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Stable Angina (Angina Pectoris)
- substernal chest pain precipitated by exertion & ↑myocardial oxygen demand
- lasts >1 minute and < 15 minutes
- relieved with rest or nitroglycerine
Stable Angina (Angina Pectoris) - presentation
- substernal chest pain
- poorly localized
- short in duration (1-15 minutes)
- exacerbated by activity
- relieved with rest or nitro
- may have dyspnea, N/V, numbness, fatigue, radiation of pain
- sometimes epigastric or shoulder pain in females, elderly, diabetic, obese
Stable Angina (Angina Pectoris) - Canadian CV Society Grading
,Stable Angina (Angina Pectoris) - diagnosis
clinical with testing
- EKG: ST-depression classic with T wave inversions and poor R wave progression
- Stress test: most important non-invasive test
- coronary angiography: is the definitive diagnostic test to define location & extent of
CAD
Stable Angina (Angina Pectoris) - treatment
reduction of risk factors: control HTN & diabetes, exercise, balanced diet, & smoking
cessation
medication: aspirin + beta-blockers + nitro PRN + statin(RF reduction)
- BB & aspirin ↓mortality
- CCB can replace BB if contraindicated
Stable Angina (Angina Pectoris) - definitive treatment
revascularization:
- PCI: 1 or 2 vessel disease in non-diabetics, not in the left main, with normal or near-
normal EF
- coronary by -pass graft: left main artery stenosis, 3 vessel disease (or 2 in diabetics),
or ↓LV EF < 40%
,Acute Coronary Syndrome (ACS)
patients experiencing either acute myocardial ischemia (i.e. lack of blood flow to heart)
OR myocardial infarction (ischemia long enough to cause heart muscle damage) &
includes:
- unstable angina
- NSTEMI
- STEMI
Unstable Angina
- chest pain that has recently started, is changing in pattern, become more frequent
(crescendo angina) and/or longer lasting
- may occur at rest and have no obvious precipitating factors
- presumed caused by obstruction, progression of CAD, thrombus, or platelet
aggregation
- negative cardiac biomarkers
Unstable Angina - presentation
chest pain with associated evidence of obstructive CAD & one of the following 3:
- began within the last 2 months
- increasing frequency, intensity, or duration of existing angina sx
- existing angina begins to occur at rest
Unstable Angina - diagnosis
clinical via H&P with diagnostics
- EKG: ST-depressions &/or T wave inversions
- Cardiac enzymes: negative enzymes
- coronary CT angiogram: narrowing of vessels
- exercise treadmill testing or nuclear stress test: reproduce EKG changes & CP
- cardiac MRI
, 3/3/26, 2:02 PM Internal Medicine EOR - PAEA
Unstable Angina - treatment
- "MONA" (morphine, O2, nitrates, aspirin*) + heparin (UFH pref) + beta-blocker
- TIMI or HEART risk assessments
***morphine only if nitrates do NOT work
*clopidogrel if ASA allergy
Coronary Artery Disease (CAD)
- #1 cause of death in the US
- due to vasospastic disease (Prinzmetal angina) OR atherosclerotic disease (stable,
unstable, STEMI, NSTEMI)
- coronary artery narrows due to build-up of atherosclerotic plaque
- characterized by angina pectoris due to ↑ oxygen demand & ↓ coronary blood
supply
Coronary Artery Disease (CAD) - risk factors
- DM (biggest risk!)
- smoking (biggest modifiable risk)
- family hx
- male sex
- dyslipidemia (↑LDL & ↓HDL)
- HTN
- physical inactivity
- abdominal obesity
& more
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