Anemia, Pernicious Anemia, Folic Acid Deficiency, Aplastic Anemia, Sickle Cell
Anemia, Polycythemia, Leukemia, Lymphoma, Hemostasis, Thrombocytopenia,
Immune Thrombocytopenic Purpura, Heparin-Induced Thrombocytopenia,
Hemophilia A, Hemophilia B, von Willebrand Disease, Disseminated
Intravascular Coagulation, Neutropenia, Blood Typing, ABO System, Rh Factor,
Rhogam, Packed RBCs, Platelets, Fresh Frozen Plasma, Cryoprecipitates,
Albumin, Transfusion Reactions, Transfusion Guidelines Exam Questions
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What are three common blood products?
Albumin
Cryoprecipitates and Commercial Concentrates
Fresh Frozen Plasma
Frozen RBCs
Packed RBCs
Platelets
How does albumin increase fluid volume?
Albumin 25% expands the blood volume by 3.5 times.
Hyperosmolar solution acts by moving water from extravascular to intravascular space.
What is albumin used for?
Hypovolemic shock, hypoalbuminemia, after large-volume paracentesis, replacement in plasmapheresis.
What are cryoprecipitates and commercial concentrates used for?
, Replacement for fibrinogen deficiency, usually due to DIC, severe liver disease, or massive transfusion.
Has other clotting factors, especially factor VIII, factor XIII, and von Willebrand factor.
What is fresh frozen plasma used for?
Bleeding caused by deficiency in clotting factors (e.g., DIC, bleeding, massive transfusion, liver disease,
vitamin K deficiency, excess warfarin).
What are packed RBCs used for?
Severe or symptomatic anemia, acute blood loss. 1 unit of RBCs can be expected to increase hemoglobin
by 1 g/dL or hematocrit by 3% in a typical adult.
One unit can replace a blood loss of 500 mL.
What are some advantages of giving packed RBCs?
Use of RBCs for treatment allows remaining components of blood (e.g., platelets, albumin, plasma) to be
used for other purposes.
Less risk of fluid overload.
What are platelets used for?
Bleeding caused by thrombocytopenia.
ABO Blood Typing System
The presence or absence of antigens is the basis for the 4 blood groups (A, B, AB, O).
Blood group A has _______ antigens.