Haemolytic Anaemia (Week 2)– Questions With
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Terms in this set (36)
What is definition of haemolytic Hemolytic anemia is a disorder in which red blood
anaemia? cells are destroyed faster than they can be made.
The destruction of red blood cells is called
hemolysis.
Describe haemolytic anaemia? -Erythrocyte count and haemoglobin concentration
in peripheral blood represents an equilibrium
between:
-Production of red blood cells
-Destruction of red blood cells
-Haemolytic anaemia results from an increase in the
rate of red cell destruction
-May result in compensated or non-compensated
haemolysis
What is compensated and non -Normally the bone marrow is working below its
compensated haemolysis? maximum capacity
-Can increase red cell production 6-8 fold if
necessary
-Increase rate of red cell destruction may therefore
be matched by increase rate of red cell production
-"compensated haemolysis'
-If the rate of red cell destruction exceeds capacity
of the bone marrow to compensate
-"Non compensated haemolysis"
-"haemolytic anaemia
, Compare the red blood cell life span -Normal red blood cell life span 120 days
compared to anaemia? -Reduction of life span 20-30 days :
-Bone marrow able to compensate
-Provide supply of iron, vitamin B12 and folate is
sufficient
-Reduction of life span to 5-10 days or less
-anaemia occurs
-leads to marked reticulocytosis
-Particularly in more anaemic cases
Describe the functions of normal -Main role is to transport of oxygen to tissue and
erythrocytes? CO2 from tissues
-Shape bioconcave disc
-Promotes deformability
-Cell diameter 8um
-Capillary diameter 3.5 um
-High surface area; volume ratio
-Volume, 90 fL; SA-140mm2
-Minimum SA required for spherical shape -98mm2
-1.5x SA actually needed
-Good for gaseous exchange
-Maintained by membrane associated cytoskeleton
Describe the membrane associated -Red cell membrane
cytoskeleton? -Consists of a lipid bilayer containing a number of
proteins:
-Transmembrane proteins
-Surface proteins
-Red cell membrane is tightly connected with a
network of proteins at the cytoplasmic interface the
cytoskeleton
-Horizontal and vertical interactions
Appropriate Solutions
Save
Terms in this set (36)
What is definition of haemolytic Hemolytic anemia is a disorder in which red blood
anaemia? cells are destroyed faster than they can be made.
The destruction of red blood cells is called
hemolysis.
Describe haemolytic anaemia? -Erythrocyte count and haemoglobin concentration
in peripheral blood represents an equilibrium
between:
-Production of red blood cells
-Destruction of red blood cells
-Haemolytic anaemia results from an increase in the
rate of red cell destruction
-May result in compensated or non-compensated
haemolysis
What is compensated and non -Normally the bone marrow is working below its
compensated haemolysis? maximum capacity
-Can increase red cell production 6-8 fold if
necessary
-Increase rate of red cell destruction may therefore
be matched by increase rate of red cell production
-"compensated haemolysis'
-If the rate of red cell destruction exceeds capacity
of the bone marrow to compensate
-"Non compensated haemolysis"
-"haemolytic anaemia
, Compare the red blood cell life span -Normal red blood cell life span 120 days
compared to anaemia? -Reduction of life span 20-30 days :
-Bone marrow able to compensate
-Provide supply of iron, vitamin B12 and folate is
sufficient
-Reduction of life span to 5-10 days or less
-anaemia occurs
-leads to marked reticulocytosis
-Particularly in more anaemic cases
Describe the functions of normal -Main role is to transport of oxygen to tissue and
erythrocytes? CO2 from tissues
-Shape bioconcave disc
-Promotes deformability
-Cell diameter 8um
-Capillary diameter 3.5 um
-High surface area; volume ratio
-Volume, 90 fL; SA-140mm2
-Minimum SA required for spherical shape -98mm2
-1.5x SA actually needed
-Good for gaseous exchange
-Maintained by membrane associated cytoskeleton
Describe the membrane associated -Red cell membrane
cytoskeleton? -Consists of a lipid bilayer containing a number of
proteins:
-Transmembrane proteins
-Surface proteins
-Red cell membrane is tightly connected with a
network of proteins at the cytoplasmic interface the
cytoskeleton
-Horizontal and vertical interactions
