NUR 635 Advanced Pharmacology
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Pharmacology - CORRECT ANSWERthe study of drugs and their structure, targets of action,
mechanisms of action (MOA), distribution (how the body disburses them throughout the body),
desired physiologic effects (efficacy) and undesirable side effects (toxicity).
Pharmacokinetics includes the following: - CORRECT ANSWERADME (absorption, distribution,
metabolism and elimination).
Pharmacokinetics is... - CORRECT ANSWERHow the body effects the drug
Absorption - CORRECT ANSWERabsorption from the administration site either directly or
indirectly into the blood/plasma.
Distribution - CORRECT ANSWERreversibly/irreversibly movement of drug from the
bloodstream into the interstitial and intracellular fluid.
,Metabolism - CORRECT ANSWERdrug biotransformation via metabolic pathways, primarily the
liver, or by other tissues.
Elimination - CORRECT ANSWERhow parent drug & its metabolites are eliminated from the
body
Absorption factors - CORRECT ANSWER· Gastrointestinal pH changes
· Gastric emptying
· Gastric/intestinal enzymes
· Bile acids & biliary function
· Gastrointestinal flora (type and quantity of bacteria)
· Food & nutrient interactions (most common interaction influencing GI drug absorption)
· Lipid solubility of the drug
Distribution factors - CORRECT ANSWER· Membrane permeability: Cross membranes to site of
action
· Blood brain barrier reduces the speed of drug passage into and out of brain tissue
· Plasma protein binding: drugs bound to plasma proteins do not cross membranes (Note:
Malnutrition = âalbumin = á free drug = greater pharmacologic response)
· Aging cause a reduction in production of plasma proteins
· Lipophilicity of drug: lipophilic drugs concentrate in adipose tissue; remain in the body for a
longer period of time
Volume of distribution - CORRECT ANSWER· Body Composition
- Increased Total body water and extracellular fluid
-Decreased Adipose tissue and skeletal muscle
· Protein Binding (changes with aging)
,-Albumin, bilirubin, a1-acid glycoprotein
-Albumin affected by nutrition
-Low albumin (hypoalbuminemia) can cause less protein-bound drug reaching the tissue site of
action.
· Tissue Binding
- Compositional changes
Metabolism factors - CORRECT ANSWERo Drugs can undergo metabolism in the lungs, blood,
liver, intestines and kidney
o Volatile drugs are primarily excreted by the lungs
· The body changes drugs to more or less active forms (metabolites), increases water solubility
to increase elimination.
Phase 1 Metabolism - CORRECT ANSWER· Cytochrome P450 system
· Located within the endoplasmic reticulum of hepatocytes.
· Through electron transport chain, a drug bound to the CYP450 system undergoes oxidation or
reduction.
· Drug metabolism in the liver is also affected by:
-Enzyme induction
- Drug interactions
CYP450 - CORRECT ANSWER· CYP: a set of isozymes primarily found in the liver and GI tract
· Convert lipophilic drugs into more polar (and soluble) molecules
· Considerable genetic variability exists across race and gender
· Results in CYP450 polymorphisms which have a direct effect on drug metabolism.
, Four isozymes are responsible for the majority of Phase I Metabolism reactions - CORRECT
ANSWER1. CYP3A4/5
2. CYP2D6
3. CYP2C8/9
4. CYP1A2
If you have a patient experiencing a pharmacokinetic drug interaction, consider...... - CORRECT
ANSWERCYP450.
· Some drugs or exogenous substances can induce CYP isozymes (less effect). Example.... -
CORRECT ANSWERSt. John's wort (CYP3A4) and hormonal birth control
CYP450-related drug interactions can make predicting blood plasma levels/steady state levels
difficult.
Example.... - CORRECT ANSWERIf a drug inhibits enzymatic activity, a substrate drug for that
enzyme system will have a greater concentration in the blood.
If a drug inhibits CYP isozymes, what is the effect of the substrate drug - CORRECT ANSWERThe
substrate drug will have greater effect
Phase 2 Metabolism - CORRECT ANSWER· Polar group is conjugated to the drug
· Results in increased polarity of the drug
Types of phase 2 metabolism reactions - CORRECT ANSWER- Glycine conjugation
-Glucuronide conjugation
-Sulfate conjugation
Midterm With Practice Exam Questions
And Correct Detailed Answers | 100%
Guaranteed Pass | 2026 Newest |
Already Graded A+ | Brand New
Version!!!!!!!!!!
Pharmacology - CORRECT ANSWERthe study of drugs and their structure, targets of action,
mechanisms of action (MOA), distribution (how the body disburses them throughout the body),
desired physiologic effects (efficacy) and undesirable side effects (toxicity).
Pharmacokinetics includes the following: - CORRECT ANSWERADME (absorption, distribution,
metabolism and elimination).
Pharmacokinetics is... - CORRECT ANSWERHow the body effects the drug
Absorption - CORRECT ANSWERabsorption from the administration site either directly or
indirectly into the blood/plasma.
Distribution - CORRECT ANSWERreversibly/irreversibly movement of drug from the
bloodstream into the interstitial and intracellular fluid.
,Metabolism - CORRECT ANSWERdrug biotransformation via metabolic pathways, primarily the
liver, or by other tissues.
Elimination - CORRECT ANSWERhow parent drug & its metabolites are eliminated from the
body
Absorption factors - CORRECT ANSWER· Gastrointestinal pH changes
· Gastric emptying
· Gastric/intestinal enzymes
· Bile acids & biliary function
· Gastrointestinal flora (type and quantity of bacteria)
· Food & nutrient interactions (most common interaction influencing GI drug absorption)
· Lipid solubility of the drug
Distribution factors - CORRECT ANSWER· Membrane permeability: Cross membranes to site of
action
· Blood brain barrier reduces the speed of drug passage into and out of brain tissue
· Plasma protein binding: drugs bound to plasma proteins do not cross membranes (Note:
Malnutrition = âalbumin = á free drug = greater pharmacologic response)
· Aging cause a reduction in production of plasma proteins
· Lipophilicity of drug: lipophilic drugs concentrate in adipose tissue; remain in the body for a
longer period of time
Volume of distribution - CORRECT ANSWER· Body Composition
- Increased Total body water and extracellular fluid
-Decreased Adipose tissue and skeletal muscle
· Protein Binding (changes with aging)
,-Albumin, bilirubin, a1-acid glycoprotein
-Albumin affected by nutrition
-Low albumin (hypoalbuminemia) can cause less protein-bound drug reaching the tissue site of
action.
· Tissue Binding
- Compositional changes
Metabolism factors - CORRECT ANSWERo Drugs can undergo metabolism in the lungs, blood,
liver, intestines and kidney
o Volatile drugs are primarily excreted by the lungs
· The body changes drugs to more or less active forms (metabolites), increases water solubility
to increase elimination.
Phase 1 Metabolism - CORRECT ANSWER· Cytochrome P450 system
· Located within the endoplasmic reticulum of hepatocytes.
· Through electron transport chain, a drug bound to the CYP450 system undergoes oxidation or
reduction.
· Drug metabolism in the liver is also affected by:
-Enzyme induction
- Drug interactions
CYP450 - CORRECT ANSWER· CYP: a set of isozymes primarily found in the liver and GI tract
· Convert lipophilic drugs into more polar (and soluble) molecules
· Considerable genetic variability exists across race and gender
· Results in CYP450 polymorphisms which have a direct effect on drug metabolism.
, Four isozymes are responsible for the majority of Phase I Metabolism reactions - CORRECT
ANSWER1. CYP3A4/5
2. CYP2D6
3. CYP2C8/9
4. CYP1A2
If you have a patient experiencing a pharmacokinetic drug interaction, consider...... - CORRECT
ANSWERCYP450.
· Some drugs or exogenous substances can induce CYP isozymes (less effect). Example.... -
CORRECT ANSWERSt. John's wort (CYP3A4) and hormonal birth control
CYP450-related drug interactions can make predicting blood plasma levels/steady state levels
difficult.
Example.... - CORRECT ANSWERIf a drug inhibits enzymatic activity, a substrate drug for that
enzyme system will have a greater concentration in the blood.
If a drug inhibits CYP isozymes, what is the effect of the substrate drug - CORRECT ANSWERThe
substrate drug will have greater effect
Phase 2 Metabolism - CORRECT ANSWER· Polar group is conjugated to the drug
· Results in increased polarity of the drug
Types of phase 2 metabolism reactions - CORRECT ANSWER- Glycine conjugation
-Glucuronide conjugation
-Sulfate conjugation
