacokinetics or What the Body Does to the Drug
3. Pharmacodynamics or What the Drug Does to the Body
4. Drug Development and Drug Safety 35
5. Toxicology Principles and the Treatment of Poisoning
Section II AUTONOMIC AND NEUROMUSCULAR PHARMACOLOGY
6. Parasympathetic, Neuromuscular Pharmacology, and Cholinergic Agonists
7. Cholinergic Receptor Antagonists
8. Sympathetic Neuropharmacology and Adrenergic Agonists
9. Adrenergic Receptor Antagonists
Section III CARDIOVASCULAR, RENAL, AND HEMATOLOGIC
PHARMACOLOGY
10. Antihypertensive Drugs
11. Antianginal Drugs
12. Drugs for the Treatment of Heart Failure
13. Diuretic Drugs
14. Drugs for Cardiac Dysrhythmia
15. Drugs for Hyperlipidemia
16. Antithrombotic and Thrombolytic Drugs
17. Hematopoietic Drugs
Section IV CENTRAL NERVOUS SYSTEM PHARMACOLOGY
18. Introduction to Central Nervous System Pharmacology
19. Sedative-Hypnotic and Anxiolytic Drugs
20. Antiepileptic Drugs
21. Local and General Anesthetics
22. Psychotherapeutic Drugs
23. Opioid Analgesics and Antagonists
24. Drugs for Neurodegenerative Diseases
25. Drugs of Abuse
Section V PHARMACOLOGY OF RESPIRATORY AND OTHER SYSTEMS
26. Autacoid Drugs That Mimic Endogenous Substances
27. Pharmacological Treatment of Respiratory Disorders
28. Pharmacological Treatment of Gastrointestinal Disorders
29. Drugs for Headache Disorders
30. Drugs for Pain, Inflammation, and Arthritic Disorders
Section VI ENDOCRINE PHARMACOLOGY
31. Hypothalamic and Pituitary Hormone Drugs
32. Drugs for the Treatment of Thyroid Disorders
33. Adrenal Steroids and Related Drugs
34. Fertility and Reproduction Drugs
35. Drugs for the Treatment of Diabetes
36. Drugs Affecting Calcium and Bone Formation
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Section VII ANTIMICROBIAL AND CHEMOTHERAPEUTIC AGENTS
37. Principles of Antimicrobial Chemotherapy
38. Antibiotics That Inhibit Bacterial Cell Wall Synthesis
39. Antibiotics That Inhibit Bacterial Protein Synthesis
40. Other Antimicrobial Agents Such as Quinolones and Antifolate Drugs
41. Antimycobacterial Drugs for Treating Tuberculosis and Other Diseases
42. Drugs for the Treatment of Fungal Infections
43. Drugs for the Treatment of Viral Infections
44. Drugs for the Treatment of Parasites
45. Antineoplastic Agents
46. Immunopharmacology, Biologicals, and Gene Therapy
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BRENNER AND STEVENS’ PHARMACOLOGY 6TH EDITION TEST BANK
Chapter 1 Introduction To Pharmacology
A Nurse Working In Radiology Administers Iodine To A Patient Who Is
Having A Computed Tomography (CT) Scan. The Nurse Working On The
Oncology Unit Administers Chemotherapy To Patients Who Have Cancer. At
The Public Health Department, A Nurse Administers A Measles-Mumps-
Rubella (MMR) Vaccine To A 14-Month-Old Child As A Routine
Immunization. Which Branch Of Pharmacology
1. Best Describes The Actions Of All Three Nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Answer: B
Feedback:
Pharmacology Is The Study Of The Biologic Effects Of Chemicals. Nurses Are
Involved With Clinical Pharmacology Or Pharmacotherapeutics, Which Is A
Branch Of Pharmacology That Deals With The Uses Of Drugs To Treat, Prevent,
And Diagnose Disease. The Radiology Nurse Is Administering A Drug To Help
Diagnose A Disease. The Oncology Nurse Is Administering A Drug To Help
Treat A Disease.
Pharmacoeconomics Includes Any Costs Involved In Drug Therapy.
Pharmacodynamics Involves How A Drug Affects The Body And Pharmacokinetics
Is How The Body Acts On The Body.
