CANC 380 Module 3 Questions with
100% Correct Answers
What are tumor-associated macrophages (TAMs)? - Answer- Macrophages found close
to tumor cells, shaped by signals from the tumor microenvironment.
What are the two phenotypes of TAMs? - Answer- M1 (anti-tumor) and M2 (pro-tumor).
What do M1 TAMs do? - Answer- Suppress cancer progression and promote immune
responses against tumor cells.
What do M2 TAMs promote? - Answer- Tumor progression, angiogenesis, and immune
suppression.
What are myeloid-derived suppressor cells (MDSCs)? - Answer- A heterogeneous
population of immature myeloid cells that suppress anti-tumor immunity.
What is the role of dendritic cells in the immune response? - Answer- They are
professional antigen-presenting cells critical for initiating adaptive immune responses.
What is the function of tumor-associated neutrophils (TANs)? - Answer- They have both
pro-tumor and anti-tumor functions.
What is the tumor stroma? - Answer- The non-cancerous components surrounding and
supporting tumor cells.
What are cancer-associated fibroblasts (CAFs)? - Answer- Abundant cell types in the
tumor microenvironment that secrete tumor-promoting factors.
What is the role of the extracellular matrix (ECM) in the tumor microenvironment? -
Answer- It provides structural support and biochemical signals influencing tumor
proliferation.
What does TME stand for? - Answer- Tumor Microenvironment
What are the main components of the tumor microenvironment? - Answer- Cellular
components, extracellular components (ECM), and physical parameters (temperature,
interstitial pressure, pH, oxygen level).
100% Correct Answers
What are tumor-associated macrophages (TAMs)? - Answer- Macrophages found close
to tumor cells, shaped by signals from the tumor microenvironment.
What are the two phenotypes of TAMs? - Answer- M1 (anti-tumor) and M2 (pro-tumor).
What do M1 TAMs do? - Answer- Suppress cancer progression and promote immune
responses against tumor cells.
What do M2 TAMs promote? - Answer- Tumor progression, angiogenesis, and immune
suppression.
What are myeloid-derived suppressor cells (MDSCs)? - Answer- A heterogeneous
population of immature myeloid cells that suppress anti-tumor immunity.
What is the role of dendritic cells in the immune response? - Answer- They are
professional antigen-presenting cells critical for initiating adaptive immune responses.
What is the function of tumor-associated neutrophils (TANs)? - Answer- They have both
pro-tumor and anti-tumor functions.
What is the tumor stroma? - Answer- The non-cancerous components surrounding and
supporting tumor cells.
What are cancer-associated fibroblasts (CAFs)? - Answer- Abundant cell types in the
tumor microenvironment that secrete tumor-promoting factors.
What is the role of the extracellular matrix (ECM) in the tumor microenvironment? -
Answer- It provides structural support and biochemical signals influencing tumor
proliferation.
What does TME stand for? - Answer- Tumor Microenvironment
What are the main components of the tumor microenvironment? - Answer- Cellular
components, extracellular components (ECM), and physical parameters (temperature,
interstitial pressure, pH, oxygen level).
