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Rheumatology 1 ClinMed Rheum Ortho – Latest Version Exam Review with Complete Questions & Correct Detailed Answers (Medicine)

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Rheumatology 1 ClinMed Rheum Ortho – Latest Version Exam Review with Complete Questions & Correct Detailed Answers (Medicine)

Institution
Rheumatology
Course
Rheumatology

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POLYMYALGIA RHEUMATICA -ANSWER an inflammatory disorder of the muscles and
joints characterized by pain and stiffness in the neck, shoulders, upper arms, and hips and
thighs



note that it is immune mediated and often affects women over 50



strong associated with GCA - they share the same demographic



MUSCLE PAIN & STIFFNESS



What group of people does PMR typically effect? -ANSWER women aged over 50



Describe the pathophysiology of PMR -ANSWER Antibodies which are produced by the
autoimmune response enter circulation where they travel to muscles and joints, macrophages
go to these joints and secrete inflammatory cytokines eg TNF-alpha, IL-1, IL-6 which promote
inflammation of joint causing pain



Histology shows vasculitis with giant cells which skip certain sections of affected artery



Describe how PMR typically presents -ANSWER Rapid onset - less than 2 weeks



MORNING STIFFNESS and bilateral aching

,- systemic symptoms: fatigue, low grade fever, anorexia,d depression, lethargy, night sweats



Is the aching in PMR unilateral of bilateral? -ANSWER BILATERAL



- shoulders

- hips

- proximal limb muscles



Describe the pain/stiffness associated with PMR -ANSWER More severe in morning and
at night



Last longer than an hour



Gets better with activity



What other inflammatory conditions may be associated with PMR? -ANSWER Mild
polyartehritis



Tensosynvitis



Carpel tunnel syndrome



Temporal arthritis - headache, blindess



What is the key diagnostic feature of PMR? -ANSWER EVELATED ESR

, CRP may be normal



Describe what bloods you would do when diagnosing PMR -ANSWER - FBC: elevated ESR,
CRP may be normal

- LFTs: elevated ALP in 30% of patients

- CK: normal to differentiate between myositis and myopathies, little muscle damage



Give some differential diagnosis of PCA -ANSWER - Recent onset RA

- Polymyositis

- Hypothyroidism

- Primary muscle disease

- OA especially cervical spondylosis and shoulder OA

- Neck lesions

- Spinal stenosis



What is the basic management of PMR? -ANSWER PREDNISIOLONE, 15mg - NSAIDS are
not effective. most patientsbeed steroids for more than 2 years, methotrexate for relapse



Dramatic response within 1 week and if this is not the case then consider another diagnosis



Consider bone protection due to steroids



Are NSAIDs effective at treating PMA? -ANSWER No - prednisolone



What is ESR? -ANSWER Erythrocyte Sedimentation Rate

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Institution
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