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A powerful study resource designed to support exam success and boost confidence.
What happens to nerve tissue during ischemia? ------- ✔ CORRECT ANSWER ✓✓Nerve tissue
struggles with anaerobic metabolism and is very sensitive to decreased oxygen.
What is ischemia? ------- ✔ CORRECT ANSWER ✓✓Cell death.
What is hypoxia? ------- ✔ CORRECT ANSWER ✓✓Decreased oxygen leading to mitochondrial
failure and cell damage.
What is the main CNS neurotransmitter? ------- ✔ CORRECT ANSWER ✓✓Glutamate.
What effect does ischemia have on glutamate? ------- ✔ CORRECT ANSWER ✓✓Ischemia
increases glutamate release.
What are the effects of too much glutamate? ------- ✔ CORRECT ANSWER ✓✓Increased calcium
and water enter the cell, causing calcium overload and cytotoxic edema.
What does excessive glutamate production lead to? ------- ✔ CORRECT ANSWER ✓✓Increased
production of nitrous oxide, free radical formation, and cell death.
What is the normal range for intracranial pressure (ICP)? ------- ✔ CORRECT ANSWER ✓✓0-15
mmHg
,At what ICP level does brain impairment occur? ------- ✔ CORRECT ANSWER ✓✓> 22 mmHg for
> 5 minutes
What are the three main components of the cranial cavity according to the Monroe-Kellie
doctrine? ------- ✔ CORRECT ANSWER ✓✓Brain, Cerebrospinal Fluid (CSF), Blood
What is intracranial compliance? ------- ✔ CORRECT ANSWER ✓✓The ability of the cranial
components to adjust to changes in volume to minimize impact on ICP.
Name an everyday activity that can cause slight changes in ICP. ------- ✔ CORRECT ANSWER
✓✓Sneeze, cough, bending, laugh
What is interstitial edema? ------- ✔ CORRECT ANSWER ✓✓Swelling caused by fluid,
electrolytes, and proteins forced into the intercellular space due to vessel damage or increased
pressure.
What causes intracellular edema? ------- ✔ CORRECT ANSWER ✓✓Global ischemia leading to
cellular energy failure and Na+ accumulation, attracting water into the cell.
What is the most sensitive clinical manifestation of increased ICP? ------- ✔ CORRECT ANSWER
✓✓Change in level of consciousness (LOC), often increased drowsiness.
What are common symptoms of increased ICP? ------- ✔ CORRECT ANSWER ✓✓Headache,
nausea/vomiting, blurred vision, slow pupillary response.
What is Cushing's Triad? ------- ✔ CORRECT ANSWER ✓✓A late sign of increased ICP
characterized by ↑BP, ↓HR, and respiratory changes.
, What does a decrease in the Glasgow Coma Scale (GCS) score indicate? ------- ✔ CORRECT
ANSWER ✓✓A potential decrease in consciousness or brain function.
What is the maximum score for eye opening on the Glasgow Coma Scale? ------- ✔ CORRECT
ANSWER ✓✓4 for spontaneous eye opening.
What is the maximum score for verbal response on the Glasgow Coma Scale? ------- ✔ CORRECT
ANSWER ✓✓5 for oriented verbal response.
What is the maximum score for motor response on the Glasgow Coma Scale? ------- ✔ CORRECT
ANSWER ✓✓6 for following commands.
What does decreased pupil response indicate? ------- ✔ CORRECT ANSWER ✓✓Increased
intracranial pressure (ICP).
What is the normal response in the Doll's Eyes Test? ------- ✔ CORRECT ANSWER ✓✓Eyes move
in the opposite direction of head movement.
What does an absent response in the Cold Calorics test indicate? ------- ✔ CORRECT ANSWER
✓✓No eye movement, suggesting potential brain dysfunction.
What is the normal response of the corneal reflex? ------- ✔ CORRECT ANSWER ✓✓Blinking
when a cotton swab touches the cornea.
What does fixed and dilated pupils indicate? ------- ✔ CORRECT ANSWER ✓✓Poor brain
perfusion.