ONS Chemotherapy Biotherapy Certification Exam
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Common nitrosoureas agents: - Answer-Carmustine
(BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - Answer-
Carboplatin
These agents are typically categorized as highly
emetogenic: - Answer-1. Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and
nitrosoureas: - Answer-BUN
Creatinine
CBC w/ diff
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What is the medication Mesna used for? - Answer-Bladder
protectant with administration of cyclophosphamide or
ifosfamide
Instruct pts receiving ________ to avoid exposure to cold
air and consuming cold fluids for 3-4 days following
treatment - Answer-Oxaliplatin
How do antimetabolites function? - Answer-By blocking
DNA and RNA growth by interfering with enzymes needed
for normal cell metabolism
Antimetabolites work in the ___ phase. - Answer-S
Common side effects of antimetabolites: - Answer-
Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Common antimetabolite drugs: - Answer-Azacitidine
Capecitabine
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5-FU
Cytarabine
Decitabine
Methotrexate
The institute for Safe Medication Practices recommends
what route of administration for vincristine? - Answer-IV
piggyback via gravity
Define neoadjuvant therapy - Answer-Treatment is given
prior to surgery to shrink the tumor
Define adjuvant therapy - Answer-Additional cancer
treatment given after the primary treatment to lower the
risk that the cancer reoccur
3 subcategories of alkylating agents: - Answer-1. Nitrogen
mustards
2. Platinum-based agents (do not possess an alkyl group
but still termed alkylating agents as they work similarly)
3. Nitrosoureas
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Common alkylating agents: - Answer-Cyclophosphamide
(Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - Answer-Cisplatin
(Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - Answer-Able
to cross the blood-brain barrier; can be effective in treating
some brain tumors
Anthracycline antitumor abx work by: - Answer-Interfering
with enzymes necessary for DNA to replicate in ALL
phases of the cell cycle
The two major classifications of antitumor antibiotics are: -
Answer-Anthracyclines
Non-anthracyclines