Absorption
the process by which drug molecules move from their site of administration to the blood
Affinity
the ability of some tissues to attract, accumulate and store drugs in high concentrations relative to other tissues
blood-brain barrier
Blood vessels (capillaries) that selectively let certain substances enter the brain tissue and keep other
substances out
diffusion
process by which molecules tend to move from an area where they are more concentrated to an area where
they are less concentrated
,distribution
the transport of drugs throughout the body after they are absorbed
drug-protein complexes
formed when a drugh that binds reversibly to a plasma protein, particularly albumin, that makes the drug
unavailable for distribution to its site of action
enterohepatic recirculation
recycling of drugs and other substances by the circulation of bile through the intestine and liver
enzyme induction
process by whick a drug increases the activity of the hepatic microsomal enzymes
excretion
the process of removing substances from the body
, first-pass effect
mechanism whereby drugs are absorbed enter into the hepatic portal circulation and are inactivated by the
liver before they reach the general circulation
fetal-placental barrier
special anatomic barrier that inhibits many chemicals and drugs from entering the fetus
hepatic microsomal enzyme system
as it relates to phamacotherapy, liver enzymes that metabolize drugs as well as nutrients and other endogenous
substances, sometimes called the P-450 System
isozymes
multiple similar forms of an enzyme that perform slightly different metabolic functions
loading dose
relatively large dose of a drug given at the beginning of treatment to rapidly obtain a therapeutic response
the process by which drug molecules move from their site of administration to the blood
Affinity
the ability of some tissues to attract, accumulate and store drugs in high concentrations relative to other tissues
blood-brain barrier
Blood vessels (capillaries) that selectively let certain substances enter the brain tissue and keep other
substances out
diffusion
process by which molecules tend to move from an area where they are more concentrated to an area where
they are less concentrated
,distribution
the transport of drugs throughout the body after they are absorbed
drug-protein complexes
formed when a drugh that binds reversibly to a plasma protein, particularly albumin, that makes the drug
unavailable for distribution to its site of action
enterohepatic recirculation
recycling of drugs and other substances by the circulation of bile through the intestine and liver
enzyme induction
process by whick a drug increases the activity of the hepatic microsomal enzymes
excretion
the process of removing substances from the body
, first-pass effect
mechanism whereby drugs are absorbed enter into the hepatic portal circulation and are inactivated by the
liver before they reach the general circulation
fetal-placental barrier
special anatomic barrier that inhibits many chemicals and drugs from entering the fetus
hepatic microsomal enzyme system
as it relates to phamacotherapy, liver enzymes that metabolize drugs as well as nutrients and other endogenous
substances, sometimes called the P-450 System
isozymes
multiple similar forms of an enzyme that perform slightly different metabolic functions
loading dose
relatively large dose of a drug given at the beginning of treatment to rapidly obtain a therapeutic response
