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GNRS 610 ADVANCED PATHOPHYSIOLOGY
HEMATOLOGY Exam 2 QUESTIONS with 100%
Verified Answers Latest Versions 2026 Top Rated
A+
Sickle cell disease (SCD) is inherited in an fashion.
a. Autosomal dominant
b. Autosomal recessive
c. X-linked dominant
d. X-linked recessive Correct Answer>>B Autosomal recessive
SCD is an inherited autosomal recessive disorder that is expressed as sickle cell
anemia.
Sickle cell-thalassemia disease, and sickle cell-Hb C disease also occur.
Hemoglobin S (Hb S) is formed as a result of a(n):
a. Deficiency in G6PD that changes Hb A to Hb S
b. Genetic mutation in which two amino acids (histidine and leucine) are
missing
Page 1 of 49
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c. Genetic mutation in which one amino acid (valine) replaces another (glutamic
acid)
d. Autoimmune response in which one amino acid (proline) is detected as an
antigen by abnormal IgG Correct Answer>>C Genetic mutation in which a
hydrophobic amino acid (valine) replaces a hydrophilic amino acid
(glutamic acid)
Hb S is formed by a genetic mutation in which one amino acid (valine) replaces
another (glutamic acid) of the beta chain
The hydrophobicity and the size of the side chain of the amino acid at βS26 or
the βS24 position affects the solubility of the resulting mutants
Sickle cell anemia is an inherited disorder seen in African Americans. It is
marked by the characteristic sickling of RBCs. This causes chronic hemolytic
anemia and occlusion of blood vessels. Which is NOT considered to be a trigger
of an episode of sickling?
a. Infection
b. Stress
c. Heat
d. Dehydration
e. Acidosis Correct Answer>>C Heat
Page 2 of 49
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In hemolytic anemia the RBCs are destroyed prematurely. The majority of
hemolytic anemias show:
a. Normocytic hypochromic cells
b. Microcytic normochromic cells
c. Macrocytic hyperchromic cells
d. Normocytic normochromic cells Correct Answer>>DNormocytic
normochromic cells
In hemolytic anemia, jaundice occurs when:
a. Erythrocytes are destroyed in the spleen
b. Red cell destruction exceeds the liver's ability to conjugate and excrete
bilirubin
c. The patient has elevated levels of aspartate transaminase (AST) and alanine
transaminase (ALT)
d. The erythrocytes are coated with immunoglobulin --CORRECT ANSWER--
b. Red cell destruction exceeds the liver's ability to conjugate and excrete
bilirubin
Page 3 of 49
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Jaundice (icterus) is present when heme destruction exceeds the liver's ability to
conjugate and excrete bilirubin.
The alpha- and beta-thalassemias are inherited in an fashion.
a. Autosomal recessive
b. Autosomal dominant
c. X-linked recessive
d. X-linked dominant Correct Answer>>A. Autosomal recessive
The alpha- and beta-thalassemias are inherited autosomal recessive disorders.
Aplastic anemia is a serious anemia affecting pluripotential bone marrow stem
cells and causing all three hematopoietic cell lines to be reduced. What is the
treatment for aplastic anemia in the young and severely affected client?
a. There is no treatment for aplastic anemia
b. Bone marrow transplant
c. Spleen transplant
d. Liver transplant Correct Answer>>B Bone marrow transplant
Page 4 of 49
GNRS 610 ADVANCED PATHOPHYSIOLOGY
HEMATOLOGY Exam 2 QUESTIONS with 100%
Verified Answers Latest Versions 2026 Top Rated
A+
Sickle cell disease (SCD) is inherited in an fashion.
a. Autosomal dominant
b. Autosomal recessive
c. X-linked dominant
d. X-linked recessive Correct Answer>>B Autosomal recessive
SCD is an inherited autosomal recessive disorder that is expressed as sickle cell
anemia.
Sickle cell-thalassemia disease, and sickle cell-Hb C disease also occur.
Hemoglobin S (Hb S) is formed as a result of a(n):
a. Deficiency in G6PD that changes Hb A to Hb S
b. Genetic mutation in which two amino acids (histidine and leucine) are
missing
Page 1 of 49
,@#$%^&*^%$#@$%&^*(&%$#%^&*(&^%$^&(
c. Genetic mutation in which one amino acid (valine) replaces another (glutamic
acid)
d. Autoimmune response in which one amino acid (proline) is detected as an
antigen by abnormal IgG Correct Answer>>C Genetic mutation in which a
hydrophobic amino acid (valine) replaces a hydrophilic amino acid
(glutamic acid)
Hb S is formed by a genetic mutation in which one amino acid (valine) replaces
another (glutamic acid) of the beta chain
The hydrophobicity and the size of the side chain of the amino acid at βS26 or
the βS24 position affects the solubility of the resulting mutants
Sickle cell anemia is an inherited disorder seen in African Americans. It is
marked by the characteristic sickling of RBCs. This causes chronic hemolytic
anemia and occlusion of blood vessels. Which is NOT considered to be a trigger
of an episode of sickling?
a. Infection
b. Stress
c. Heat
d. Dehydration
e. Acidosis Correct Answer>>C Heat
Page 2 of 49
,@#$%^&*^%$#@$%&^*(&%$#%^&*(&^%$^&(
In hemolytic anemia the RBCs are destroyed prematurely. The majority of
hemolytic anemias show:
a. Normocytic hypochromic cells
b. Microcytic normochromic cells
c. Macrocytic hyperchromic cells
d. Normocytic normochromic cells Correct Answer>>DNormocytic
normochromic cells
In hemolytic anemia, jaundice occurs when:
a. Erythrocytes are destroyed in the spleen
b. Red cell destruction exceeds the liver's ability to conjugate and excrete
bilirubin
c. The patient has elevated levels of aspartate transaminase (AST) and alanine
transaminase (ALT)
d. The erythrocytes are coated with immunoglobulin --CORRECT ANSWER--
b. Red cell destruction exceeds the liver's ability to conjugate and excrete
bilirubin
Page 3 of 49
, @#$%^&*^%$#@$%&^*(&%$#%^&*(&^%$^&(
Jaundice (icterus) is present when heme destruction exceeds the liver's ability to
conjugate and excrete bilirubin.
The alpha- and beta-thalassemias are inherited in an fashion.
a. Autosomal recessive
b. Autosomal dominant
c. X-linked recessive
d. X-linked dominant Correct Answer>>A. Autosomal recessive
The alpha- and beta-thalassemias are inherited autosomal recessive disorders.
Aplastic anemia is a serious anemia affecting pluripotential bone marrow stem
cells and causing all three hematopoietic cell lines to be reduced. What is the
treatment for aplastic anemia in the young and severely affected client?
a. There is no treatment for aplastic anemia
b. Bone marrow transplant
c. Spleen transplant
d. Liver transplant Correct Answer>>B Bone marrow transplant
Page 4 of 49
