MODULES 1-3 (GALEN)
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This Exam contains: NUR 210 Exam 1 Modules 1-3
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,Question 1
Pharmacokinetics
Correct Answer
The process in which medications move through the body
Rationale:
Pharmacokinetics involves the study of how medications are absorbed, distributed, metabolized, and eliminated by the body, which are
the key processes that govern their movement through the body. This field of study focuses on understanding the time course of drug
concentrations in the body, making the given statement a concise and accurate description of pharmacokinetics.
Question 2
What are the 4 phases of pharmacokinetics?
Correct Answer
absorption, distribution, metabolism, excretion
Rationale:
The concept of "absorption, distribution, metabolism, excretion" describes the four distinct processes that occur in the body over time
as a drug is introduced, processed, and eliminated. This sequence accurately represents the chronological order in which these
processes occur, making it the correct answer to the question about the phases of pharmacokinetics.
Question 3
Absorption
Correct Answer
happens with drug movement from the GI tract into the bloodstream. Most meds are taken by mouth.
Rationale:
Absorption refers to the process by which a substance, such as a medication, is taken into the bloodstream from a specific location,
like the gastrointestinal (GI) tract. The correct statement highlights that the GI tract is a common entry point for orally administered
medications, making it a relevant context for understanding drug absorption.
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,Question 4
Oral absorption
Correct Answer
Takes awhile to get absorbed because it has to go through the GI system
Usually takes 2-4 hours
•Enteric coated
aspirin - hard on stomach
can not crush pill
•Extended release
absorbed in the small intestine
Rationale:
The correct answer highlights the key factors that influence oral absorption, specifically the time it takes for a substance to be
absorbed and the protective measures taken to minimize stomach irritation. The mention of enteric coating and extended release
formulations demonstrates an understanding of the strategies used to control the rate and site of absorption in the gastrointestinal
system.
Question 5
IM absorption
Correct Answer
Absorbed 1-2 hours
Rationale:
The correct answer is based on the typical time frame required for the body to absorb a standard dose of a medication, usually
between 1-2 hours, as this period allows the medication to be fully absorbed through the intestinal mucosa into the bloodstream. This
timeframe applies to most medications, including those taken orally, unless otherwise specified by the medication's pharmacokinetics.
Question 6
IV absorption
Correct Answer
Absorbed 30-60 minutes
Rationale:
The correct answer "Absorbed 30-60 minutes" for IV absorption is due to the large surface area and high flow rate of IV
administration, which allows the solution to be distributed rapidly throughout the bloodstream within 30-60 minutes. This rapid
distribution enables the IV solution to be absorbed quickly, making it an efficient method for delivering medications directly into the
bloodstream.
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, Question 7
dissolution
Correct Answer
Dissolution happens when a po medication breaks down into particles, disintegrates, and dissolves to combine with
liquid so absorption from the GI tract into the bloodstream occurs.
Liquid medications are absorbed faster than solids. Food can interfere with the absorption of drugs.
Rationale:
The correct answer is accurate because dissolution refers to the process of a solid drug breaking down into smaller particles,
disintegrating, and dissolving in a liquid, allowing for efficient absorption into the bloodstream. This process is indeed faster for liquid
medications, and food can interfere with drug absorption by either slowing down the breakdown process or altering the pH levels in
the GI tract, affecting the drug's solubility.
Question 8
Drugs that resist dissolution
Correct Answer
Parenteral medications (SL, eyedrops, inhalants, transdermal) do not pass through the GI tract.
Enteric coated medications are designed to resist disintegration until the pill reaches the small intestine. EC and
sustained release meds should not be crushed.
Rationale:
Parenteral medications bypass the GI tract, preventing them from interacting with stomach acid and digestive enzymes that can break
down or alter the drug, thereby allowing them to resist dissolution. Enteric-coated medications and sustained-release formulations are
designed to target specific sections of the GI tract, where the protective coatings or specific release mechanisms can shield the
medication from digestive processes until it reaches a suitable environment for absorption.
Question 9
Factors that affect absorption
Correct Answer
•Lack of muscle and increased fat changes medicine absorption
•Food consumption - will change medicine potency (delayed)
•Stress - Exercise, medicine goes to muscle
•pH - Medicine is made for acidic environments
•Antacid changes absorption
•Taken alone so it doesn't change the action
Rationale:
These factors affect absorption by influencing the body's physiological environment, which in turn impacts the way medications are
processed and utilized by the body's tissues, including the presence of muscle and fat, the timing of food consumption, and the body's
acidity levels. By altering these conditions, various external factors such as stress, exercise, and antacid use can either enhance or
impede the optimal functioning of medications, ultimately affecting their efficacy and potency.
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