Lehne’s Pharmacotherapeutics for Advanced
Practice Nurses
Most Tested Exam Questions – Examiner Marked Review
Question 1: A drug has a half-life of 10 hours. Approximately how
long will it take for the medication to reach steady-state plasma
levels with repeated dosing?
A. 10 hours
B. 20 hours
✓ C. 40–50 hours ← correct
D. 70 hours
Examiner’s Note: Most exams test that steady state occurs after ~4–5
half-lives.
Question 2: Which factor most significantly affects oral drug
bioavailability?
A. Drug color
✓ B. First-pass hepatic metabolism ← correct
C. Tablet shape
D. Injection technique
Examiner’s Note: Expect questions linking oral drugs with liver metabolism
reducing bioavailability.
Question 3: Which drug class is considered first-line therapy for
hypertension in many patients due to renal protective effects?
A. Beta blockers
✓ B. ACE inhibitors ← correct
C. Calcium channel blockers
D. Nitrates
Examiner’s Note: ACE inhibitors frequently tested for kidney protection
especially in diabetes.
Question 4: Which electrolyte imbalance is commonly associated with
loop diuretics?
A. Hyperkalemia
✓ B. Hypokalemia ← correct
C. Hypernatremia
D. Hypercalcemia
, Examiner’s Note: Loop diuretics cause potassium loss—very common
pharmacology exam point.
Question 5: Which antibiotic class works by inhibiting bacterial cell
wall synthesis?
✓ A. Penicillins ← correct
B. Macrolides
C. Tetracyclines
D. Fluoroquinolones
Examiner’s Note: Cell wall inhibition is a classic test concept for
beta■lactam antibiotics.
Question 6: A drug has a half-life of 10 hours. Approximately how
long will it take for the medication to reach steady-state plasma
levels with repeated dosing?
A. 10 hours
B. 20 hours
✓ C. 40–50 hours ← correct
D. 70 hours
Examiner’s Note: Most exams test that steady state occurs after ~4–5
half-lives.
Question 7: Which factor most significantly affects oral drug
bioavailability?
A. Drug color
✓ B. First-pass hepatic metabolism ← correct
C. Tablet shape
D. Injection technique
Examiner’s Note: Expect questions linking oral drugs with liver metabolism
reducing bioavailability.
Question 8: Which drug class is considered first-line therapy for
hypertension in many patients due to renal protective effects?
A. Beta blockers
✓ B. ACE inhibitors ← correct
C. Calcium channel blockers
D. Nitrates
Examiner’s Note: ACE inhibitors frequently tested for kidney protection
especially in diabetes.
Question 9: Which electrolyte imbalance is commonly associated with
loop diuretics?
, A. Hyperkalemia
✓ B. Hypokalemia ← correct
C. Hypernatremia
D. Hypercalcemia
Examiner’s Note: Loop diuretics cause potassium loss—very common
pharmacology exam point.
Question 10: Which antibiotic class works by inhibiting bacterial
cell wall synthesis?
✓ A. Penicillins ← correct
B. Macrolides
C. Tetracyclines
D. Fluoroquinolones
Examiner’s Note: Cell wall inhibition is a classic test concept for
beta■lactam antibiotics.
Question 11: A drug has a half-life of 10 hours. Approximately how
long will it take for the medication to reach steady-state plasma
levels with repeated dosing?
A. 10 hours
B. 20 hours
✓ C. 40–50 hours ← correct
D. 70 hours
Examiner’s Note: Most exams test that steady state occurs after ~4–5
half-lives.
Question 12: Which factor most significantly affects oral drug
bioavailability?
A. Drug color
✓ B. First-pass hepatic metabolism ← correct
C. Tablet shape
D. Injection technique
Examiner’s Note: Expect questions linking oral drugs with liver metabolism
reducing bioavailability.
Question 13: Which drug class is considered first-line therapy for
hypertension in many patients due to renal protective effects?
A. Beta blockers
✓ B. ACE inhibitors ← correct
C. Calcium channel blockers
D. Nitrates
, Examiner’s Note: ACE inhibitors frequently tested for kidney protection
especially in diabetes.
Question 14: Which electrolyte imbalance is commonly associated with
loop diuretics?
A. Hyperkalemia
✓ B. Hypokalemia ← correct
C. Hypernatremia
D. Hypercalcemia
Examiner’s Note: Loop diuretics cause potassium loss—very common
pharmacology exam point.
Question 15: Which antibiotic class works by inhibiting bacterial
cell wall synthesis?
✓ A. Penicillins ← correct
B. Macrolides
C. Tetracyclines
D. Fluoroquinolones
Examiner’s Note: Cell wall inhibition is a classic test concept for
beta■lactam antibiotics.
Question 16: A drug has a half-life of 10 hours. Approximately how
long will it take for the medication to reach steady-state plasma
levels with repeated dosing?
A. 10 hours
B. 20 hours
✓ C. 40–50 hours ← correct
D. 70 hours
Examiner’s Note: Most exams test that steady state occurs after ~4–5
half-lives.
Question 17: Which factor most significantly affects oral drug
bioavailability?
A. Drug color
✓ B. First-pass hepatic metabolism ← correct
C. Tablet shape
D. Injection technique
Examiner’s Note: Expect questions linking oral drugs with liver metabolism
reducing bioavailability.
Question 18: Which drug class is considered first-line therapy for
hypertension in many patients due to renal protective effects?
