BCL-2 Family Proteins – 2026 – Study Guide and Review
Material
activator BH3 only function - correct answer ✔✔ induces conformational changes in BAK/BAX
that leads to MOMP
multidomain pro-apoptotic function - correct answer ✔✔ induce apoptosis by generating pores
in the outer mitochondrial membrane, causing MOMP
sensitizer BH3 only function - correct answer ✔✔ sequester anti-apoptotic proteins, acting as
"inhibitors of inhibitors", allowing for the release of activators and activated BAK/BAX
multidomain anti-apoptotic function - correct answer ✔✔ these proteins inhibit activator BH3
only proteins, preventing conformational changes in pore-formers and hindering MOMP
BID - correct answer ✔✔ activator BH3 only
BIM - correct answer ✔✔ activator BH3 only
BAD - correct answer ✔✔ sensitizer BH3 only
BIK - correct answer ✔✔ sensitizer BH3 only
NOXA - correct answer ✔✔ sensitizer BH3 only
HRK - correct answer ✔✔ sensitizer BH3 only
Material
activator BH3 only function - correct answer ✔✔ induces conformational changes in BAK/BAX
that leads to MOMP
multidomain pro-apoptotic function - correct answer ✔✔ induce apoptosis by generating pores
in the outer mitochondrial membrane, causing MOMP
sensitizer BH3 only function - correct answer ✔✔ sequester anti-apoptotic proteins, acting as
"inhibitors of inhibitors", allowing for the release of activators and activated BAK/BAX
multidomain anti-apoptotic function - correct answer ✔✔ these proteins inhibit activator BH3
only proteins, preventing conformational changes in pore-formers and hindering MOMP
BID - correct answer ✔✔ activator BH3 only
BIM - correct answer ✔✔ activator BH3 only
BAD - correct answer ✔✔ sensitizer BH3 only
BIK - correct answer ✔✔ sensitizer BH3 only
NOXA - correct answer ✔✔ sensitizer BH3 only
HRK - correct answer ✔✔ sensitizer BH3 only
