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- Is derived from Greek word for "crab"— karkinoma.
- Is another name for malignant tumour.
What is cancer? - Cancer is not a tumour.
- Is an abnormal growth resulting from uncontrolled
proliferation; it serves no physiologic function.
•Genes, epigenetics and tissue
What factors can lead to •Incidence and mortality trends
the development of •In utero and early life conditions
cancer? •Environmental-lifestyle factors (e.g., tobacco,
nutrition, obesity, alcohol, physical activity etc)
, •Environmental-lifestyle behaviors and genetic factors
contribute to cancers.
•Cancer is driven by genetic alterations and changes
in epigenetic regulation.
•Cancer development and progression involve tissue
microenvironment or stroma.
•Infiltrating immune cells cause chronic inflammation,
How do genetics and creating a permissive tumour-progressing
epigenetics contribute to environment.
cancer? •Epigenetic processes influence cancer initiation,
progression, and treatment.
•Factors that influence cancer risk
•Detoxifying enzymes
•DNA repair genes
•Immune/inflammatory systems
•Cell's immediate environment
•Metabolic/hormonal factors
Incident
- Overall cancer rates are higher for men than women.
- Highest cancer rates are found in Denmark.
- Decline in lung cancer correlates to decreased
What is significant about tobacco use.
the incidence and - Cancer rates have increased for ages 0-19.
mortality trends of Mortality
cancer? - Cancer deaths have decreased in men, women,
children.
- Liver cancer is most predominant cancer.
- Mortality rates for men with liver cancer are more
than double the rate for women.