Multiple Sclerosis is an ___ mediated, progressive ___ disease of the CNS that results in
impaired ___ ____ correct answers immune, demyelinating, nerve transmission
MS affects correct answers 20-40 year old women
in MS, _ ___ remain in the CNS and promote ___ of other ___ that damage the immune system
and lead to ____ and ____ of the myelin and ___ formation correct answers T Cells, infiltration,
agents, inflammation, demyelination, plaque
most common form; with each relapse, recovery is complete but residual deficits accumulate
over time correct answers relapsing-remitting
disease progression with or without relapses correct answers secondary progressive
disabling symptoms steadily increase with rare plateaus and temporary improvement correct
answers primary progressive
least common; relapses with continuous disabling progression between exacerbations correct
answers progressive relapsing
diagnostic tests for MS (4) correct answers exam
MRI
EPS (evoked potential studies)
CSF (identifies presence of oligoclonal banding)
disease-modifying meds correct answers A - Avonex (IM once per week) OR Rebif (SQ 3 times
per week)
, B - Betaseron (SQ every other day)
C - Copaxone (SQ daily)
disease-modifying med goals (3) correct answers decrease frequency of relapse
decrease duration of relapse
decrease plaques on MRI
BRM side effects (5) correct answers flu-like - take at night
depression/suicidal tendencies/anxiety
leukopenia/thrombocytopenia
elevated liver enzymes
hypersensitivity at injection site
copaxone side effect correct answers transient chest pain
things to monitor when on BRMs (4) correct answers liver enzymes
CBC/platelets
injection site
emotional changes
cytoxan and methotrexate are ___ agents correct answers antineoplastic
immuran and sandimmune are ____ drugs correct answers immunosuppressant
anticonvulsant drug for spasticity correct answers klonopin