This document contains exam-style questions and verified answers covering the contraindications, warnings, and mechanisms of action of immunoglobulin (Ig) therapy. It reviews major safety concerns including renal dysfunction, thrombotic events, aseptic meningitis, hemolytic anemia, and pulmonary complications associated with Ig products. The material also explains the therapeutic mechanisms of Ig therapy in both immunodeficiency replacement therapy and autoimmune disease treatment, including modulation of antibodies, complement inhibition, and cytokine regulation. Keywords: immunoglobulin contraindications IVIG warnings precautions renal dysfunction IVIG thrombotic events immunoglobulin aseptic meningitis IVIG hemolytic anemia immunoglobulin TRALI transfusion reaction hyperproteinemia IVIG increased serum viscosity immunoglobulin hyponatremia IVIG therapy Octagam maltose glucose monitoring immunoglobulin mechanism of action autoimmune immunoglobulin therapy complement inhibition IVIG cytokine modulation immunoglobulin
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