Practice Nurses
Most Tested Exam Questions – Examiner Marked Review
Question 1: A drug has a half-life of 10 hours. Approximately how
long will it take for the medication to reach steady-state plasma
levels with repeated dosing?
A. 10 hours
B. 20 hours
✓ C. 40–50 hours ← correct
D. 70 hours
Examiner’s Note: Most exams test that steady state occurs after ~4–5
half-lives.
Question 2: Which factor most significantly affects oral drug
bioavailability?
A. Drug color
✓ B. First-pass hepatic metabolism ← correct
C. Tablet shape
D. Injection technique
Examiner’s Note: Expect questions linking oral drugs with liver metabolism
reducing bioavailability.
Question 3: Which drug class is considered first-line therapy for
hypertension in many patients due to renal protective effects?
A. Beta blockers
✓ B. ACE inhibitors ← correct
C. Calcium channel blockers
D. Nitrates
Examiner’s Note: ACE inhibitors frequently tested for kidney protection
especially in diabetes.
Question 4: Which electrolyte imbalance is commonly associated with
loop diuretics?
A. Hyperkalemia
✓ B. Hypokalemia ← correct
C. Hypernatremia
D. Hypercalcemia
, Examiner’s Note: Loop diuretics cause potassium loss—very common
pharmacology exam point.
Question 5: Which antibiotic class works by inhibiting bacterial cell
wall synthesis?
✓ A. Penicillins ← correct
B. Macrolides
C. Tetracyclines
D. Fluoroquinolones
Examiner’s Note: Cell wall inhibition is a classic test concept for
beta■lactam antibiotics.
Question 6: A drug has a half-life of 10 hours. Approximately how
long will it take for the medication to reach steady-state plasma
levels with repeated dosing?
A. 10 hours
B. 20 hours
✓ C. 40–50 hours ← correct
D. 70 hours
Examiner’s Note: Most exams test that steady state occurs after ~4–5
half-lives.
Question 7: Which factor most significantly affects oral drug
bioavailability?
A. Drug color
✓ B. First-pass hepatic metabolism ← correct
C. Tablet shape
D. Injection technique
Examiner’s Note: Expect questions linking oral drugs with liver metabolism
reducing bioavailability.
Question 8: Which drug class is considered first-line therapy for
hypertension in many patients due to renal protective effects?
A. Beta blockers
✓ B. ACE inhibitors ← correct
C. Calcium channel blockers
D. Nitrates
Examiner’s Note: ACE inhibitors frequently tested for kidney protection
especially in diabetes.
Question 9: Which electrolyte imbalance is commonly associated with
loop diuretics?
, A. Hyperkalemia
✓ B. Hypokalemia ← correct
C. Hypernatremia
D. Hypercalcemia
Examiner’s Note: Loop diuretics cause potassium loss—very common
pharmacology exam point.
Question 10: Which antibiotic class works by inhibiting bacterial
cell wall synthesis?
✓ A. Penicillins ← correct
B. Macrolides
C. Tetracyclines
D. Fluoroquinolones
Examiner’s Note: Cell wall inhibition is a classic test concept for
beta■lactam antibiotics.
Question 11: A drug has a half-life of 10 hours. Approximately how
long will it take for the medication to reach steady-state plasma
levels with repeated dosing?
A. 10 hours
B. 20 hours
✓ C. 40–50 hours ← correct
D. 70 hours
Examiner’s Note: Most exams test that steady state occurs after ~4–5
half-lives.
Question 12: Which factor most significantly affects oral drug
bioavailability?
A. Drug color
✓ B. First-pass hepatic metabolism ← correct
C. Tablet shape
D. Injection technique
Examiner’s Note: Expect questions linking oral drugs with liver metabolism
reducing bioavailability.
Question 13: Which drug class is considered first-line therapy for
hypertension in many patients due to renal protective effects?
A. Beta blockers
✓ B. ACE inhibitors ← correct
C. Calcium channel blockers
D. Nitrates
, Examiner’s Note: ACE inhibitors frequently tested for kidney protection
especially in diabetes.
Question 14: Which electrolyte imbalance is commonly associated with
loop diuretics?
A. Hyperkalemia
✓ B. Hypokalemia ← correct
C. Hypernatremia
D. Hypercalcemia
Examiner’s Note: Loop diuretics cause potassium loss—very common
pharmacology exam point.
Question 15: Which antibiotic class works by inhibiting bacterial
cell wall synthesis?
✓ A. Penicillins ← correct
B. Macrolides
C. Tetracyclines
D. Fluoroquinolones
Examiner’s Note: Cell wall inhibition is a classic test concept for
beta■lactam antibiotics.
Question 16: A drug has a half-life of 10 hours. Approximately how
long will it take for the medication to reach steady-state plasma
levels with repeated dosing?
A. 10 hours
B. 20 hours
✓ C. 40–50 hours ← correct
D. 70 hours
Examiner’s Note: Most exams test that steady state occurs after ~4–5
half-lives.
Question 17: Which factor most significantly affects oral drug
bioavailability?
A. Drug color
✓ B. First-pass hepatic metabolism ← correct
C. Tablet shape
D. Injection technique
Examiner’s Note: Expect questions linking oral drugs with liver metabolism
reducing bioavailability.
Question 18: Which drug class is considered first-line therapy for
hypertension in many patients due to renal protective effects?
