Examination – Full-Length Practice
Questions And Correct Answers (Verified
Answers) Plus Rationales 2026 Q&A
1. A patient with chronic low back pain has MRI findings of Modic
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type I changes at L4-L5. These changes most likely represent:
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A. Fatty marrow replacement
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B. Subchondral sclerosis ||
C. Active inflammatory endplate changes
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D. Disc calcification
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Answer: C ||
Modic type I changes reflect bone marrow edema and
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inflammation at the vertebral endplates, often associated with
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|| pain.
2. The primary mechanism of action of gabapentin in neuropathic pain is:
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A. Sodium channel blockade || ||
, B. NMDA receptor antagonism
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C. Binding to the alpha-2-delta subunit of voltage-gated
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calcium channels
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D. GABA-A receptor activation|| ||
Answer: C ||
Gabapentin decreases excitatory neurotransmitter release by
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|| modulating calcium channel function.
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3. Which nerve root is most commonly involved in a posterolateral
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L5-S1 disc herniation?
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A. L3
B. L4
C. L5
D. S1
Answer: D ||
Posterolateral herniations at L5-S1 typically compress the
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traversing S1 nerve root.
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4. The most appropriate initial treatment for postherpetic neuralgia in
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an elderly patient is:
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A. Oral corticosteroids
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B. Opioids
C. Topical lidocaine patch
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D. Benzodiazepines
Answer: C ||
, Topical lidocaine provides effective localized analgesia with minimal
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|| systemic effects. ||
5. Which spinal cord tract is primarily responsible for pain
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and temperature sensation?
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A. Dorsal columns ||
B. Corticospinal tract ||
C. Spinocerebellar tract ||
D. Spinothalamic tract ||
|| Answer: D ||
The spinothalamic tract transmits nociceptive and thermal sensory
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|| information.
6. A patient on long-term opioid therapy develops decreased
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analgesic effect requiring dose escalation. This phenomenon is
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best described as:
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A. Addiction
B. Pseudoaddiction
C. Tolerance
D. Physical dependence ||
Answer: C ||
Tolerance refers to reduced drug effect over time, requiring
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higher doses to achieve the same effect.
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7. Which medication is a mixed agonist-antagonist opioid?
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A. Morphine
, B. Fentanyl
C. Buprenorphine
D. Methadone
Answer: C ||
Buprenorphine is a partial mu-opioid receptor agonist with
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|| antagonist properties. ||
8. The recommended maximum daily dose of acetaminophen for
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most adults is:
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A. 2 grams
||
B. 3 grams
||
C. 4 grams
||
D. 6 grams
||
Answer: C ||
Exceeding 4 grams per day increases the risk of hepatotoxicity.
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9. Which structure is targeted in a stellate ganglion block?
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A. Cervical sympathetic chain at C2
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B. Cervicothoracic sympathetic ganglion near C6-C7 || || || ||
C. Vagus nerve ||
D. Phrenic nerve ||
Answer: B ||
The stellate ganglion lies near the C6-C7 vertebral level and is
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part of the cervical sympathetic chain.
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