A Physician Has Ordered Intramuscular (IM) Injections Of Morphine, A Narcotic,
Every 4 Hours As Needed For Pain In A Motor Vehicle Accident Victim. The
Nurse Is Aware This Drug Has A High Abuse Potential. Under What Category
Would Morphine
2. Be Classified?
A) Schedule I
B) Schedule II
C) Schedule III
D) Schedule IV
Answer: B
Feedback:
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Narcotics With A High Abuse Potential Are Classified As Schedule II Drugs
Because Of Severe Dependence Liability. Schedule I Drugs Have High Abuse
Potential And No Accepted Medical Use. Schedule III Drugs Have A Lesser
Abuse Potential Than II And An Accepted Medical Use. Schedule IV Drugs
Have Low Abuse Potential And Limited Dependence Liability.
When Involved In Phase III Drug Evaluation Studies, What Responsibilities Would
3. The Nurse Have?
A) Working With Animals Who Are Given Experimental Drugs
B) Choosing Appropriate Patients To Be Involved In The Drug Study
C) Monitoring and observing patients closely for adverse effects
D) Conducting research to determine effectiveness of the drug
Ans: C
Feedback:
Phase III studies involve use of a drug in a vast clinical population in which
patients are asked to record any symptoms they experience while taking the
drugs. Nurses may be responsible for helping collect and analyze the information
to be shared with the Food and Drug Administration (FDA) but would not
conduct research independently because nurses do not prescribe medications. Use
of animals in drug testing is done in the preclinical trials. Select patients who are
involved in phase II studies to participate in studies where the participants have
the disease the drug is intended to treat. These patients are monitored closely for
drug action and adverse effects. Phase I studies involve healthy human volunteers
who are usually paid for their participation. Nurses may observe for adverse
effects and toxicity.
What concept is considered when generic drugs are substituted for brand name
4. drugs?
A) Bioavailability
B) Critical Concentration
C) Distribution
D) Half-Life
Answer: A
Feedback:
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Bioavailability Is The Portion Of A Dose Of A Drug That Reaches The Systemic
Circulation And Is Available To Act On Body Cells. Binders Used In A Generic
Drug May Not Be The Same As Those Used In The Brand Name Drug.
Therefore, The Way The Body Breaks Down And Uses The Drug May Differ,
Which May Eliminate A Generic Drug Substitution. Critical Concentration Is
The Amount Of A Drug That Is Needed To Cause A Therapeutic Effect And
Should Not Differ Between Generic And Brand Name Medications. Distribution
Is The Phase Of Pharmacokinetics, Which Involves The Movement Of A Drug
To The Bodys Tissues And Is The Same In Generic And Brand Name Drugs. A
Drugs Half-Life Is The Time It Takes For The Amount Of Drug To Decrease To
Half The Peak Level, Which Should Not Change When Substituting A Generic
Medication.
A nurse is assessing the patients home medication use. After listening to the
5. patient list current medications, the nurse asks what priority question?
A) Do you take any generic medications?
B) Are any of these medications orphan drugs?
C) Are these medications safe to take during pregnancy?
D) Do you take any over-the-counter medications?
Ans: D
Feedback:It is important for the nurse to specifically question use of over-the-
counter medications because patients may not consider them important. The
patient is unlikely to know the meaning of orphan drugs unless they too are health
care providers. Safety during pregnancy, use of a generic medication, or
classification of orphan drugs are things the patient would be unable to answer but
could be found in reference books if the nurse wishes to research them.
After Completing A Course On Pharmacology For Nurses, What Will The Nurse
6. Know?
A) Everything Necessary For Safe And Effective Medication
Administration Current Pharmacologic Therapy; The Nurse Will Not
Require Ongoing
B) Education For 5 Years.
General Drug Information; The Nurse Can Consult A Drug Guide For
Specific
C) Drug Information.
D) The Drug Actions That Are Associated With Each Classification Of
Medication Answer: C
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Feedback:
After Completing A Pharmacology Course Nurses Will Have General Drug
Information Needed For Safe And Effective Medication Administration But Will
Need To Consult A Drug Guide For Specific Drug Information Before
Administering Any Medication. Pharmacology Is Constantly Changing, With
New Drugs Entering The Market And New Uses For Existing Drugs Identified.
