CHEM 1005 FINAL WITH COMPLETE SOLUTIONS
GUARANTEED PASS 2025/2026
Which of the following best describes the role of HDL particles? -
ANSWER ->HDL particles are required for the transport of cholesterol
from peripheral tissues to the liver
Which lipoprotein is responsible for the process of reverse cholesterol
transport (the movement of cholesterol from the peripheral tissues
back to the liver)? - ANSWER ->HDL
VLDL particles have which of the following combinations of apoproteins
in their mature form? - ANSWER ->ApoB100,
ApoCII, ApoE
Which of the following proteins is responsible for the transfer of
ApoB48 to nascent chylomicrons before secretion into circulation? -
ANSWER ->Microsomal transfer protein (MTP)
A deficiency in the LDL receptor will result in an initial decrease in which
of the following? - ANSWER ->Intracellular cholesterol
Under cellular conditions when cholesterol is low, which of the
following is a true statement regarding the sterol response element
binding protein? - ANSWER ->It will be associated with the sterol
response element (SRE) in the DNA
The cellular uptake of LDL increases intracellular cholesterol levels. This
has which of the following impacts on de novo cholesterol synthesis? -
ANSWER ->Increases degradation of
,HMG-CoA reductase
The LDL receptor is also highly regulated in the cell. Which of the
following proteins targets the LDL receptor for degradation? - ANSWER
->Proprotein convertase
subtilisin/kexin type 9 (PSK9)
Bile salts are synthesized from cholesterol and are used for the
emulsification of dietary lipids. What is the primary fate of bile salts
during digestion? - ANSWER ->They are reabsorbed in the ileum
A 45-year-old man has a mild heart attack and a history of vascular
disease. He is placed on a Mediterranean diet and statin drug therapy.
Which of the following will be the most likely result of this drug
therapy? - ANSWER ->Low blood LDLs
When an LDL particle is taken up by the cell, what impact will this have
on the regulation of de novo cholesterol synthesis? - ANSWER ->SREBP
will be inhibited by Insig in the endoplasmic reticulum
Which of the following compounds is not synthesized from cholesterol?
- ANSWER ->Guanine
A comatose infant is brought to the ER. In the course of the
examination, plasma ammonia was found to be elevated 20fold over
normal values. Urine orotic acid and uracil were both greater than
normal. A defect of which of the following enzymes is the most likely
diagnosis? - ANSWER ->Ornithine transcarbamoylase
Which of the following reactions of the urea cycle takes place in the
mitochondria? - ANSWER ->The synthesis of carbamoyl phosphate
, A deficiency in which of the following enzymes will not result in an
increase in orotic acid? - ANSWER ->N-acetyl glutamate synthetase
Which of the following is the primary role of glutaminase in the liver? -
ANSWER ->To free an amine group from glutamine Which of the
following enzymes is regulated by Nacetyl glutamate (NAGs)? -
ANSWER ->Carbamoyl phosphate synthetase I (CPS I)
The transamination of all amino acids requires which of the following
cofactors? - ANSWER ->Pyridoxal phosphate (PLP)
Which of the following urea cycle enzymes catalyzes the
reaction hydrolyzing the release of urea from arginine? - ANSWER -
>Arginase
Which of the following enzymes is likely to be active in both the fed and
fasted states? - ANSWER ->Glutaminase
Which of the following best describes the process of transamination? -
ANSWER ->The transfer of an amino group from an amino acid to a
keto-acid.
A 17-year old female presents to her primary care and is diagnosed with
a Vitamin B12 (cobalamin) deficiency. In this individual, which of the
following reactions would be compromised? - ANSWER ->Conversion of
methyl malonyl-Co A to succinyl-CoA
A 15-year-old female presents to her pediatrician with concerns over
her inability to sleep, increased feelings of depression and generalized
fatigue. A full laboratory work-up is ordered and based on these
GUARANTEED PASS 2025/2026
Which of the following best describes the role of HDL particles? -
ANSWER ->HDL particles are required for the transport of cholesterol
from peripheral tissues to the liver
Which lipoprotein is responsible for the process of reverse cholesterol
transport (the movement of cholesterol from the peripheral tissues
back to the liver)? - ANSWER ->HDL
VLDL particles have which of the following combinations of apoproteins
in their mature form? - ANSWER ->ApoB100,
ApoCII, ApoE
Which of the following proteins is responsible for the transfer of
ApoB48 to nascent chylomicrons before secretion into circulation? -
ANSWER ->Microsomal transfer protein (MTP)
A deficiency in the LDL receptor will result in an initial decrease in which
of the following? - ANSWER ->Intracellular cholesterol
Under cellular conditions when cholesterol is low, which of the
following is a true statement regarding the sterol response element
binding protein? - ANSWER ->It will be associated with the sterol
response element (SRE) in the DNA
The cellular uptake of LDL increases intracellular cholesterol levels. This
has which of the following impacts on de novo cholesterol synthesis? -
ANSWER ->Increases degradation of
,HMG-CoA reductase
The LDL receptor is also highly regulated in the cell. Which of the
following proteins targets the LDL receptor for degradation? - ANSWER
->Proprotein convertase
subtilisin/kexin type 9 (PSK9)
Bile salts are synthesized from cholesterol and are used for the
emulsification of dietary lipids. What is the primary fate of bile salts
during digestion? - ANSWER ->They are reabsorbed in the ileum
A 45-year-old man has a mild heart attack and a history of vascular
disease. He is placed on a Mediterranean diet and statin drug therapy.
Which of the following will be the most likely result of this drug
therapy? - ANSWER ->Low blood LDLs
When an LDL particle is taken up by the cell, what impact will this have
on the regulation of de novo cholesterol synthesis? - ANSWER ->SREBP
will be inhibited by Insig in the endoplasmic reticulum
Which of the following compounds is not synthesized from cholesterol?
- ANSWER ->Guanine
A comatose infant is brought to the ER. In the course of the
examination, plasma ammonia was found to be elevated 20fold over
normal values. Urine orotic acid and uracil were both greater than
normal. A defect of which of the following enzymes is the most likely
diagnosis? - ANSWER ->Ornithine transcarbamoylase
Which of the following reactions of the urea cycle takes place in the
mitochondria? - ANSWER ->The synthesis of carbamoyl phosphate
, A deficiency in which of the following enzymes will not result in an
increase in orotic acid? - ANSWER ->N-acetyl glutamate synthetase
Which of the following is the primary role of glutaminase in the liver? -
ANSWER ->To free an amine group from glutamine Which of the
following enzymes is regulated by Nacetyl glutamate (NAGs)? -
ANSWER ->Carbamoyl phosphate synthetase I (CPS I)
The transamination of all amino acids requires which of the following
cofactors? - ANSWER ->Pyridoxal phosphate (PLP)
Which of the following urea cycle enzymes catalyzes the
reaction hydrolyzing the release of urea from arginine? - ANSWER -
>Arginase
Which of the following enzymes is likely to be active in both the fed and
fasted states? - ANSWER ->Glutaminase
Which of the following best describes the process of transamination? -
ANSWER ->The transfer of an amino group from an amino acid to a
keto-acid.
A 17-year old female presents to her primary care and is diagnosed with
a Vitamin B12 (cobalamin) deficiency. In this individual, which of the
following reactions would be compromised? - ANSWER ->Conversion of
methyl malonyl-Co A to succinyl-CoA
A 15-year-old female presents to her pediatrician with concerns over
her inability to sleep, increased feelings of depression and generalized
fatigue. A full laboratory work-up is ordered and based on these
