Health across the Lifespan Practicum - Chamberlain
, NR 547 Week 5
1. Medications for depression: SSRIs
SNRIs
SDRIs
TCAs
MAOIs
2. SSRIs: -Action: inhibit 5-HT reuptake
-Examples: citalopram, escitalopram, fluoxetine, paroxetine, sertraline
-Adverse effects:
• nausea
• agitation
• diarrhea
• headache
• weight gain
• sexual side effects
3. SNRIs: -inhibit 5-HT reuptake
-inhibit NE reuptake (‘ energy, focus)
-increase DA in prefrontal cortex (‘ cognition)
,-Examples: desvenlafaxine, duloxetine, levomilnacipran, venlafaxine
-Adverse effects:
• elevated blood pressure
• nausea
• sweating
• tremors
• anxiety
• insomnia
• constipation
• anorexia
• sexual dysfunction
4. SDRIs: -inhibit DA reuptake (‘alertness, motivation)
-inhibit NE reuptake (‘energy)
-Adverse effects:
• agitation
• headache
• dry mouth
• constipation
• weight loss
5. TCAs: -Action: inhibits the reuptake of serotonin and norepinephrine;
, blocks norepinephrine, histamine, and acetylcholine receptors
-Examples: amitriptyline, clomipramine, desipramine, doxepin
-Common Side Effects:
• dry mouth
• constipation
• blurred vision
• urinary retention
• sedation
• weight gain
• hypotension
• tachycardia
• sexual dysfunction
6. MAOIs: -Action: increases norepinephrine and serotonin by inhibiting the
enzyme that inactivates it
-Examples: isocarboxazid, phenelzine, tranylcypromine
-Common Side Effects:
• sedation
• dizziness
• sexual dysfunction