Immunology Assessment: Central and Peripheral Tolerance, Clonal Deletion,
Clonal Anergy, Clonal Editing, Autoreactive T and B Cells, Tolerogens, Apoptosis,
Immune Privilege, Autoimmune Diseases, Hashimoto’s Thyroiditis, Type 1
Diabetes, Myasthenia Gravis, Systemic Lupus Erythematosus, Multiple Sclerosis,
Rheumatoid Arthritis, HLA-B27, Genetic Susceptibility, Antigen-Specific
Immunotherapy, Graft Rejection, Autografts, Isografts, Allografts, Minor and
Major Histocompatibility Loci, ABO Blood Group Matching, T-cell Sensitization,
Effector Phase, CD4+ and CD8+ T Cells, Immunosuppressive Therapy,
Immunological Memory, and T-cell Deficient Models Exam Questions Verified
and Provided with Complete A+ Graded Rationales Latest Updated 2026
1. Central tolerance:
A. is the first step of tolerance mechanisms.
B. affects both T cells and B cells.
C. deletes cells that are autoreactive.
D. occurs in the bone marrow and thymus.
E. All of the above.
Answer: E
Section: Establishment and Maintenance of Tolerance
Difficulty: 1
Hint: Autoreactivity can involve both T cells and B cells.
2. Which of the following statements does NOT describe tolerogens accurately?
, A. They can be the same molecules as immunogens.
B. They lead cells to become unresponsive.
C. They are part of peripheral tolerance.
D. They only affect B cells.
E. All of the above.
Answer: D
Section: Establishment and Maintenance of Tolerance
Difficulty: 2
Hint: Tolerogens are equivalent to immunogens, but in different context.
3. The tolerogenic response:
A. is not antigen specific.
B. leads to apoptosis but not anergy.
C. results in cells becoming non-responsive.
D. depends of the presentation context.
E. affects T cells only.
Answer: C
Section: Establishment and Maintenance of Tolerance
Difficulty: 2
Hint: Anergy and apoptosis are both mechanisms of tolerance.
4. Tolerance is promoted by all of the following circumstances EXCEPT:
Clonal Anergy, Clonal Editing, Autoreactive T and B Cells, Tolerogens, Apoptosis,
Immune Privilege, Autoimmune Diseases, Hashimoto’s Thyroiditis, Type 1
Diabetes, Myasthenia Gravis, Systemic Lupus Erythematosus, Multiple Sclerosis,
Rheumatoid Arthritis, HLA-B27, Genetic Susceptibility, Antigen-Specific
Immunotherapy, Graft Rejection, Autografts, Isografts, Allografts, Minor and
Major Histocompatibility Loci, ABO Blood Group Matching, T-cell Sensitization,
Effector Phase, CD4+ and CD8+ T Cells, Immunosuppressive Therapy,
Immunological Memory, and T-cell Deficient Models Exam Questions Verified
and Provided with Complete A+ Graded Rationales Latest Updated 2026
1. Central tolerance:
A. is the first step of tolerance mechanisms.
B. affects both T cells and B cells.
C. deletes cells that are autoreactive.
D. occurs in the bone marrow and thymus.
E. All of the above.
Answer: E
Section: Establishment and Maintenance of Tolerance
Difficulty: 1
Hint: Autoreactivity can involve both T cells and B cells.
2. Which of the following statements does NOT describe tolerogens accurately?
, A. They can be the same molecules as immunogens.
B. They lead cells to become unresponsive.
C. They are part of peripheral tolerance.
D. They only affect B cells.
E. All of the above.
Answer: D
Section: Establishment and Maintenance of Tolerance
Difficulty: 2
Hint: Tolerogens are equivalent to immunogens, but in different context.
3. The tolerogenic response:
A. is not antigen specific.
B. leads to apoptosis but not anergy.
C. results in cells becoming non-responsive.
D. depends of the presentation context.
E. affects T cells only.
Answer: C
Section: Establishment and Maintenance of Tolerance
Difficulty: 2
Hint: Anergy and apoptosis are both mechanisms of tolerance.
4. Tolerance is promoted by all of the following circumstances EXCEPT:
