| UPDATED 2026
nocicep ve
Ini ated by nociceptors ac vated by injury to peripheral ssue and representa ve of the normal
pain process
Transduc on
The ac va on of pain receptors involving the conversion of painful s muli into electrical
impulses traveling from periphery to spinal cord at the dorsal horn
Lac c acid
________ accumulates where there's a lack of blood supply and excites nerve endings
Bradykinin
a powerful vasodilator that increases capillary permeability and constricts smooth muscle. It
also triggers the release of histamine
Prostaglandins
Important hormone like substances that send addi onal painful s muli to the CNS
Substance p
Sensi zes receptors on nerves to feel pain and also increases the rate of firing of nerves
Health history
This part of the health assessment includes biographical data, reason for seeking healthcare,
history of present health concern, past health history and family history, func onal health
assessment, psychosocial and lifestyle factors, and reviews of systems
Subjec ve
Is the health history objec ve or subjec ve?
Physical assessment
This assessment includes preparing, posi oning, inspec on, palpa on, percussion, and
ausculta on,
Pharmacokine cs
,This includes absorp on, distribu on, metabolism, and excre on
Pharmacodynamics
The process by which drugs act on target cells resul ng in altera ons in cellular reac ons
Idiosyncra c
This type of adverse drug reac on causes any unusual response that manifests itself by over
response/under response or the opposite expected response
Addi ve
This type of drug interac on is when two drugs with similar effects increase the overall effect
synergis c
This type of drug interac on is when drugs with different sites results in increased effects when
taking together
Antagonis c
This type of drug interac on is when two drugs negate each other
Interference
This type of drug interac on is when one drug interferes with metabolism of another drug
leading to medica on build up
Displacement
This type of drug interac on is when one drug binds causing the second drug to be displaced
and causes an increased affect of unbound drug
Pharmacogene cs
This is the differences in responses of pa ents receiving the same medica ons resul ng in
gene c differences
Medica on order
The seven parts of a ________________ are the name and date of a pa ent, date and me the
order was wri0en, name of the drug being administered, dosage of drug, route, frequency,
signature of the prescriber
Transmission
, Pain sensa ons from the site of an injury or inflamma on are conducted along pathways to the
spinal cord and then on to the high centers
Protec ve pain reflex
This is responsible for withdrawal of an endangered ssue from a damaging s mulus
Percep on
__________ of pain involves the sensory process that occurs when a s mulus for pain is present
and includes the persons interpreta on of the pain
Modula on
_________ of pain is the process by which the sensa on of pain is inhibited or modified by
Neuromodulators
Neuromodulators
endogenous opioid compounds, meaning they are naturally present, morphine-like chemical
regulators in the spinal cord and brain
Endorphins
"morphine within"--natural, opiatelike neurotransmi0ers linked to pain control and to pleasure.
They are powerful pain blocking chemicals that have prolonged and analgesic effects and
produce euphoria
Dynorphin
Which endorphin has the most potent analgesic effect?
Enkephalins
These are thought to reduce pain sensa ons by inhibi ng the release of substance P from the
terminals to afferent neurons
Gate control
The ______ ________ theory states that small nerve fibers conduct excitatory pain s muli
toward the brain, exaggera ng the effect of the arriving impulses through posi ve feedback
mechanism. And large nerve fibers appear to inhibit the transmission of pain impulses from the
spinal cord to the brain through nega ve feedback system.
Acute