PAT 202: Diabetes
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- Recurrent infections.
- General pruritus'.
- Visual changes.
- Paresthesia.
- Fatigue.
- Acanthosis nigricans.
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1 Pancreas 2 Increased glycogenesis
3 Type 2 diabetes manifestations 4 Beta cells
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Terms in this set (56)
, - Regulates the level of sugar in the blood.
Pancreas - Located beneath the liver and tucked into the curvature of duodenum.
- Exocrine and endocrine functions.
- Secretes enzymes into duodenum to support digestion of macromolecules.
Exocrine
- Secretes bicarbonate into duodenum to raise pH of chyme.
Islets of Langerhans includes two type of cells that secrete hormones, alpha and
Endocrine
beta.
Alpha cells Secrete glucagon in response to low blood glucose and to activity of SNS.
Beta cells Secrete insulin in response to high blood glucose and to activity of PNS.
Glucose Preferred source of energy to produce ATP by cells of body.
Range of BG during fasting 4-7 mmol/L
Range of BG 2 hours after meal 5-10 mmol/L
- Secreted in response to increased BG.
Insulin
- Decreases BG levels.
Glucose transport - Increased uptake by GLUT-4 receptors into skeletal muscle & adipose tissue.
- Inhibits breakdown of glycogen to glucose.
Decreased glycogenolysis
- Occurs in insulin.
- Inhibits making of glucose from non-carbs.
Decreased gluconeogenesis
- Occurs in insulin.
- Turns glucose into glycogen (promotes glycogen storage).
Increased glycogenesis
- Occurs in insulin.
- A protein hormone secreted by pancreatic endocrine cells that raises blood
glucose levels; an antagonistic hormone to insulin.
Glucagon
- Secreted when BG is low.
- Increases BG.
- Breaks down glycogen to glucose.
Increased glycogenolysis
- Occurs in glucagon.
- Turns non-carbs (fat & protein) into glucose.
Increased gluconeogenesis
- Occurs in glucagon.
1. Pancreas produces insulin
High blood glucose 2. Cells take up glucose from blood / liver produces glycogen.
3. Blood glucose falls.
1. Pancreas release glucagon.
Low blood glucose 2. Liver breaks down glycogen.
3. Blood glucose rises.
- Specialized membrane carrier proteins that are responsible for the active transport
of glucose into muscle cells.
Glucose transporters (GLUT)
- Insulin promotes formation of glucose transporters (GLUT4) that brings glucose
into cells.
Fast acting hyperglycemic hormones Glucagon and epinephrine.
Growth hormone, glucocorticoid hormones
Slow acting hyperglycemic hormones
(cortisol).
- A dysfunction of pancreatic endocrine function.
Diabetes
- Affects metabolism of carbohydrates, fat, and protein.