Continuing Education In Pharmacology Is Essential To Safe Practice. Nurses
Tend To Become Familiar With The Medications They Administer Most Often,
But There Will Always Be A Need To Research New Drugs And Also Those
The Nurse Is Not Familiar With Because No Nurse Knows All Medications.
A Nurse Is Instructing A Pregnant Patient Concerning The Potential Risk To Her
Fetus
7. From A Pregnancy Category B Drug. What Would The Nurse Inform The Patient?
Adequate Studies In Pregnant Women Have Demonstrated There Is No Risk
To
A) The Fetus.
Animal Studies Have Not Demonstrated A Risk To The Fetus, But There
Have
B) Been No Adequate Studies In Pregnant Women.
Animal Studies Have Shown An Adverse Effect On The Fetus, But There Are
No
C) Adequate Studies In Pregnant Women.
There Is Evidence Of Human Fetal Risk, But The Potential Benefits From
Use Of
D) The Drug May Be Acceptable Despite Potential
Risks. Answer: B
Feedback:
Category B Indicates That Animal Studies Have Not Demonstrated A Risk To
The Fetus. However, There Have Not Been Adequate Studies In Pregnant
Women To Demonstrate Risk To A Fetus During The First Trimester Of
Pregnancy And No Evidence Of Risk In Later Trimesters. Category A Indicates
That Adequate Studies In Pregnant Women Have Not Demonstrated A Risk To
The Fetus In The First Trimester Or In Later Trimesters. Category C Indicates
That Animal Studies Have Shown An Adverse Effect On The Fetus, But No
Adequate Studies In Humans. Category D Reveals Evidence Of Human Fetal
Risk, But The Potential Benefits From The Use Of The Drugs In Pregnant
Women May Outweigh Potential Risks.
Discharge Planning For Patients Leaving The Hospital Should Include
Instructions On The Use Of Over-The-Counter (OTC) Drugs. Which
Comment By The Patient
8. Would Demonstrate A Good Understanding Of OTC Drugs?
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A) OTC Drugs Are Safe And Do Not Cause Adverse Effects If Taken Properly.
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OTC Drugs Have Been Around For Years And Have Not Been Tested By The
B) Food And Drug Administration (FDA).
OTC Drugs Are Different From Any Drugs Available By Prescription And
Cost
C) Less.
D) OTC Drugs Could Cause Serious Harm If Not Taken According To
Directions. Answer:D
Feedback:
It Is Important To Follow Package Directions Because Otcs Are Medications
That Can Cause Serious Harm If Not Taken Properly. Otcs Are Drugs That Have
Been Determined To Be Safe When Taken As Directed; However, All Drugs
Can Produce Adverse Effects Even When Taken Properly. They May Have
Originally Been Prescription Drugs That Were Tested By The FDA Or They
May Have Been Grandfathered In When The FDA Laws Changed. OTC
Education Should Always Be Included As A Part Of The Hospital Discharge
Instructions.
9. What Would Be The Best Source Of Drug Information For A Nurse?
A) Drug Facts And Comparisons
B) A Nurses Drug Guide
C) A Drug Package Insert
D) The Physicians Drug Reference (PDR)
Answer: B
Feedback:
A Nurses Drug Guide Provides Nursing Implications And Patient Teaching
Points That Are Most Useful To Nurses In Addition To Need-To-Know Drug
Information In A Very User Friendly Organizational Style.Lippincotts Nursing
Drug Guide (LNDG) Has Drug Monographs Organized Alphabetically And
Includes Nursing Implications And Patient Teaching Points. Numerous Other
Drug Handbooks Are Also On The Market And Readily Available For Nurses
To Use. Although Other Drug Reference Books Such As Drug Facts And
Comparisons, PDR, And Drug Package Inserts Can All Provide Essential Drug
Information, They Will Not Contain Nursing Implications And Teaching Points
And Can Be More Difficult To Use Than Nurses Drug Guides.
The Nurse Is Preparing To Administer A Medication From A Multidose Bottle.
The Label Is Torn And Soiled But The Name Of The Medication Is Still
Readable. What Is
10. The Nurses Priority Action?
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