PAT 202: Week 7 - Alterations in Cognitive
Systems & Motor Function Questions and
Answers
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Terms in this set (56)
Alterations in COGNITIVE systems
e.g., Dementia, Alzheimer Disease, seizure
Alterations in CEREBRAL HEMODYNAMICS
Ex. increase intracranial pressure, cerebral edema,
What are the 3 types of
hydrocephalus
alterations?
Alterations in NEUROMOTOR FUNCTION
e.g., Parkinson Disease
*multiple sclerosis is an autoimmune disease
- Alterations in arousal (state of awakeness) &
Define Alterations in awareness (content of thought)
Cognitive Systems - Data processing deficits
- Seizure disorders
Is a seizure disorder No, it is a manifestation of a disease
considered a disease?
, -Agnosia (can't recognize objects)
-Aphasia (can't understand language; impaired
written/verbal communication)
What are the 5 types of
-Acute confusion state of delirium (sudden/gradual)
data processing deficits?
-Dementia (progressive failure of cerebral functions
that cause impairment)
-Alzheimers (irreversible,)
What is the leading cause Alzheimer disease
of dementia?
-Impairment of intellectual function, memory,
What are the clinical
decision-making, and language
manifestations of
-Alterations in behaviour
dementia?
ex. agitation, wandering aggression
Delirium is acute, has abrupt onset, ANS is overactive,
is common in withdrawal from CNS depressants
How is Delirium different
from Dementia? Dementia is a progressive failure of cerebral function,
has gradual onset, can produce nerve cell
degeneration and brain atrophy
What is the greatest risk Age!
factor for dementia and
Alzheimer disease?
What is the name of the Dementia of the Alzheimer type (DAT)
Alzheimer's Disease that is
a chronic, progressive
disease that profoundly
diminishes memory,
reasoning ability, and
thinking skills?
Which type of Alzheimer's - sporadic AD: late onset and 90% of AD population
Disease has a late onset - familial AD: early onset and 10%
and is more common:
familial AD or sporadic
AD?
, Early-onset familial AD
-Autosomal dominant
-Linked to 3 gene mutations on chromosome 21
Late-onset AD
Differentiate between
-Related to gene on chromosome 19, which interferes
early-onset familial AD,
with amyloid beta clearance from brain
late-onset AD and
-Amyloid can be processed into neurotoxic fragments
sporadic late-onset AD.
found in plaques and tangles
Sporadic late-onset AD
-does NOT have a specific gene association
-most common
-Failure to clear amyloid precursor protein →
accumulation toxic fragments of amyloid beta protein
Define Amyloid. → formation of diffuse neuritic plaques, disruption of
nerve impulse transmission and neuronal death
-Deposited in cerebral arteries impairing blood flow
Tau protein (a microtubule-binding protein)
-Forms an insoluble filament called a neurofibrillary
Define Tau proteins. tangle, contributing to neuronal death (*they're dying
in the brain; lack of acetylcholine)
-Tangles are flame shaped
What hormone is there a Loss of Acetylcholine
loss of during the
degeneration of basal
forebrain cholinergic
neurons in people with
Alzheimer's?
Systems & Motor Function Questions and
Answers
Save
Terms in this set (56)
Alterations in COGNITIVE systems
e.g., Dementia, Alzheimer Disease, seizure
Alterations in CEREBRAL HEMODYNAMICS
Ex. increase intracranial pressure, cerebral edema,
What are the 3 types of
hydrocephalus
alterations?
Alterations in NEUROMOTOR FUNCTION
e.g., Parkinson Disease
*multiple sclerosis is an autoimmune disease
- Alterations in arousal (state of awakeness) &
Define Alterations in awareness (content of thought)
Cognitive Systems - Data processing deficits
- Seizure disorders
Is a seizure disorder No, it is a manifestation of a disease
considered a disease?
, -Agnosia (can't recognize objects)
-Aphasia (can't understand language; impaired
written/verbal communication)
What are the 5 types of
-Acute confusion state of delirium (sudden/gradual)
data processing deficits?
-Dementia (progressive failure of cerebral functions
that cause impairment)
-Alzheimers (irreversible,)
What is the leading cause Alzheimer disease
of dementia?
-Impairment of intellectual function, memory,
What are the clinical
decision-making, and language
manifestations of
-Alterations in behaviour
dementia?
ex. agitation, wandering aggression
Delirium is acute, has abrupt onset, ANS is overactive,
is common in withdrawal from CNS depressants
How is Delirium different
from Dementia? Dementia is a progressive failure of cerebral function,
has gradual onset, can produce nerve cell
degeneration and brain atrophy
What is the greatest risk Age!
factor for dementia and
Alzheimer disease?
What is the name of the Dementia of the Alzheimer type (DAT)
Alzheimer's Disease that is
a chronic, progressive
disease that profoundly
diminishes memory,
reasoning ability, and
thinking skills?
Which type of Alzheimer's - sporadic AD: late onset and 90% of AD population
Disease has a late onset - familial AD: early onset and 10%
and is more common:
familial AD or sporadic
AD?
, Early-onset familial AD
-Autosomal dominant
-Linked to 3 gene mutations on chromosome 21
Late-onset AD
Differentiate between
-Related to gene on chromosome 19, which interferes
early-onset familial AD,
with amyloid beta clearance from brain
late-onset AD and
-Amyloid can be processed into neurotoxic fragments
sporadic late-onset AD.
found in plaques and tangles
Sporadic late-onset AD
-does NOT have a specific gene association
-most common
-Failure to clear amyloid precursor protein →
accumulation toxic fragments of amyloid beta protein
Define Amyloid. → formation of diffuse neuritic plaques, disruption of
nerve impulse transmission and neuronal death
-Deposited in cerebral arteries impairing blood flow
Tau protein (a microtubule-binding protein)
-Forms an insoluble filament called a neurofibrillary
Define Tau proteins. tangle, contributing to neuronal death (*they're dying
in the brain; lack of acetylcholine)
-Tangles are flame shaped
What hormone is there a Loss of Acetylcholine
loss of during the
degeneration of basal
forebrain cholinergic
neurons in people with
Alzheimer's?
